4IAL
 
 | | Crystal structure of Staphylococcal nuclease variant Delta+PHS H121E at cryogenic temperature | | Descriptor: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | | Authors: | Bell-Upp, P.C, Schlessman, J.L, Heroux, A, Garcia-Moreno E, B. | | Deposit date: | 2012-12-06 | | Release date: | 2013-01-09 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.595 Å) | | Cite: | Crystal structure of Staphylococcal nuclease variant Delta+PHS H121E at cryogenic temperature
To be Published
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4CSI
 | | Crystal structure of the thermostable Cellobiohydrolase Cel7A from the fungus Humicola grisea var. thermoidea. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CELLULASE, DI(HYDROXYETHYL)ETHER | | Authors: | Haddad-Momeni, M, Goedegebuur, F, Hansson, H, Karkehabadi, S, Askarieh, G, Mitchinson, C, Larenas, E, Stahlberg, J, Sandgren, M. | | Deposit date: | 2014-03-07 | | Release date: | 2014-09-10 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Expression, Crystal Structure and Cellulase Activity of the Thermostable Cellobiohydrolase Cel7A from the Fungus Humicola Grisea Var. Thermoidea.
Acta Crystallogr.,Sect.D, 70, 2014
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5FMT
 | | CrIFT54 CH-domain | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, FLAGELLAR ASSOCIATED PROTEIN, GLYCEROL, ... | | Authors: | Weber, K, Lorentzen, E. | | Deposit date: | 2015-11-09 | | Release date: | 2016-03-09 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.878 Å) | | Cite: | Intraflagellar Transport Proteins 172, 80, 57, 54, 38, and 20 Form a Stable Tubulin-Binding Ift-B2 Complex.
Embo J., 35, 2016
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5FMU
 | | MmIFT54 CH-domain | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, TRAF3-INTERACTING PROTEIN 1 | | Authors: | Weber, K, Lorentzen, E. | | Deposit date: | 2015-11-09 | | Release date: | 2016-03-09 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.593 Å) | | Cite: | Intraflagellar Transport Proteins 172, 80, 57, 54, 38, and 20 Form a Stable Tubulin-Binding Ift-B2 Complex.
Embo J., 35, 2016
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5FMR
 | | crIFT52 N-terminal domain | | Descriptor: | INTRAFLAGELLAR TRANSPORT PROTEIN COMPONENT IFT52, SULFATE ION | | Authors: | Mourao, A, Vetter, M, Lorentzen, E. | | Deposit date: | 2015-11-09 | | Release date: | 2016-03-09 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Intraflagellar Transport Proteins 172, 80, 57, 54, 38, and 20 Form a Stable Tubulin-Binding Ift-B2 Complex.
Embo J., 35, 2016
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5FMS
 | | mmIFT52 N-terminal domain | | Descriptor: | INTRAFLAGELLAR TRANSPORT PROTEIN 52 HOMOLOG | | Authors: | Mourao, A, Lorentzen, E. | | Deposit date: | 2015-11-09 | | Release date: | 2016-03-09 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.488 Å) | | Cite: | Intraflagellar Transport Proteins 172, 80, 57, 54, 38, and 20 Form a Stable Tubulin-Binding Ift-B2 Complex.
Embo J., 35, 2016
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6H4G
 | | Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma brucei: E311A, T318R, V319A mutant bound to cAMP in the A site | | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, INOSINE, Protein kinase A regulatory subunit | | Authors: | Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M. | | Deposit date: | 2018-07-21 | | Release date: | 2019-08-14 | | Last modified: | 2024-04-10 | | Method: | X-RAY DIFFRACTION (2.143517 Å) | | Cite: | Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens.
Elife, 12, 2024
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4WZH
 | | Dihydroorotate dehydrogenase from Leishmania Viannia braziliensis | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... | | Authors: | Reis, R.A.G, Lorenzato, E, Silva, V.C, Nonato, M.C. | | Deposit date: | 2014-11-19 | | Release date: | 2015-05-13 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | Recombinant production, crystallization and crystal structure determination of dihydroorotate dehydrogenase from Leishmania (Viannia) braziliensis.
Acta Crystallogr.,Sect.F, 71, 2015
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6HYI
 | | Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi at 1.4 A resolution in complex with inosine | | Descriptor: | INOSINE, Protein kinase A regulatory subunit | | Authors: | Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M. | | Deposit date: | 2018-10-22 | | Release date: | 2019-11-13 | | Last modified: | 2024-04-10 | | Method: | X-RAY DIFFRACTION (1.39944851 Å) | | Cite: | Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens.
Elife, 12, 2024
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6HYQ
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6IAN
 | | T. brucei IFT22/74/81 GTP-bound crystal structure | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Intraflagellar transport protein 74, Intraflagellar transport protein 81, ... | | Authors: | Wachter, S, Basquin, J, Lorentzen, E. | | Deposit date: | 2018-11-27 | | Release date: | 2019-05-01 | | Last modified: | 2019-05-08 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Binding of IFT22 to the intraflagellar transport complex is essential for flagellum assembly.
Embo J., 38, 2019
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6IA7
 | | T. brucei IFT22 GTP-bound crystal structure | | Descriptor: | CALCIUM ION, GUANOSINE-5'-TRIPHOSPHATE, Intraflagellar transport protein 22, ... | | Authors: | Wachter, S, Basquin, J, Lorentzen, E. | | Deposit date: | 2018-11-26 | | Release date: | 2019-04-10 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Binding of IFT22 to the intraflagellar transport complex is essential for flagellum assembly.
Embo J., 38, 2019
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6IAE
 | | T. brucei IFT22 GDP-bound crystal structure | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Intraflagellar transport protein 22, MAGNESIUM ION | | Authors: | Wachter, S, Basquin, J, Lorentzen, E. | | Deposit date: | 2018-11-26 | | Release date: | 2019-04-10 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | Binding of IFT22 to the intraflagellar transport complex is essential for flagellum assembly.
Embo J., 38, 2019
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5IFE
 | | Crystal structure of the human SF3b core complex | | Descriptor: | PHD finger-like domain-containing protein 5A, POTASSIUM ION, Splicing factor 3B subunit 1, ... | | Authors: | Cretu, C, Dybkov, O, De Laurentiis, E, Will, C.L, Luhrmann, R, Pena, V. | | Deposit date: | 2016-02-25 | | Release date: | 2016-10-26 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.
Mol.Cell, 64, 2016
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4YNC
 | | OYE1 W116A COMPLEXED WITH (Z)-METHYL-3-CYANO-3-PHENYLACRYLATE IN A NON PRODUCTIVE BINDING MODE | | Descriptor: | CHLORIDE ION, FLAVIN MONONUCLEOTIDE, NADPH dehydrogenase 1, ... | | Authors: | Santangelo, S, Brenna, E, Stewart, J.D, Powell III, R.W. | | Deposit date: | 2015-03-09 | | Release date: | 2016-01-20 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.498 Å) | | Cite: | Opposite Enantioselectivity in the Bioreduction of (Z)-beta-Aryl-beta-cyanoacrylates Mediated by the Tryptophan 116 Mutants of Old Yellow Enzyme 1: Synthetic Approach to (R)- and (S)-beta-Aryl-gamma-lactams
Adv.Synth.Catal., 357, 2015
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4YIL
 | | OYE1 W116A COMPLEXED WITH (Z)-METHYL 3-CYANO-3-(4-FLUOROPHENYL)ACRYLATE IN A NON PRODUCTIVE BINDING MODE | | Descriptor: | FLAVIN MONONUCLEOTIDE, MAGNESIUM ION, NADPH dehydrogenase 1, ... | | Authors: | Santangelo, S, Brenna, E, Stewart, J.D, Powell III, R.W. | | Deposit date: | 2015-03-02 | | Release date: | 2016-01-20 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.461 Å) | | Cite: | Opposite Enantioselectivity in the Bioreduction of (Z)-beta-Aryl-beta-cyanoacrylates Mediated by the Tryptophan 116 Mutants of Old Yellow Enzyme 1: Synthetic Approach to (R)- and (S)-beta-Aryl-gamma-lactams
Adv.Synth.Catal., 357, 2015
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3GKW
 | | Crystal structure of the Fab fragment of Nimotuzumab. An anti-epidermal growth factor receptor antibody | | Descriptor: | DI(HYDROXYETHYL)ETHER, Heavy chain of the antibody Nimotuzumab, Light chain of the antibody Nimotuzumab, ... | | Authors: | Talavera, A, Friemann, R, Martinez-Fleites, C, Moreno, E, Krengel, U. | | Deposit date: | 2009-03-11 | | Release date: | 2009-08-04 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation
Cancer Res., 69, 2009
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4P17
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4FMS
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3TP5
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3RUZ
 | | Crystal structure of Staphylococcal nuclease variant Delta+PHS V74K at cryogenic temperature | | Descriptor: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | | Authors: | Caro, J.A, Clark, I, Heroux, A, Schlessman, J.L, Garcia-Moreno E, B. | | Deposit date: | 2011-05-05 | | Release date: | 2011-06-15 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | Internal ionizable residues in proteins
To be Published
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3S9W
 | | Crystal structure of Staphylococcal nuclease variant Delta+PHS M98G bound to Ca2+ and thymidine-5',3'-diphosphate at cryogenic temperature | | Descriptor: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | | Authors: | Doctrow, B.M, Schlessman, J.L, Garcia-Moreno E, B, Heroux, A. | | Deposit date: | 2011-06-02 | | Release date: | 2011-06-22 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of Staphylococcal nuclease variant Delta+PHS M98G bound to Ca2+ and thymidine-5',3'-diphosphate at cryogenic temperature
To be Published
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3SK8
 | | Crystal structure of Staphylococcal nuclease variant Delta+PHS M98G apo protein at cryogenic temperature | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, PHOSPHATE ION, Thermonuclease | | Authors: | Doctrow, B.M, Schlessman, J.L, Garcia-Moreno E, B, Heroux, A. | | Deposit date: | 2011-06-22 | | Release date: | 2011-07-06 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of Staphylococcal nuclease variant Delta+PHS M98G apo protein at cryogenic temperature
To be Published
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3SXH
 | | Crystal structure of Staphylococcal nuclease variant Delta+PHS I92AL103A at cryogenic temperature | | Descriptor: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | | Authors: | Caro, J.A, Clark, I, Schlessman, J.L, Heroux, A, Garcia-Moreno E, B. | | Deposit date: | 2011-07-14 | | Release date: | 2011-07-27 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Crystal structure of Staphylococcal nuclease variant Delta+PHS I92AL103A at cryogenic temperature
To be Published
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3T16
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