Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 63 results

4PYU
DownloadVisualize
BU of 4pyu by Molmil
The conserved ubiquitin-like protein hub1 plays a critical role in splicing in human cells
Descriptor: U4/U6.U5 tri-snRNP-associated protein 1, Ubiquitin-like protein 5
Authors:Ammon, T, Mishra, S.K, Kowalska, K, Popowicz, G.M, Holak, T.A, Jentsch, S.
Deposit date:2014-03-28
Release date:2014-07-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells.
J Mol Cell Biol, 6, 2014
3JU0
DownloadVisualize
BU of 3ju0 by Molmil
Structure of the arm-type binding domain of HAI7 integrase
Descriptor: Phage integrase
Authors:Szwagierczak, A, Antonenka, U, Popowicz, G.M, Sitar, T, Holak, T.A, Rakin, A.
Deposit date:2009-09-14
Release date:2009-10-06
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of the arm-type binding domains of HPI and HAI7 integrases
J.Biol.Chem., 284, 2009
3JTZ
DownloadVisualize
BU of 3jtz by Molmil
Structure of the arm-type binding domain of HPI integrase
Descriptor: Integrase, SODIUM ION
Authors:Szwagierczak, A, Antonenka, U, Popowicz, G.M, Sitar, T, Holak, T.A, Rakin, A.
Deposit date:2009-09-14
Release date:2009-10-06
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structures of the arm-type binding domains of HPI and HAI7 integrases
J.Biol.Chem., 284, 2009
4QQB
DownloadVisualize
BU of 4qqb by Molmil
Structural basis for the assembly of the SXL-UNR translation regulatory complex
Descriptor: Protein sex-lethal, Upstream of N-ras, isoform A, ...
Authors:Hennig, J, Popowicz, G.M, Sattler, M.
Deposit date:2014-06-27
Release date:2014-09-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for the assembly of the Sxl-Unr translation regulatory complex.
Nature, 515, 2014
3V3B
DownloadVisualize
BU of 3v3b by Molmil
Structure of the Stapled p53 Peptide Bound to Mdm2
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, SAH-p53-8 stapled-peptide
Authors:Baek, S, Kutchukian, P.S, Verdine, G.L, Huber, R, Holak, T.A, Ki Won, L, Popowicz, G.M.
Deposit date:2011-12-13
Release date:2012-01-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the stapled p53 peptide bound to Mdm2.
J.Am.Chem.Soc., 134, 2012
3V3V
DownloadVisualize
BU of 3v3v by Molmil
Structural and functional analysis of quercetagetin, a natural JNK1 inhibitor
Descriptor: 3,5,6,7-TETRAHYDROXY-2-(3,4-DIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, C-Jun-amino-terminal kinase-interacting protein 1, CHLORIDE ION, ...
Authors:Baek, S, Kang, N.J, Popowicz, G.M, Arciniega, M, Jung, S.K, Byun, S, Song, N.R, Heo, Y.S, Kim, B.Y, Lee, H.J, Holak, T.A, Augustin, M, Bode, A.M, Huber, R, Dong, Z, Lee, K.W.
Deposit date:2011-12-14
Release date:2012-12-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Functional Analysis of the Natural JNK1 Inhibitor Quercetagetin.
J.Mol.Biol., 425, 2013
7NDX
DownloadVisualize
BU of 7ndx by Molmil
Crystal structure of the human HSP40 DNAJB1-CTDs in complex with a peptide of NudC
Descriptor: 1,2-ETHANEDIOL, DnaJ homolog subfamily B member 1, Nuclear migration protein nudC
Authors:Delhommel, F, Zak, K.M, Popowicz, G.M, Sattler, M.
Deposit date:2021-02-02
Release date:2022-01-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.541 Å)
Cite:NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems.
Mol.Cell, 82, 2022
2GRC
DownloadVisualize
BU of 2grc by Molmil
1.5 A structure of bromodomain from human BRG1 protein, a central ATPase of SWI/SNF remodeling complex
Descriptor: Probable global transcription activator SNF2L4
Authors:Singh, M, Popowicz, G.M, Krajewski, M, Holak, T.A.
Deposit date:2006-04-24
Release date:2007-05-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein, a central ATPase of the SWI/SNF remodeling complex.
Chembiochem, 8, 2007
3FDO
DownloadVisualize
BU of 3fdo by Molmil
Structure of human MDMX in complex with high affinity peptide
Descriptor: MAGNESIUM ION, Protein Mdm4, Synthetic high affinity peptide
Authors:Czarna, A.L, Popowicz, G.M, Holak, T.A.
Deposit date:2008-11-26
Release date:2008-12-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx.
Cell Cycle, 8, 2009
3G03
DownloadVisualize
BU of 3g03 by Molmil
Structure of human MDM2 in complex with high affinity peptide
Descriptor: E3 ubiquitin-protein ligase Mdm2, High affinity synthetic peptide
Authors:Czarna, A.L, Popowicz, G.M, Holak, T.A.
Deposit date:2009-01-27
Release date:2009-04-14
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx.
Cell Cycle, 8, 2009
2ABZ
DownloadVisualize
BU of 2abz by Molmil
Crystal structure of C19A/C43A mutant of leech carboxypeptidase inhibitor in complex with bovine carboxypeptidase A
Descriptor: Carboxypeptidase A1, Metallocarboxypeptidase inhibitor, ZINC ION
Authors:Arolas, J.L, Popowicz, G.M, Bronsoms, S, Aviles, F.X, Huber, R, Holak, T.A, Ventura, S.
Deposit date:2005-07-18
Release date:2006-01-31
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Study of a major intermediate in the oxidative folding of leech carboxypeptidase inhibitor: contribution of the fourth disulfide bond
J.Mol.Biol., 352, 2005
7R2V
DownloadVisualize
BU of 7r2v by Molmil
Structure of nsp14 from SARS-CoV-2 in complex with SAH
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, Proofreading exoribonuclease nsp14, ...
Authors:Czarna, A, Plewka, J, Kresik, L, Matsuda, A, Abdulkarim, K, Robinson, C, OByrne, S, Cunningham, F, Georgiou, I, Pachota, M, Popowicz, G.M, Wyatt, P.G, Dubin, G, Pyrc, K.
Deposit date:2022-02-06
Release date:2022-03-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity.
Structure, 30, 2022
3PLU
DownloadVisualize
BU of 3plu by Molmil
Structure of Hub-1 protein in complex with Snu66 peptide (HINDI)
Descriptor: 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component, Ubiquitin-like modifier HUB1
Authors:Mishra, S.K, Ammon, T, Popowicz, G.M, Krajewski, M, Nagel, R.J, Ares, M, Holak, T.A, Jentsch, S.
Deposit date:2010-11-15
Release date:2011-06-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing.
Nature, 474, 2011
6F8G
DownloadVisualize
BU of 6f8g by Molmil
Co-crystal structure of SPOP MATH domain and hamster Pdx1 fragment
Descriptor: Pancreas/duodenum homeobox protein 1, Speckle-type POZ protein
Authors:Ostertag, M.S, Popowicz, G.M, Sattler, M.
Deposit date:2017-12-13
Release date:2018-11-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:The Structure of the SPOP-Pdx1 Interface Reveals Insights into the Phosphorylation-Dependent Binding Regulation.
Structure, 27, 2019
3PLV
DownloadVisualize
BU of 3plv by Molmil
Structure of Hub-1 protein in complex with Snu66 peptide (HINDII)
Descriptor: 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component, Ubiquitin-like modifier HUB1
Authors:Mishra, S.K, Ammon, T, Popowicz, G.M, Krajewski, M, Nagel, R.J, Ares, M, Holak, T.A, Jentsch, S.
Deposit date:2010-11-15
Release date:2011-06-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing.
Nature, 474, 2011
6F8F
DownloadVisualize
BU of 6f8f by Molmil
Co-crystal structure of SPOP MATH domain and human Pdx1 fragment
Descriptor: Pancreas/duodenum homeobox protein 1, Speckle-type POZ protein
Authors:Ostertag, M.S, Popowicz, G.M, Sattler, M.
Deposit date:2017-12-13
Release date:2018-11-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Structure of the SPOP-Pdx1 Interface Reveals Insights into the Phosphorylation-Dependent Binding Regulation.
Structure, 27, 2019
3RMP
DownloadVisualize
BU of 3rmp by Molmil
Structural basis for the recognition of attP substrates by P4-like integrases
Descriptor: 5'-D(*TP*AP*AP*TP*GP*AP*CP*CP*AP*CP*CP*AP*AP*TP*A)-3', 5'-D(*TP*AP*TP*TP*GP*GP*TP*GP*GP*TP*CP*AP*TP*TP*A)-3', CP4-like integrase
Authors:Szwagierczak, A, Popowicz, G.M, Holak, T.A, Rakin, A, Antonenka, U.
Deposit date:2011-04-21
Release date:2012-04-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structural basis for the recognition of attP substrates by P4-like integrases
To be Published
3TJ2
DownloadVisualize
BU of 3tj2 by Molmil
Structure of a novel submicromolar MDM2 inhibitor
Descriptor: 3-{(1S)-2-(tert-butylamino)-1-[(4-chlorobenzyl)(formyl)amino]-2-oxoethyl}-6-chloro-1H-indole-2-carboxylic acid, E3 ubiquitin-protein ligase Mdm2, POTASSIUM ION
Authors:Wolf, S, Huang, Y, Popowicz, G.M, Goda, S, Holak, T.A, Doemling, A.
Deposit date:2011-08-23
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Ugi Multicomponent Reaction Derived p53-Mdm2 Antagonists
To be published
3UFA
DownloadVisualize
BU of 3ufa by Molmil
Crystal structure of the staphylococcal serine protease SplA in complex with a specific phosphonate inhibitor
Descriptor: CHLORIDE ION, N-(3-carboxypropanoyl)-L-valyl-N-[(1S)-2-phenyl-1-phosphonoethyl]-L-prolinamide, Serine protease splA
Authors:Zdzalik, M, Pietrusewicz, E, Pustelny, K, Stec-Niemczyk, J, Popowicz, G.M, Potempa, J, Oleksyszyn, J, Dubin, G.
Deposit date:2011-10-31
Release date:2013-01-23
Last modified:2014-03-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus.
Protein Sci., 23, 2014
6RZS
DownloadVisualize
BU of 6rzs by Molmil
Structure of IMP-13 metallo-beta-lactamase complexed with hydrolysed ertapenem
Descriptor: Beta-lactamase, ZINC ION, hydrolysed ertapenem
Authors:Zak, K.M, Softley, C, Kolonko, M, Sattler, M, Popowicz, G.M.
Deposit date:2019-06-13
Release date:2020-04-01
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and Molecular Recognition Mechanism of IMP-13 Metallo-beta-Lactamase.
Antimicrob.Agents Chemother., 64, 2020
6S0H
DownloadVisualize
BU of 6s0h by Molmil
Structure of IMP-13 metallo-beta-lactamase complexed with hydrolysed doripenem
Descriptor: (2~{R},3~{R})-2-[(2~{S},3~{R})-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-3-methyl-4-[(3~{S},5~{S})-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-2,3-dihydro-1~{H}-pyrrole-5-carboxylic acid, 1,2-ETHANEDIOL, Beta-lactamase, ...
Authors:Zak, K.M, Softley, C, Kolonko, M, Sattler, M, Popowicz, G.M.
Deposit date:2019-06-14
Release date:2020-04-01
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure and Molecular Recognition Mechanism of IMP-13 Metallo-beta-Lactamase.
Antimicrob.Agents Chemother., 64, 2020
6RZR
DownloadVisualize
BU of 6rzr by Molmil
Structure of IMP-13 metallo-beta-lactamase complexed with hydrolysed imipenem
Descriptor: (2R)-2-[(2S,3R)-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-(2-methanimidamidoethylsulfanyl)-2,3-dihydro-1H-pyrrole -5-carboxylic acid, 1,2-ETHANEDIOL, Beta-lactamase, ...
Authors:Zak, K.M, Softley, C, Kolonko, M, Sattler, M, Popowicz, G.M.
Deposit date:2019-06-13
Release date:2020-04-01
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and Molecular Recognition Mechanism of IMP-13 Metallo-beta-Lactamase.
Antimicrob.Agents Chemother., 64, 2020
6SPT
DownloadVisualize
BU of 6spt by Molmil
High resolution crystal structure of N-terminal domain of PEX14 from Trypanosoma brucei in complex with the fist compound with sub-micromolar trypanocidal activity
Descriptor: 5-[(4-methoxynaphthalen-1-yl)methyl]-1-[2-[(2-methyl-1-oxidanyl-propan-2-yl)amino]ethyl]-~{N}-(naphthalen-1-ylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide, BETA-MERCAPTOETHANOL, CHLORIDE ION, ...
Authors:Napolitano, V, Dawidowski, M, Kalel, V.C, Fino, R, Emmanouilidis, L, Lenhart, D, Ostertag, M, Kaiser, M, Kolonko, M, Schilebs, W, Maser, P, Tetko, I, Hadian, K, Plettenburg, O, Erdmann, R, Sattler, M, Popowicz, G.M, Dubin, G.
Deposit date:2019-09-02
Release date:2020-01-01
Last modified:2020-02-05
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity.
J.Med.Chem., 63, 2020
1WQJ
DownloadVisualize
BU of 1wqj by Molmil
Structural Basis for the Regulation of Insulin-Like Growth Factors (IGFs) by IGF Binding Proteins (IGFBPs)
Descriptor: Insulin-like growth factor IB, Insulin-like growth factor binding protein 4
Authors:Siwanowicz, I, Popowicz, G.M, Wisniewska, M, Huber, R, Kuenkele, K.P, Lang, K, Engh, R.A, Holak, T.A.
Deposit date:2004-09-29
Release date:2005-03-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis for the regulation of insulin-like growth factors by IGF binding proteins
Structure, 13, 2005
1ZFI
DownloadVisualize
BU of 1zfi by Molmil
Solution structure of the leech carboxypeptidase inhibitor
Descriptor: Metallocarboxypeptidase inhibitor
Authors:Arolas, J.L, D'Silva, L, Popowicz, G.M, Aviles, F.X, Holak, T.A, Ventura, S.
Deposit date:2005-04-20
Release date:2005-09-13
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor
STRUCTURE, 13, 2005

221051

数据于2024-06-12公开中

PDB statisticsPDBj update infoContact PDBjnumon