3DPF
Crystal structure of the complex between MMP-8 and a non-zinc chelating inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Neutrophil collagenase | polymer | 163 | 18111.7 | 2 | UniProt (P22894) Pfam (PF00413) | Homo sapiens (Human) | Matrix metalloproteinase-8, MMP-8, PMNL collagenase, PMNL-CL |
| 2 | C, D, I, J (A, B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 3 | E, F, K, L (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | G, M (A, B) | N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]methyl}-4-oxo-3,5,6,8-tetrahydro-4H-thiopyrano[4',3':4,5]thieno[2,3-d]pyrimidine-2-carboxamide 7,7-dioxide | non-polymer | 539.6 | 2 | Chemie (AXB) | |||
| 5 | H (A) | ACETOHYDROXAMIC ACID | non-polymer | 75.1 | 1 | Chemie (HAE) | |||
| 6 | N, O (A, B) | water | water | 18.0 | 426 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36223.5 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1576.2 | |
| All* | Total formula weight | 37799.7 |
