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PDB: 17 件
5DSY
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BU of 5dsy by Molmil
Crystal structure of constitutively active PARP-2
分子名称: 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide, Poly [ADP-ribose] polymerase 2
著者Riccio, A.A, Pascal, J.M.
登録日2015-09-17
公開日2016-07-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain.
Mol.Cell, 60, 2015
5D5K
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BU of 5d5k by Molmil
Crystal Structure NLS from human PARP-2 complexed with Importin alpha delta IBB
分子名称: Importin subunit alpha-1, Poly [ADP-ribose] polymerase 2
著者Riccio, A.A, Cingolani, G, Pascal, J.M.
登録日2015-08-10
公開日2016-06-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage.
Nucleic Acids Res., 44, 2016
7T8C
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Heptameric Human Twinkle Helicase Clinical Variant W315L
分子名称: Twinkle mtDNA helicase
著者Riccio, A.A, Bouvette, J, Krahn, J, Borgnia, M.J, Copeland, W.C.
登録日2021-12-16
公開日2022-07-27
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Structural insight and characterization of human Twinkle helicase in mitochondrial disease.
Proc.Natl.Acad.Sci.USA, 119, 2022
7T8B
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Octameric Human Twinkle Helicase Clinical Variant W315L
分子名称: Twinkle mtDNA helicase
著者Riccio, A.A, Bouvette, J, Krahn, J, Borgnia, M.J, Copeland, W.C.
登録日2021-12-16
公開日2022-07-27
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural insight and characterization of human Twinkle helicase in mitochondrial disease.
Proc.Natl.Acad.Sci.USA, 119, 2022
8UZT
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BU of 8uzt by Molmil
Mitochondrial single-stranded binding protein bound to DNA
分子名称: GLYCEROL, SODIUM ION, Single-stranded DNA-binding protein, ...
著者Riccio, A.A, Pedersen, L.C, Bouvette, J, Borgnia, J.M, Copeland, W.C.
登録日2023-11-16
公開日2024-08-21
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structures of the mitochondrial single-stranded DNA binding protein with DNA and DNA polymerase gamma.
Nucleic Acids Res., 2024
8V5D
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BU of 8v5d by Molmil
Human mitochondrial DNA polymerase catalytic subunit, PolG, in an APO conformation
分子名称: DNA polymerase subunit gamma-1
著者Riccio, A.A, Brannon, A.J, Krahn, J.M, Bouvette, J, Borgnia, J.M, Copeland, W.C.
登録日2023-11-30
公開日2024-07-10
最終更新日2024-07-31
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Coordinated DNA polymerization by Pol gamma and the region of LonP1 regulated proteolysis.
Nucleic Acids Res., 52, 2024
8V55
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Human mitochondrial DNA polymerase gamma bound to a replication fork in an open conformation
分子名称: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ...
著者Riccio, A.A, Krahn, J.M, Bouvette, J, Borgnia, M.J, Copeland, W.C.
登録日2023-11-30
公開日2024-07-10
最終更新日2024-07-31
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Coordinated DNA polymerization by Pol gamma and the region of LonP1 regulated proteolysis.
Nucleic Acids Res., 52, 2024
8V54
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Engaged conformation of the human mitochondrial DNA polymerase gamma bound to DNA
分子名称: DNA (25-MER), DNA (44-MER), DNA polymerase subunit gamma-1, ...
著者Riccio, A.A, Krahn, J.M, Bouvette, J, Borgnia, J.M, Copeland, W.C.
登録日2023-11-30
公開日2024-07-10
最終更新日2024-07-31
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Coordinated DNA polymerization by Pol gamma and the region of LonP1 regulated proteolysis.
Nucleic Acids Res., 52, 2024
8V5R
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BU of 8v5r by Molmil
Active conformation of DNA polymerase gamma bound to DNA
分子名称: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, ...
著者Riccio, A.A, Krahn, J.M, Bouvette, J, Borgnia, J.M, Copeland, W.C.
登録日2023-11-30
公開日2024-07-10
最終更新日2024-07-31
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Coordinated DNA polymerization by Pol gamma and the region of LonP1 regulated proteolysis.
Nucleic Acids Res., 52, 2024
5KNI
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BU of 5kni by Molmil
Crystal Structure of the wild-type SAM domain of human Tankyrase-1
分子名称: Tankyrase-1
著者Pascal, J.M, McCauley, M, Langelier, M.F, Riccio, A.A.
登録日2016-06-28
公開日2016-08-31
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Tankyrase Sterile alpha Motif Domain Polymerization Is Required for Its Role in Wnt Signaling.
Structure, 24, 2016
6P0B
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BU of 6p0b by Molmil
Human DNA Ligase 1 (E346A/E592A) Bound to an Adenylated, dideoxy Terminated DNA nick with 200 mM Mg2+
分子名称: ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ...
著者Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A.
登録日2019-05-16
公開日2019-12-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.203 Å)
主引用文献Two-tiered enforcement of high-fidelity DNA ligation.
Nat Commun, 10, 2019
6P0A
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BU of 6p0a by Molmil
Human DNA Ligase 1 Bound to an Adenylated, dideoxy Terminated DNA nick with 2 mM Mg2+
分子名称: ADENOSINE MONOPHOSPHATE, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), DNA (5'-D(*GP*TP*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
著者Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A.
登録日2019-05-16
公開日2019-12-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Two-tiered enforcement of high-fidelity DNA ligation.
Nat Commun, 10, 2019
6P0D
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BU of 6p0d by Molmil
Human DNA Ligase 1 (E346A/E592A) Bound to an Adenylated, hydroxyl terminated DNA nick
分子名称: ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ...
著者Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A.
登録日2019-05-16
公開日2019-12-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Two-tiered enforcement of high-fidelity DNA ligation.
Nat Commun, 10, 2019
6P0C
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BU of 6p0c by Molmil
Human DNA Ligase 1 Bound to an Adenylated, hydroxyl terminated DNA nick in EDTA
分子名称: ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ...
著者Schellenberg, M.J, Tumbale, P.S, Riccio, A.A, Williams, R.S.
登録日2019-05-16
公開日2019-12-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Two-tiered enforcement of high-fidelity DNA ligation.
Nat Commun, 10, 2019
6P09
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BU of 6p09 by Molmil
Human DNA Ligase 1 Bound to an Adenylated, dideoxy Terminated DNA nick with 200 mM Mg2+
分子名称: ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ...
著者Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A.
登録日2019-05-16
公開日2019-12-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.052 Å)
主引用文献Two-tiered enforcement of high-fidelity DNA ligation.
Nat Commun, 10, 2019
6P0E
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BU of 6p0e by Molmil
Human DNA Ligase 1 (E346A,E592A) bound to adenylated DNA containing an 8-oxo guanine:adenine base-pair
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, ...
著者Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A.
登録日2019-05-16
公開日2019-12-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Two-tiered enforcement of high-fidelity DNA ligation.
Nat Commun, 10, 2019
6Q1V
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BU of 6q1v by Molmil
Human DNA Ligase 1 (E592R) Bound to an Adenylated, hydroxyl terminated DNA nick
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ADENOSINE MONOPHOSPHATE, ...
著者Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A.
登録日2019-08-06
公開日2019-12-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Two-tiered enforcement of high-fidelity DNA ligation.
Nat Commun, 10, 2019

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件を2024-09-04に公開中

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