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PDB: 117 results
1VZ2
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BU of 1vz2 by Molmil
PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, Y73C/V427C/C255T MUTANT
Descriptor: GLYCEROL, PROLYL ENDOPEPTIDASE
Authors:Rea, D, Fulop, V.
Deposit date:2004-05-14
Release date:2004-07-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Concerted Structural Changes in the Peptidase and the Propeller Domains of Prolyl Oligopeptidase are Required for Substrate Binding
J.Mol.Biol., 340, 2004
1VZ3
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BU of 1vz3 by Molmil
PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, T597C MUTANT
Descriptor: GLYCEROL, PROLYL ENDOPEPTIDASE
Authors:Rea, D, Fulop, V.
Deposit date:2004-05-14
Release date:2004-07-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Concerted Structural Changes in the Peptidase and the Propeller Domains of Prolyl Oligopeptidase are Required for Substrate Binding
J.Mol.Biol., 340, 2004
2V5J
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BU of 2v5j by Molmil
Apo Class II aldolase HpcH
Descriptor: 2,4-DIHYDROXYHEPT-2-ENE-1,7-DIOIC ACID ALDOLASE, GLYCEROL, PHOSPHATE ION
Authors:Rea, D, Fulop, V, Bugg, T.D.H, Roper, D.I.
Deposit date:2007-07-05
Release date:2007-10-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure and Mechanism of Hpch: A Metal Ion Dependent Class II Aldolase from the Homoprotocatechuate Degradation Pathway of Escherichia Coli.
J.Mol.Biol., 373, 2007
2V5K
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BU of 2v5k by Molmil
Class II aldolase HpcH - magnesium - oxamate complex
Descriptor: 2,4-DIHYDROXYHEPT-2-ENE-1,7-DIOIC ACID ALDOLASE, MAGNESIUM ION, OXAMIC ACID, ...
Authors:Rea, D, Fulop, V, Bugg, T.D.H, Roper, D.I.
Deposit date:2007-07-06
Release date:2007-10-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and Mechanism of Hpch: A Metal Ion Dependent Class II Aldolase from the Homoprotocatechuate Degradation Pathway of Escherichia Coli.
J.Mol.Biol., 373, 2007
2VWT
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BU of 2vwt by Molmil
Crystal structure of YfaU, a metal ion dependent class II aldolase from Escherichia coli K12 - Mg-pyruvate product complex
Descriptor: GLYCEROL, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Rea, D, Rakus, J.F, Gerlt, J.A, Fulop, V, Bugg, T.D.H, Roper, D.I.
Deposit date:2008-06-26
Release date:2008-09-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Crystal Structure and Functional Assignment of Yfau, a Metal Ion Dependent Class II Aldolase from Escherichia Coli K12.
Biochemistry, 47, 2008
2VWS
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Crystal structure of YfaU, a metal ion dependent class II aldolase from Escherichia coli K12
Descriptor: GLYCEROL, PHOSPHATE ION, YFAU, ...
Authors:Rea, D, Rakus, J.F, Gerlt, J.A, Fulop, V, Bugg, T.D.H, Roper, D.I.
Deposit date:2008-06-26
Release date:2008-09-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Crystal Structure and Functional Assignment of Yfau, a Metal Ion Dependent Class II Aldolase from Escherichia Coli K12.
Biochemistry, 47, 2008
1UOP
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BU of 1uop by Molmil
PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, S554A MUTANT WITH BOUND PEPTIDE LIGAND GLY-PHE-GLU-PRO
Descriptor: GLYCEROL, PEPTIDE LIGAND GLY-PHE-GLU-PRO, PROLYL ENDOPEPTIDASE
Authors:Rea, D, Fulop, V.
Deposit date:2003-09-22
Release date:2003-10-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Electrostatic Environment at the Active Site of Prolyl Oligopeptidase is Highly Influential During Substrate Binding
J.Biol.Chem., 278, 2003
1UOQ
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BU of 1uoq by Molmil
PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, S554A MUTANT WITH BOUND PEPTIDE LIGAND GLU-PHE-SER-PRO
Descriptor: GLYCEROL, PEPTIDE LIGAND GLU-PHE-SER-PRO, PROLYL ENDOPEPTIDASE
Authors:Rea, D, Fulop, V.
Deposit date:2003-09-22
Release date:2003-10-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Electrostatic Environment at the Active Site of Prolyl Oligopeptidase is Highly Influential During Substrate Binding
J.Biol.Chem., 278, 2003
1UOO
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Prolyl oligopeptidase from porcine brain, S554A mutant with bound peptide ligand GLY-PHE-ARG-PRO
Descriptor: GLYCEROL, PEPTIDE LIGAND GLY-PHE-ARG-PRO, PROLYL ENDOPEPTIDASE
Authors:Rea, D, Fulop, V.
Deposit date:2003-09-22
Release date:2003-10-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Electrostatic Environment at the Active Site of Prolyl Oligopeptidase is Highly Influential During Substrate Binding
J.Biol.Chem., 278, 2003
1H2Z
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BU of 1h2z by Molmil
PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, S554A MUTANT WITH BOUND PEPTIDE LIGAND SUC-GLY-PRO
Descriptor: GLYCEROL, GLYCINE, PROLINE, ...
Authors:Rea, D, Fulop, V.
Deposit date:2002-08-20
Release date:2002-11-11
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Electrostatic Effects and Binding Determinants in the Catalysis of Prolyl Oligopeptidase: Site Specific Mutagenesis at the Oxyanion Binding Site
J.Biol.Chem., 277, 2002
1H2Y
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BU of 1h2y by Molmil
PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, Y473F MUTANT WITH COVALENTLY BOUND INHIBITOR Z-PRO-PROLINAL
Descriptor: GLYCEROL, N-BENZYLOXYCARBONYL-L-PROLYL-L-PROLINAL, PROLYL ENDOPEPTIDASE
Authors:Rea, D, Fulop, V.
Deposit date:2002-08-20
Release date:2002-11-11
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Electrostatic Effects and Binding Determinants in the Catalysis of Prolyl Oligopeptidase: Site Specific Mutagenesis at the Oxyanion Binding Site
J.Biol.Chem., 277, 2002
1O6G
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BU of 1o6g by Molmil
PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, D641N MUTANT WITH BOUND PEPTIDE LIGAND SUC-GLY-PRO
Descriptor: GLYCINE, PROLINE, Prolyl endopeptidase, ...
Authors:Rea, D, Fulop, V.
Deposit date:2002-09-15
Release date:2002-11-18
Last modified:2024-08-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Substrate-dependent competency of the catalytic triad of prolyl oligopeptidase.
J. Biol. Chem., 277, 2002
1O6F
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BU of 1o6f by Molmil
PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, D641A MUTANT WITH BOUND PEPTIDE LIGAND SUC-GLY-PRO
Descriptor: GLYCEROL, GLYCINE, PROLINE, ...
Authors:Rea, D, Fulop, V.
Deposit date:2002-09-15
Release date:2002-11-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Substrate-dependent competency of the catalytic triad of prolyl oligopeptidase.
J. Biol. Chem., 277, 2002
6EHV
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BU of 6ehv by Molmil
scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery
Descriptor: scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery
Authors:Hargreaves, D.
Deposit date:2017-09-15
Release date:2017-11-08
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery
To Be Published
6EHW
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BU of 6ehw by Molmil
scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery
Descriptor: scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery
Authors:Hargreaves, D.
Deposit date:2017-09-15
Release date:2017-11-08
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery
To Be Published
6EHX
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BU of 6ehx by Molmil
scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery
Descriptor: scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery
Authors:Hargreaves, D.
Deposit date:2017-09-15
Release date:2017-11-08
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery
To Be Published
1M1F
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BU of 1m1f by Molmil
Kid toxin protein from E.coli plasmid R1
Descriptor: Kid toxin protein, PHOSPHATE ION
Authors:Hargreaves, D, Santos-Sierra, S, Giraldo, R, Sabariegos-Jareno, R, de la Cueva-Mendez, G, Boelens, R, Diaz-Orejas, R, Rafferty, J.B.
Deposit date:2002-06-19
Release date:2002-11-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural and Functional Analysis of the Kid toxin protein from E.coli plasmid R1
Structure, 10, 2002
6EHY
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BU of 6ehy by Molmil
scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery
Descriptor: scFv antibody fragment
Authors:Hargreaves, D.
Deposit date:2017-09-15
Release date:2017-11-08
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery
To Be Published
2A41
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BU of 2a41 by Molmil
Ternary complex of the WH2 Domain of WIP with Actin-DNAse I
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ...
Authors:Chereau, D, Kerff, F, Dominguez, R.
Deposit date:2005-06-27
Release date:2005-11-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly
Proc.Natl.Acad.Sci.Usa, 102, 2005
2A42
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BU of 2a42 by Molmil
Actin-DNAse I Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Actin, ...
Authors:Chereau, D, Kerff, F, Dominguez, R.
Deposit date:2005-06-27
Release date:2005-11-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly
Proc.Natl.Acad.Sci.Usa, 102, 2005
4N8M
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BU of 4n8m by Molmil
Structural polymorphism in the N-terminal oligomerization domain of NPM1
Descriptor: COBALT (II) ION, Nucleophosmin
Authors:Mitrea, D, Royappa, G, Buljan, M, Yun, M, Pytel, N, Satumba, J, Nourse, A, Park, C, Babu, M.M, White, S.W, Kriwacki, R.W.
Deposit date:2013-10-17
Release date:2014-03-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Structural polymorphism in the N-terminal oligomerization domain of NPM1.
Proc.Natl.Acad.Sci.USA, 111, 2014
1BDX
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BU of 1bdx by Molmil
E. COLI DNA HELICASE RUVA WITH BOUND DNA HOLLIDAY JUNCTION, ALPHA CARBONS AND PHOSPHATE ATOMS ONLY
Descriptor: DNA (5'-D(P*GP*CP*AP*TP*GP*CP*AP*TP*AP*TP*GP*CP*AP*TP*GP*C)-3'), HOLLIDAY JUNCTION DNA HELICASE RUVA
Authors:Hargreaves, D, Rice, D.W, Sedelnikova, S.E, Artymiuk, P.J, Lloyd, R.G, Rafferty, J.B.
Deposit date:1998-05-11
Release date:1999-11-24
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (6 Å)
Cite:Crystal structure of E.coli RuvA with bound DNA Holliday junction at 6 A resolution.
Nat.Struct.Biol., 5, 1998
2A3Z
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BU of 2a3z by Molmil
Ternary complex of the WH2 domain of WASP with Actin-DNAse I
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Actin, ...
Authors:Chereau, D, Kerff, F, Dominguez, R.
Deposit date:2005-06-27
Release date:2005-11-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.078 Å)
Cite:Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly
Proc.Natl.Acad.Sci.Usa, 102, 2005
2A40
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BU of 2a40 by Molmil
Ternary complex of the WH2 domain of WAVE with Actin-DNAse I
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Actin, ...
Authors:Chereau, D, Kerff, F, Dominguez, R.
Deposit date:2005-06-27
Release date:2005-11-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly
Proc.Natl.Acad.Sci.Usa, 102, 2005
8PO0
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BU of 8po0 by Molmil
Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 12 bound to EGFRinsNPG
Descriptor: 1-[3-[7-methoxy-4-[3-(3-methoxyphenyl)-1~{H}-pyrazol-4-yl]quinazolin-6-yl]oxyazetidin-1-yl]propan-1-one, Epidermal growth factor receptor
Authors:Hargreaves, D.
Deposit date:2023-07-03
Release date:2024-06-05
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.523 Å)
Cite:Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations.
J.Med.Chem., 67, 2024

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