5WBN
Crystal structure of fragment 3-(3-Benzyl-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1301 |
| Chain | Residue |
| A | CYS1145 |
| A | CYS1148 |
| A | HIS1164 |
| A | HIS1170 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1302 |
| Chain | Residue |
| A | CYS1133 |
| A | CYS1136 |
| A | CYS1153 |
| A | HIS1160 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1303 |
| Chain | Residue |
| A | HIS1115 |
| A | CYS1183 |
| A | CYS1186 |
| A | CYS1113 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for residue 9ZV A 1304 |
| Chain | Residue |
| A | TRP1143 |
| A | GLY1154 |
| A | ARG1155 |
| A | TRP1182 |
| A | TYR1184 |
| A | TYR1189 |
| A | LEU1196 |
| A | ASN1200 |
| A | GLN1204 |
| A | GLU1209 |
| A | HOH1423 |
| A | HOH1427 |
| A | HOH1429 |
| A | HOH1444 |
| A | HOH1450 |
| A | HOH1451 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue FMT A 1313 |
| Chain | Residue |
| A | TRP1143 |
| A | ILE1177 |
| A | HOH1419 |
| A | HOH1423 |
| A | HOH1424 |
| A | HOH1491 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue FMT A 1314 |
| Chain | Residue |
| A | PRO1109 |
| A | SER1180 |
| A | TYR1189 |
| A | HIS1191 |
| A | HOH1418 |
| A | HOH1445 |
| A | HOH1475 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue FMT A 1315 |
| Chain | Residue |
| A | GLU1141 |
| A | TYR1156 |
| A | HIS1191 |
| A | HIS1192 |
| A | LEU1195 |
| A | LYS1199 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 1316 |
| Chain | Residue |
| A | ALA1124 |
| A | ALA1125 |
| A | HOH1490 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue ACT A 1317 |
| Chain | Residue |
| A | TRP1112 |
| A | HOH1431 |
| A | HOH1452 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue ACT A 1318 |
| Chain | Residue |
| A | ASP1135 |
| A | TYR1152 |
| A | HIS1160 |
| A | GLN1163 |
| A | HIS1164 |
| A | ASN1167 |
| A | HOH1407 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 98 |
| Details | Zinc finger: {"description":"UBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00502","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Region: {"description":"Ubiquitin binding","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human HDAC6 zinc finger domain and ubiquitin C-terminal peptide RLRGG.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00502","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"PDB data bank","title":"Crystal structure of human HDAC6 zinc finger domain.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human HDAC6 zinc finger domain and ubiquitin C-terminal peptide RLRGG.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
