5WBN

Crystal structure of fragment 3-(3-Benzyl-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain

Summary for 5WBN

• Entry DOI: 10.2210/pdb5wbn/pdb
• Descriptor: Histone deacetylase 6, ZINC ION, 3-(3-benzyl-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)propanoic acid, ... (8 entities in total)
• Functional Keywords: histone deacetylase, hdac, hdac6, fragment screening, structural genomics consortium, sgc, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: Q9UBN7
• Total number of polymer chains: 1
• Total formula weight: 16264.94

Authors

Harding, R.J.,Walker, J.R.,Ferreira de Freitas, R.,Ravichandran, M.,Santhakumar, V.,Schapira, M.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H. (deposition date: 2017-06-29, release date: 2017-08-02, Last modification date: 2024-03-13)

• Primary citation: Harding, R.J.,Walker, J.R.,Ferreira de Freitas, R.,Ravichandran, M.,Santhakumar, V.,Schapira, M.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.; Crystal structure of fragment 3-(3-Benzyl-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain; To be published,

Experimental method

X-RAY DIFFRACTION (1.64 Å)