6N9K
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![BU of 6n9k by Molmil](/molmil-images/mine/6n9k) | Beta-lactamase from Escherichia coli str. Sakai | Descriptor: | 1,2-ETHANEDIOL, Beta-lactamase, GLYCEROL, ... | Authors: | Osipiuk, J, Wu, R, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2018-12-03 | Release date: | 2018-12-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Beta-lactamase from Escherichia coli str. Sakai to be published
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5YUK
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5NE6
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1U9L
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![BU of 1u9l by Molmil](/molmil-images/mine/1u9l) | Structural basis for a NusA- protein N interaction | Descriptor: | GOLD ION, Lambda N, Transcription elongation protein nusA | Authors: | Bonin, I, Muehlberger, R, Bourenkov, G.P, Huber, R, Bacher, A, Richter, G, Wahl, M.C. | Deposit date: | 2004-08-10 | Release date: | 2004-08-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for the interaction of Escherichia coli NusA with protein N of phage lambda Proc.Natl.Acad.Sci.Usa, 101, 2004
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6MXS
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![BU of 6mxs by Molmil](/molmil-images/mine/6mxs) | Crystal structure of the dimeric bH1-Fab variant [HC-Y33W,HC-D98F,HC-G99M] | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, SODIUM ION, ... | Authors: | Shi, R, Picard, M.-E, Manenda, M.S. | Deposit date: | 2018-10-31 | Release date: | 2019-07-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Binding symmetry and surface flexibility mediate antibody self-association. Mabs, 11, 2019
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6NAZ
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![BU of 6naz by Molmil](/molmil-images/mine/6naz) | Crystal structure of DIRAS 2/3 chimera in complex with GDP | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, GTP-binding protein Di-Ras2,GTP-binding protein Di-Ras3,GTP-binding protein Di-Ras2, ... | Authors: | Gilbert, Y.H, Reger, A, Sharma, R, Bast, J, Kim, C. | Deposit date: | 2018-12-06 | Release date: | 2019-12-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.081 Å) | Cite: | Crystal structure of DIRAS 2/3 chimera in complex with GDP To Be Published
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6NB3
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![BU of 6nb3 by Molmil](/molmil-images/mine/6nb3) | MERS-CoV complex with human neutralizing LCA60 antibody Fab fragment (state 1) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LCA60 heavy chain, ... | Authors: | Walls, A.C, Xiong, X, Park, Y.J, Tortorici, M.A, Snijder, S, Quispe, J, Cameroni, E, Gopal, R, Mian, D, Lanzavecchia, A, Zambon, M, Rey, F.A, Corti, D, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | Deposit date: | 2018-12-06 | Release date: | 2019-02-06 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion. Cell, 176, 2019
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5MZZ
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![BU of 5mzz by Molmil](/molmil-images/mine/5mzz) | Crystal structure of the decarboxylase AibA/AibB in complex with 3-methylglutaconate | Descriptor: | 3-methylpent-2-enedioic acid, ACETATE ION, GLYCEROL, ... | Authors: | Bock, T, Luxenburger, E, Hoffmann, J, Schuetza, V, Feiler, C, Mueller, R, Blankenfeldt, W. | Deposit date: | 2017-02-02 | Release date: | 2017-05-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus xanthus. Angew. Chem. Int. Ed. Engl., 56, 2017
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4MZW
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![BU of 4mzw by Molmil](/molmil-images/mine/4mzw) | CRYSTAL STRUCTURE OF NU-CLASS GLUTATHIONE TRANSFERASE YGHU FROM Streptococcus sanguinis SK36, COMPLEX WITH GLUTATHIONE DISULFIDE, TARGET EFI-507286 | Descriptor: | ACETATE ION, Glutathione S-Transferase, OXIDIZED GLUTATHIONE DISULFIDE | Authors: | Patskovsky, Y, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Imker, H.J, Al Obaidi, N, Stead, M, Love, J, Gerlt, J.A, Armstrong, R.N, Almo, S.C, Enzyme Function Initiative (EFI) | Deposit date: | 2013-09-30 | Release date: | 2013-10-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal Structure of Glutathione S-Transferase Yghu (Target Efi-507286) To be Published
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3RK5
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![BU of 3rk5 by Molmil](/molmil-images/mine/3rk5) | CDK2 in complex with inhibitor RC-2-72 | Descriptor: | 4-{[4-amino-5-(pyridin-3-ylcarbonyl)-1,3-thiazol-2-yl]amino}benzoic acid, Cyclin-dependent kinase 2 | Authors: | Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. | Deposit date: | 2011-04-17 | Release date: | 2012-10-31 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
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6NF8
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![BU of 6nf8 by Molmil](/molmil-images/mine/6nf8) | Structure of human mitochondrial translation initiation factor 3 bound to the small ribosomal subunit -Class I | Descriptor: | 28S ribosomal RNA, mitochondria, 28S ribosomal protein S10, ... | Authors: | Sharma, M, Koripella, R, Agrawal, R. | Deposit date: | 2018-12-19 | Release date: | 2019-02-27 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.48 Å) | Cite: | Structure of Human Mitochondrial Translation Initiation Factor 3 Bound to the Small Ribosomal Subunit. iScience, 12, 2019
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3DPF
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![BU of 3dpf by Molmil](/molmil-images/mine/3dpf) | Crystal structure of the complex between MMP-8 and a non-zinc chelating inhibitor | Descriptor: | ACETOHYDROXAMIC ACID, CALCIUM ION, N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]methyl}-4-oxo-3,5,6,8-tetrahydro-4H-thiopyrano[4',3':4,5]thieno[2,3-d]pyrimidine-2-carboxamide 7,7-dioxide, ... | Authors: | Pochetti, G, Montanari, R, Mazza, F. | Deposit date: | 2008-07-08 | Release date: | 2009-03-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S(1)' Subsite of Matrix Metalloproteinase 8 (MMP-8) J.Med.Chem., 52, 2009
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4J9X
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![BU of 4j9x by Molmil](/molmil-images/mine/4j9x) | Crystal structure of the complex of a hydroxyproline epimerase (TARGET EFI-506499, PSEUDOMONAS FLUORESCENS PF-5) with trans-4-hydroxy-l-proline | Descriptor: | 4-HYDROXYPROLINE, Proline racemase family protein, SODIUM ION | Authors: | Vetting, M.W, Toro, R, Bhosle, R, Al Obaidi, N.F, Morisco, L.L, Wasserman, S.R, Sojitra, S, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Stead, M, Hillerich, B, Love, J, Seidel, R.D, Imker, H.J, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | Deposit date: | 2013-02-17 | Release date: | 2013-03-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of the complex of a hydroxyproline epimerase (TARGET EFI-506499, PSEUDOMONAS FLUORESCENS PF-5) with trans-4-hydroxy-l-proline To be Published
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3RPR
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![BU of 3rpr by Molmil](/molmil-images/mine/3rpr) | CDK2 in complex with inhibitor RC-2-49 | Descriptor: | Cyclin-dependent kinase 2, [4-amino-2-(phenylamino)-1,3-thiazol-5-yl][3-(trifluoromethyl)phenyl]methanone | Authors: | Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. | Deposit date: | 2011-04-27 | Release date: | 2012-10-31 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
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3RPY
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![BU of 3rpy by Molmil](/molmil-images/mine/3rpy) | CDK2 in complex with inhibitor RC-2-40 | Descriptor: | 4-amino-2-[(4-sulfamoylphenyl)amino]-1,3-thiazole-5-carboxamide, Cyclin-dependent kinase 2 | Authors: | Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. | Deposit date: | 2011-04-27 | Release date: | 2012-10-31 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
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5NCI
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![BU of 5nci by Molmil](/molmil-images/mine/5nci) | GriE in complex with cobalt, alpha-ketoglutarate and l-leucine | Descriptor: | 2-OXOGLUTARIC ACID, COBALT (II) ION, LEUCINE, ... | Authors: | Lukat, P, Blankenfeldt, W, Mueller, R. | Deposit date: | 2017-03-05 | Release date: | 2017-10-04 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.755 Å) | Cite: | Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity. Chem Sci, 8, 2017
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5NE7
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6NKC
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![BU of 6nkc by Molmil](/molmil-images/mine/6nkc) | Crystal Structure of the Lipase Lip_vut1 from Goat Rumen metagenome. | Descriptor: | 1,2-ETHANEDIOL, AZIDE ION, CHLORIDE ION, ... | Authors: | Kim, Y, Welk, L, Mukendi, G, Nkhi, G, Motloi, T, Jedrzejczak, R, Feto, N, Joachimiak, A. | Deposit date: | 2019-01-07 | Release date: | 2020-01-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.631 Å) | Cite: | Crystal Structure of the Lipase Lip_vut1 from Goat Rumen metagenome. To Be Published
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6NKG
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![BU of 6nkg by Molmil](/molmil-images/mine/6nkg) | Crystal Structure of the Lipase Lip_vut5 from Goat Rumen metagenome. | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, Lip_vut5, ... | Authors: | Kim, Y, Welk, L, Mukendi, G, Nkhi, G, Motloi, T, Jedrzejczak, R, Feto, N, Joachimiak, A. | Deposit date: | 2019-01-07 | Release date: | 2020-01-22 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal Structure of the Lipase Lip_vut5 from Goat Rumen metagenome. To Be Published
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6NM5
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![BU of 6nm5 by Molmil](/molmil-images/mine/6nm5) | F-pilus/MS2 Maturation protein complex | Descriptor: | (2R)-2,3-dihydroxypropyl ethyl hydrogen (S)-phosphate, Maturation protein, Type IV conjugative transfer system pilin TraA | Authors: | Meng, R, Chang, J, Zhang, J. | Deposit date: | 2019-01-10 | Release date: | 2019-07-24 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (6.2 Å) | Cite: | Structural basis for the adsorption of a single-stranded RNA bacteriophage. Nat Commun, 10, 2019
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4R15
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![BU of 4r15 by Molmil](/molmil-images/mine/4r15) | High-resolution crystal structure of Z-DNA in complex with Cr3+ cations | Descriptor: | CHROMIUM ION, DNA (5'-D(*CP*GP*CP*GP*CP*G)-3') | Authors: | Drozdzal, P, Gilski, M, Kierzek, R, Lomozik, L, Jaskolski, M. | Deposit date: | 2014-08-04 | Release date: | 2015-03-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (0.97 Å) | Cite: | High-resolution crystal structure of Z-DNA in complex with Cr(3+) cations. J.Biol.Inorg.Chem., 20, 2015
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3R8Z
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![BU of 3r8z by Molmil](/molmil-images/mine/3r8z) | CDK2 in complex with inhibitor RC-1-136 | Descriptor: | Cyclin-dependent kinase 2, [4-amino-2-(prop-2-en-1-ylamino)-1,3-thiazol-5-yl](pyridin-4-yl)methanone | Authors: | Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. | Deposit date: | 2011-03-24 | Release date: | 2012-10-31 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
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7JUO
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![BU of 7juo by Molmil](/molmil-images/mine/7juo) | CBP bromodomain complexed with YF2-23 | Descriptor: | CREB-binding protein, N-{1-[1,1-di(pyridin-2-yl)ethyl]-6-(1-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-3-yl)-1H-indol-4-yl}ethanesulfonamide | Authors: | Ratia, K.M, Xiong, R, Principe, D, Li, Y, Huang, F, Rana, A, Thatcher, G. | Deposit date: | 2020-08-20 | Release date: | 2021-09-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer. Proc.Natl.Acad.Sci.USA, 119, 2022
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3RAK
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![BU of 3rak by Molmil](/molmil-images/mine/3rak) | CDK2 in complex with inhibitor RC-2-32 | Descriptor: | 4-[(4-amino-5-benzoyl-1,3-thiazol-2-yl)amino]benzenesulfonamide, Cyclin-dependent kinase 2 | Authors: | Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. | Deposit date: | 2011-03-28 | Release date: | 2012-10-31 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
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6NEQ
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![BU of 6neq by Molmil](/molmil-images/mine/6neq) | Structure of human mitochondrial translation initiation factor 3 bound to the small ribosomal subunit-Class-II | Descriptor: | 28S ribosomal RNA, mitochondrial, 28S ribosomal protein S10, ... | Authors: | Sharma, M, Koripella, R, Agrawal, R. | Deposit date: | 2018-12-18 | Release date: | 2019-02-27 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Structure of Human Mitochondrial Translation Initiation Factor 3 Bound to the Small Ribosomal Subunit. iScience, 12, 2019
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