6X3V
 
 | | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus etomidate | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Etomidate, ... | | Authors: | Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E. | | Deposit date: | 2020-05-21 | | Release date: | 2020-09-09 | | Last modified: | 2024-01-31 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Shared structural mechanisms of general anaesthetics and benzodiazepines.
Nature, 585, 2020
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2P2N
 | | Crystal Structure and Allosteric Regulation of the Cytoplasmic Escherichia coli L-Asparaginase I | | Descriptor: | 1,2-ETHANEDIOL, ASPARAGINE, ASPARTIC ACID, ... | | Authors: | Yun, M.-K, Nourse, A, White, S.W, Rock, C.O, Heath, R.J. | | Deposit date: | 2007-03-07 | | Release date: | 2007-05-15 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal Structure and Allosteric Regulation of the Cytoplasmic Escherichia colil-Asparaginase I
J.Mol.Biol., 369, 2007
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5WBN
 | | Crystal structure of fragment 3-(3-Benzyl-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain | | Descriptor: | 3-(3-benzyl-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)propanoic acid, ACETATE ION, CHLORIDE ION, ... | | Authors: | Harding, R.J, Walker, J.R, Ferreira de Freitas, R, Ravichandran, M, Santhakumar, V, Schapira, M, Bountra, C, Edwards, A.M, Arrowsmith, C.H. | | Deposit date: | 2017-06-29 | | Release date: | 2017-08-02 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Crystal structure of fragment 3-(3-Benzyl-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain
To be published
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2PKL
 | | Androgen receptor LBD with small molecule | | Descriptor: | 5-ALPHA-DIHYDROTESTOSTERONE, ARA70 peptide, Androgen receptor, ... | | Authors: | Estebanez-Perpina, E, Arnold, A.A, Baxter, J.D, Guy, K.R, Webb, P, Fletterick, R.J. | | Deposit date: | 2007-04-17 | | Release date: | 2007-09-25 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | A surface on the androgen receptor that allosterically regulates coactivator binding.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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5WWS
 | | Crystal structure of human NSun6/tRNA/SAM | | Descriptor: | Putative methyltransferase NSUN6, S-ADENOSYLMETHIONINE, tRNA | | Authors: | Liu, R.J, Long, T, Wang, E.D. | | Deposit date: | 2017-01-04 | | Release date: | 2017-06-28 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.247 Å) | | Cite: | Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6
Nucleic Acids Res., 45, 2017
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2Q5T
 | | Full-length Cholix toxin from Vibrio Cholerae | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Cholix toxin | | Authors: | Jorgensen, R, Fieldhouse, R.J, Merrill, A.R. | | Deposit date: | 2007-06-01 | | Release date: | 2008-02-12 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Cholix Toxin, a Novel ADP-ribosylating Factor from Vibrio cholerae.
J.Biol.Chem., 283, 2008
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2OM2
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2OVC
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2P5V
 | | Crystal Structure of Transcriptional Regulator NMB0573 from Neisseria Meningitidis | | Descriptor: | CALCIUM ION, CHLORIDE ION, GLYCEROL, ... | | Authors: | Ren, J, Sainsbury, S, Owens, R.J, Oxford Protein Production Facility (OPPF) | | Deposit date: | 2007-03-16 | | Release date: | 2007-04-03 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | The Structure and Transcriptional Analysis of a Global Regulator from Neisseria meningitidis.
J.Biol.Chem., 282, 2007
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2P6S
 | | Crystal Structure of Transcriptional Regulator NMB0573/L-Met Complex from Neisseria Meningitidis | | Descriptor: | CALCIUM ION, GLYCEROL, METHIONINE, ... | | Authors: | Ren, J, Sainsbury, S, Owens, R.J, Oxford Protein Production Facility (OPPF) | | Deposit date: | 2007-03-19 | | Release date: | 2007-04-03 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The Structure and Transcriptional Analysis of a Global Regulator from Neisseria meningitidis.
J.Biol.Chem., 282, 2007
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2OUL
 | | The Structure of Chagasin in Complex with a Cysteine Protease Clarifies the Binding Mode and Evolution of a New Inhibitor Family | | Descriptor: | Chagasin, Falcipain 2 | | Authors: | Wang, S.X, Chand, K, Huang, R, Whisstock, J, Jacobelli, J, Fletterick, R.J, Rosenthal, P.J, McKerrow, J.H. | | Deposit date: | 2007-02-11 | | Release date: | 2008-02-26 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family.
Structure, 15, 2007
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2P2D
 | | Crystal Structure and Allosteric Regulation of the Cytoplasmic Escherichia coli L-Asparaginase I | | Descriptor: | GLYCEROL, L-ASPARAGINASE I | | Authors: | Yun, M.-K, Nourse, A, White, S.W, Rock, C.O, Heath, R.J. | | Deposit date: | 2007-03-07 | | Release date: | 2007-05-15 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Crystal Structure and Allosteric Regulation of the Cytoplasmic Escherichia colil-Asparaginase I
J.Mol.Biol., 369, 2007
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2NAZ
 | | The solution NMR structure of the C-terminal effector domain of BfmR from Acinetobacter baumannii | | Descriptor: | Transcriptional regulatory protein RstA | | Authors: | Olson, A.L, Thompson, R.J, Cavanagh, J, Feldmann, E.A, Bobay, B.G. | | Deposit date: | 2016-01-15 | | Release date: | 2017-01-18 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | The Structure of the Biofilm-controlling Response Regulator BfmR from Acinetobacter baumannii Reveals Details of Its DNA-binding Mechanism.
J.Mol.Biol., 430, 2018
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2NPU
 | | The solution structure of the rapamycin-binding domain of mTOR (FRB) | | Descriptor: | FKBP12-rapamycin complex-associated protein | | Authors: | Veverka, V, Crabbe, T, Bird, I, Lennie, G, Muskett, F.W, Taylor, R.J, Carr, M.D. | | Deposit date: | 2006-10-30 | | Release date: | 2007-09-18 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR.
Oncogene, 27, 2008
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2MSQ
 | | Solution study of cBru9a | | Descriptor: | Conotoxin cBru9a | | Authors: | Akcan, M, Clark, R.J, Daly, N.L, Conibear, A.C, de Faoite, A.C, Heghinian, M.C, Adams, D.J, Mari, F, Craik, D.J. | | Deposit date: | 2014-08-05 | | Release date: | 2015-07-22 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins.
Biopolymers, 104, 2015
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2NS6
 | | Crystal Structure of the Minimal Relaxase Domain of MobA from Plasmid R1162 | | Descriptor: | MANGANESE (II) ION, Mobilization protein A | | Authors: | Monzingo, A.F, Ozburn, A, Xia, S, Meyer, R.J, Robertus, J.D. | | Deposit date: | 2006-11-03 | | Release date: | 2007-02-06 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The Structure of the Minimal Relaxase Domain of MobA at 2.1 A Resolution.
J.Mol.Biol., 366, 2007
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2NVK
 | | Crystal Structure of Thioredoxin Reductase from Drosophila melanogaster | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Thioredoxin Reductase | | Authors: | Eckenroth, B.E, Rould, M.A, Hondal, R.J, Everse, S.J. | | Deposit date: | 2006-11-13 | | Release date: | 2007-04-24 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural and Biochemical Studies Reveal Differences in the Catalytic Mechanisms of Mammalian and Drosophila melanogaster Thioredoxin Reductases.
Biochemistry, 46, 2007
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2NVW
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2O59
 | | Structure of E. coli topoisomerase III in complex with an 8-base single stranded oligonucleotide. Frozen in glycerol pH 8.0 | | Descriptor: | 5'-D(*CP*GP*CP*AP*AP*CP*TP*T)-3', ACETIC ACID, CHLORIDE ION, ... | | Authors: | Changela, A, DiGate, R.J, Mondragon, A. | | Deposit date: | 2006-12-05 | | Release date: | 2007-04-03 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural Studies of E. coli Topoisomerase III-DNA Complexes Reveal a Novel Type IA Topoisomerase-DNA Conformational Intermediate.
J.Mol.Biol., 368, 2007
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2QFG
 | | Solution Structure of the N-terminal SCR-1/5 fragment of Complement Factor H. | | Descriptor: | Complement factor H | | Authors: | Okemefuna, A.I, Gilbert, H.E, Griggs, K.M, Ormsby, R.J, Gordon, D.L, Perkins, S.J. | | Deposit date: | 2007-06-27 | | Release date: | 2007-09-25 | | Last modified: | 2024-02-21 | | Method: | SOLUTION SCATTERING | | Cite: | The regulatory SCR-1/5 and cell surface-binding SCR-16/20 fragments of factor H reveal partially folded-back solution structures and different self-associative properties.
J.Mol.Biol., 375, 2008
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2NC3
 | | Solution Structure of N-Allosylated Pin1 WW Domain | | Descriptor: | Pin1 WW Domain, beta-D-allopyranose | | Authors: | Hsu, C, Park, S, Mortenson, D.E, Foley, B, Wang, X, Woods, R.J, Case, D.A, Powers, E.T, Wong, C, Dyson, H, Kelly, J.W. | | Deposit date: | 2016-03-20 | | Release date: | 2016-06-08 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | The Dependence of Carbohydrate-Aromatic Interaction Strengths on the Structure of the Carbohydrate.
J.Am.Chem.Soc., 138, 2016
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2NC4
 | | Solution Structure of N-Galactosylated Pin1 WW Domain | | Descriptor: | Pin1 WW Domain, beta-D-galactopyranose | | Authors: | Hsu, C, Park, S, Mortenson, D.E, Foley, B, Wang, X, Woods, R.J, Case, D.A, Powers, E.T, Wong, C, Dyson, H, Kelly, J.W. | | Deposit date: | 2016-03-20 | | Release date: | 2016-06-08 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | The Dependence of Carbohydrate-Aromatic Interaction Strengths on the Structure of the Carbohydrate.
J.Am.Chem.Soc., 138, 2016
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2NC5
 | | Solution Structure of N-Xylosylated Pin1 WW Domain | | Descriptor: | Pin1 WW Domain, beta-D-xylopyranose | | Authors: | Hsu, C, Park, S, Mortenson, D.E, Foley, B, Wang, X, Woods, R.J, Case, D.A, Powers, E.T, Wong, C, Dyson, H, Kelly, J.W. | | Deposit date: | 2016-03-20 | | Release date: | 2016-06-08 | | Last modified: | 2020-07-29 | | Method: | SOLUTION NMR | | Cite: | The Dependence of Carbohydrate-Aromatic Interaction Strengths on the Structure of the Carbohydrate.
J.Am.Chem.Soc., 138, 2016
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2NCD
 | | NCD (NON-CLARET DISJUNCTIONAL) DIMER FROM D. MELANOGASTER | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, PROTEIN (Kinesin motor NCD), SULFATE ION | | Authors: | Sablin, E.P, Case, R.B, Dai, S.C, Hart, C.L, Ruby, A, Vale, R.D, Fletterick, R.J. | | Deposit date: | 1999-06-04 | | Release date: | 1999-06-09 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Direction determination in the minus-end-directed kinesin motor ncd.
Nature, 395, 1998
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2R29
 | | Neutralization of dengue virus by a serotype cross-reactive antibody elucidated by cryoelectron microscopy and x-ray crystallography | | Descriptor: | Envelope protein E, Heavy chain of Fab 1A1D-2, Light chain of Fab 1A1D-2 | | Authors: | Lok, S.M, Kostyuchenko, V.K, Nybakken, G.E, Holdaway, H.A, Battisti, A.J, Sukupolvi-petty, S, Sedlak, D, Fremont, D.H, Chipman, P.R, Roehrig, J.T, Diamond, M.S, Kuhn, R.J, Rossmann, M.G. | | Deposit date: | 2007-08-24 | | Release date: | 2007-12-25 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins.
Nat.Struct.Mol.Biol., 15, 2008
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