3DPF
Crystal structure of the complex between MMP-8 and a non-zinc chelating inhibitor
Summary for 3DPF
Entry DOI | 10.2210/pdb3dpf/pdb |
Related | 1XUC 1XUD 1XUR 3DNG 3DPE |
Descriptor | Neutrophil collagenase, CALCIUM ION, ZINC ION, ... (6 entities in total) |
Functional Keywords | hydrolase, selective inhibition, non-zinc chelating inhibitors, calcium, collagen degradation, extracellular matrix, glycoprotein, metal-binding, metalloprotease, polymorphism, protease, secreted, zinc, zymogen |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasmic granule: P22894 |
Total number of polymer chains | 2 |
Total formula weight | 37799.67 |
Authors | Pochetti, G.,Montanari, R.,Mazza, F. (deposition date: 2008-07-08, release date: 2009-03-03, Last modification date: 2023-11-01) |
Primary citation | Pochetti, G.,Montanari, R.,Gege, C.,Chevrier, C.,Taveras, A.G.,Mazza, F. Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S(1)' Subsite of Matrix Metalloproteinase 8 (MMP-8) J.Med.Chem., 52:1040-1049, 2009 Cited by PubMed: 19173605DOI: 10.1021/jm801166j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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