5WBN
Crystal structure of fragment 3-(3-Benzyl-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain
Summary for 5WBN
Entry DOI | 10.2210/pdb5wbn/pdb |
Descriptor | Histone deacetylase 6, ZINC ION, 3-(3-benzyl-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)propanoic acid, ... (8 entities in total) |
Functional Keywords | histone deacetylase, hdac, hdac6, fragment screening, structural genomics consortium, sgc, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: Q9UBN7 |
Total number of polymer chains | 1 |
Total formula weight | 16264.94 |
Authors | Harding, R.J.,Walker, J.R.,Ferreira de Freitas, R.,Ravichandran, M.,Santhakumar, V.,Schapira, M.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H. (deposition date: 2017-06-29, release date: 2017-08-02, Last modification date: 2024-03-13) |
Primary citation | Harding, R.J.,Walker, J.R.,Ferreira de Freitas, R.,Ravichandran, M.,Santhakumar, V.,Schapira, M.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H. Crystal structure of fragment 3-(3-Benzyl-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain To be published, |
Experimental method | X-RAY DIFFRACTION (1.64 Å) |
Structure validation
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