7MOW
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![BU of 7mow by Molmil](/molmil-images/mine/7mow) | PTP1B F225I in complex with TCS401 | Descriptor: | 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | Authors: | Torgeson, K.R, Page, R, Peti, W. | Deposit date: | 2021-05-03 | Release date: | 2022-05-18 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Conserved conformational dynamics determine enzyme activity. Sci Adv, 8, 2022
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7MOV
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![BU of 7mov by Molmil](/molmil-images/mine/7mov) | PTP1B 1-301 F225Y-R199N mutations | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ... | Authors: | Torgeson, K.R, Page, R, Peti, W. | Deposit date: | 2021-05-03 | Release date: | 2022-05-18 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Conserved conformational dynamics determine enzyme activity. Sci Adv, 8, 2022
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3O9X
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![BU of 3o9x by Molmil](/molmil-images/mine/3o9x) | Structure of the E. coli antitoxin MqsA (YgiT/b3021) in complex with its gene promoter | Descriptor: | DNA (26-MER), GLYCEROL, Uncharacterized HTH-type transcriptional regulator ygiT, ... | Authors: | Brown, B.L, Peti, W, Page, R. | Deposit date: | 2010-08-04 | Release date: | 2010-11-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.0999 Å) | Cite: | Structure of the Escherichia coli Antitoxin MqsA (YgiT/b3021) Bound to Its Gene Promoter Reveals Extensive Domain Rearrangements and the Specificity of Transcriptional Regulation. J.Biol.Chem., 286, 2011
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1WCJ
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![BU of 1wcj by Molmil](/molmil-images/mine/1wcj) | Conserved Hypothetical Protein TM0487 from Thermotoga maritima | Descriptor: | HYPOTHETICAL PROTEIN TM0487 | Authors: | Almeida, M.S, Peti, W, Herrmann, T, Wuthrich, K, Joint Center for Structural Genomics (JCSG) | Deposit date: | 2004-11-17 | Release date: | 2004-12-14 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR Structure of the Conserved Hypothetical Protein Tm0487 from Thermotoga Maritima: Implications for 216 Homologous Duf59 Proteins. Protein Sci., 14, 2005
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6UUQ
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![BU of 6uuq by Molmil](/molmil-images/mine/6uuq) | Structure of Calcineurin bound to RCAN1 | Descriptor: | Calcipressin-1, FE (III) ION, PHOSPHATE ION, ... | Authors: | Sheftic, S, Page, R, Peti, W. | Deposit date: | 2019-10-31 | Release date: | 2020-09-09 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.849 Å) | Cite: | The structure of the RCAN1:CN complex explains the inhibition of and substrate recruitment by calcineurin. Sci Adv, 6, 2020
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6VRO
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![BU of 6vro by Molmil](/molmil-images/mine/6vro) | The structure of the PP2A B56 subunit AIM1 complex | Descriptor: | Beta/gamma crystallin domain-containing protein 1, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | Authors: | Wang, X, Page, R, Peti, W. | Deposit date: | 2020-02-08 | Release date: | 2020-03-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment. Elife, 9, 2020
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4Y14
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![BU of 4y14 by Molmil](/molmil-images/mine/4y14) | Structure of protein tyrosine phosphatase 1B complexed with inhibitor (PTP1B:CPT157633) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-bromo-4-[difluoro(phosphono)methyl]-N-methyl-Nalpha-(methylsulfonyl)-L-phenylalaninamide, CHLORIDE ION, ... | Authors: | Choy, M.S, Connors, C, Page, R, Peti, W. | Deposit date: | 2015-02-06 | Release date: | 2015-08-05 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.898 Å) | Cite: | PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J.Clin.Invest., 125, 2015
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4P9F
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![BU of 4p9f by Molmil](/molmil-images/mine/4p9f) | E. coli McbR/YncC | Descriptor: | HTH-type transcriptional regulator mcbR | Authors: | Lord, D.M, Page, R, Peti, W. | Deposit date: | 2014-04-03 | Release date: | 2015-01-14 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | McbR/YncC: Implications for the Mechanism of Ligand and DNA Binding by a Bacterial GntR Transcriptional Regulator Involved in Biofilm Formation. Biochemistry, 53, 2014
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4F0Z
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![BU of 4f0z by Molmil](/molmil-images/mine/4f0z) | Crystal Structure of Calcineurin in Complex with the Calcineurin-Inhibiting Domain of the African Swine Fever Virus Protein A238L | Descriptor: | Ankyrin repeat domain-containing protein A238L, CALCIUM ION, Calcineurin subunit B type 1, ... | Authors: | Grigoriu, S, Peti, W, Page, R. | Deposit date: | 2012-05-05 | Release date: | 2013-03-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin. Plos Biol., 11, 2013
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4PHL
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![BU of 4phl by Molmil](/molmil-images/mine/4phl) | TbrPDEB1-inhibitor complex | Descriptor: | 3-(CYCLOPENTYLOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-METHOXYBENZAMIDE, Class 1 phosphodiesterase PDEB1, ETHANOL, ... | Authors: | Choy, M.S, Bland, N, Peti, W, Page, R. | Deposit date: | 2014-05-06 | Release date: | 2015-05-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | TbrPDEB1-inhibitor complex To Be Published
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8SW6
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![BU of 8sw6 by Molmil](/molmil-images/mine/8sw6) | |
6OBN
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![BU of 6obn by Molmil](/molmil-images/mine/6obn) | The crystal structure of coexpressed SDS22:PP1 complex | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, FE (III) ION, ... | Authors: | Choy, M.S, Moon, T.M, Bray, J.A, Archuleta, T.L, Shi, W, Peti, W, Page, R. | Deposit date: | 2019-03-21 | Release date: | 2019-09-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | SDS22 selectively recognizes and traps metal-deficient inactive PP1. Proc.Natl.Acad.Sci.USA, 116, 2019
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5SVE
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![BU of 5sve by Molmil](/molmil-images/mine/5sve) | Structure of Calcineurin in complex with NFATc1 LxVP peptide | Descriptor: | CALCIUM ION, Calcineurin subunit B type 1, FE (III) ION, ... | Authors: | Sheftic, S.R, Page, R, Peti, W. | Deposit date: | 2016-08-05 | Release date: | 2017-01-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.596 Å) | Cite: | Investigating the human Calcineurin Interaction Network using the pi LxVP SLiM. Sci Rep, 6, 2016
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4PCV
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![BU of 4pcv by Molmil](/molmil-images/mine/4pcv) | The structure of BdcA (YjgI) from E. coli | Descriptor: | BdcA (YjgI), PENTAETHYLENE GLYCOL, TRIETHYLENE GLYCOL | Authors: | Page, R, Peti, W, Lord, D. | Deposit date: | 2014-04-16 | Release date: | 2015-03-11 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | BdcA, a protein important for Escherichia coli biofilm dispersal, is a short-chain dehydrogenase/reductase that binds specifically to NADPH. Plos One, 9, 2014
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5SWF
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![BU of 5swf by Molmil](/molmil-images/mine/5swf) | The structure of the PP2A B56 subunit double phosphorylated BubR1 complex | Descriptor: | Double phosphorylated BubR1, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | Authors: | Page, R, Wang, X, Bajaj, R, Peti, W. | Deposit date: | 2016-08-08 | Release date: | 2016-11-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.818 Å) | Cite: | Expanding the PP2A Interactome by Defining a B56-Specific SLiM. Structure, 24, 2016
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5SW9
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![BU of 5sw9 by Molmil](/molmil-images/mine/5sw9) | The structure of the PP2A B56 subunit RepoMan complex | Descriptor: | RepoMan, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | Authors: | Page, R, Wang, X, Bajaj, R, Peti, W. | Deposit date: | 2016-08-08 | Release date: | 2016-11-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.846 Å) | Cite: | Expanding the PP2A Interactome by Defining a B56-Specific SLiM. Structure, 24, 2016
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4EWI
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![BU of 4ewi by Molmil](/molmil-images/mine/4ewi) | Crystal structure of the NLRP4 Pyrin domain | Descriptor: | CHLORIDE ION, NACHT, LRR and PYD domains-containing protein 4, ... | Authors: | Eibl, C, Hessenberger, M, Puehringer, S, Page, R, Diederichs, K, Peti, W. | Deposit date: | 2012-04-27 | Release date: | 2012-09-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structural and Functional Analysis of the NLRP4 Pyrin Domain. Biochemistry, 51, 2012
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6OBQ
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![BU of 6obq by Molmil](/molmil-images/mine/6obq) | PP1 H66K in complex with Microcystin LR | Descriptor: | MANGANESE (II) ION, Microcystin LR, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | Authors: | Choy, M.S, Moon, T.M, Bray, J.A, Archuleta, T.L, Shi, W, Peti, W, Page, R. | Deposit date: | 2019-03-21 | Release date: | 2019-09-18 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | SDS22 selectively recognizes and traps metal-deficient inactive PP1. Proc.Natl.Acad.Sci.USA, 116, 2019
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6OBP
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![BU of 6obp by Molmil](/molmil-images/mine/6obp) | Reconstituted PP1 holoenzyme | Descriptor: | CHLORIDE ION, MANGANESE (II) ION, PHOSPHATE ION, ... | Authors: | Choy, M.S, Moon, T.M, Bray, J.A, Archuleta, T.L, Shi, W, Peti, W, Page, R. | Deposit date: | 2019-03-21 | Release date: | 2019-09-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | SDS22 selectively recognizes and traps metal-deficient inactive PP1. Proc.Natl.Acad.Sci.USA, 116, 2019
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6OBU
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![BU of 6obu by Molmil](/molmil-images/mine/6obu) | PP1 Y134K in complex with Microcystin LR | Descriptor: | CHLORIDE ION, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Choy, M.S, Moon, T.M, Bray, J.A, Archuleta, T.L, Shi, W, Peti, W, Page, R. | Deposit date: | 2019-03-21 | Release date: | 2019-09-18 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | SDS22 selectively recognizes and traps metal-deficient inactive PP1. Proc.Natl.Acad.Sci.USA, 116, 2019
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6OBR
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![BU of 6obr by Molmil](/molmil-images/mine/6obr) | PP1 Y134A in complex with Microcystin LR | Descriptor: | CHLORIDE ION, MANGANESE (II) ION, Microcystin LR, ... | Authors: | Choy, M.S, Moon, T.M, Bray, J.A, Archuleta, T.L, Shi, W, Peti, W, Page, R. | Deposit date: | 2019-03-21 | Release date: | 2019-09-18 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | SDS22 selectively recognizes and traps metal-deficient inactive PP1. Proc.Natl.Acad.Sci.USA, 116, 2019
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8SO0
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![BU of 8so0 by Molmil](/molmil-images/mine/8so0) | Cryo-EM structure of the PP2A:B55-FAM122A complex | Descriptor: | FE (III) ION, PPP2R1A-PPP2R2A-interacting phosphatase regulator 1, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, ... | Authors: | Fuller, J.R, Padi, S.K.R, Peti, W, Page, R. | Deposit date: | 2023-04-28 | Release date: | 2023-10-25 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (2.79961 Å) | Cite: | Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19. Nature, 625, 2024
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3HI2
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![BU of 3hi2 by Molmil](/molmil-images/mine/3hi2) | Structure of the N-terminal domain of the E. coli antitoxin MqsA (YgiT/b3021) in complex with the E. coli toxin MqsR (YgiU/b3022) | Descriptor: | GLYCEROL, HTH-type transcriptional regulator mqsA(ygiT), Motility quorum-sensing regulator mqsR, ... | Authors: | Grigoriu, S, Brown, B.L, Arruda, J.M, Peti, W, Page, R. | Deposit date: | 2009-05-18 | Release date: | 2010-01-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Three dimensional structure of the MqsR:MqsA complex: a novel TA pair comprised of a toxin homologous to RelE and an antitoxin with unique properties. Plos Pathog., 5, 2009
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6OBS
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![BU of 6obs by Molmil](/molmil-images/mine/6obs) | PP1 Y134K | Descriptor: | GLYCEROL, MANGANESE (II) ION, PHOSPHATE ION, ... | Authors: | Choy, M.S, Moon, T.M, Bray, J.A, Archuleta, T.L, Shi, W, Peti, W, Page, R. | Deposit date: | 2019-03-21 | Release date: | 2019-09-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.803 Å) | Cite: | SDS22 selectively recognizes and traps metal-deficient inactive PP1. Proc.Natl.Acad.Sci.USA, 116, 2019
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8SW5
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![BU of 8sw5 by Molmil](/molmil-images/mine/8sw5) | |