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PDB: 89 件
3VCL
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BU of 3vcl by Molmil
Crystal Structure of HLA-B7 with the HCMV pp65 peptide RPHERNGFTVL
分子名称: Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ...
著者Petersen, J, Rossjohn, J.
登録日2012-01-04
公開日2012-11-21
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The impact of a large and frequent deletion in the human TCR beta locus on antiviral immunity
J.Immunol., 188, 2012
6XP6
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BU of 6xp6 by Molmil
3C11-DQ2-glia-a2 complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3.C11 IgH Fab, ...
著者Petersen, J, Rossjohn, J.
登録日2020-07-08
公開日2021-07-28
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A high-affinity human TCR-like antibody detects celiac disease gluten peptide-MHC complexes and inhibits T cell activation.
Sci Immunol, 6, 2021
8QFZ
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BU of 8qfz by Molmil
TSLP-Bicycle complex
分子名称: 1-[3,5-bis(3-bromanylpropanoyl)-1,3,5-triazinan-1-yl]-3-bromanyl-propan-1-one, CYS-HIS-TRP-LEU-GLU-ASN-CYS-TRP-ARG-GLY-PHE-CYS, Thymic stromal lymphopoietin
著者Petersen, J.
登録日2023-09-05
公開日2024-02-07
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Discovery and Characterization of a Bicyclic Peptide (Bicycle) Binder to Thymic Stromal Lymphopoietin.
J.Med.Chem., 67, 2024
7QB1
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BU of 7qb1 by Molmil
PPARg in complex with inhibitor
分子名称: 3-[(3,4-dichlorophenyl)methyl]-4-oxidanylidene-6-phenoxy-phthalazine-1-carboxylic acid, Peroxisome proliferator-activated receptor gamma, SULFATE ION
著者Petersen, J.
登録日2021-11-17
公開日2022-05-04
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery by Virtual Screening of an Inhibitor of CDK5-Mediated PPAR gamma Phosphorylation.
Acs Med.Chem.Lett., 13, 2022
5NCZ
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BU of 5ncz by Molmil
mPI3Kd IN COMPLEX WITH inh1
分子名称: 1,2-ETHANEDIOL, 4-azanyl-6-[[(1~{S})-1-[6-[3-[(dimethylamino)methyl]phenyl]-3-methyl-5-oxidanylidene-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者Petersen, J.
登録日2017-03-06
公開日2017-06-21
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Design and Synthesis of Soluble and Cell-Permeable PI3K delta Inhibitors for Long-Acting Inhaled Administration.
J. Med. Chem., 60, 2017
5NCY
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BU of 5ncy by Molmil
mPI3Kd IN COMPLEX WITH inh1
分子名称: 1,2-ETHANEDIOL, 4-azanyl-6-[[(1~{S})-1-(3-methyl-5-oxidanylidene-6-phenyl-[1,3]thiazolo[3,2-a]pyridin-7-yl)ethyl]amino]pyrimidine-5-carbonitrile, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, ...
著者Petersen, J.
登録日2017-03-06
公開日2017-06-21
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Design and Synthesis of Soluble and Cell-Permeable PI3K delta Inhibitors for Long-Acting Inhaled Administration.
J. Med. Chem., 60, 2017
7OIL
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BU of 7oil by Molmil
mPI3Kd in complex with compound 58
分子名称: 2-[(1S)-1-cyclopropylethyl]-5-[4-methyl-2-[[6-(2-oxidanylidenepyrrolidin-1-yl)pyridin-2-yl]amino]-1,3-thiazol-5-yl]-7-methylsulfonyl-3H-isoindol-1-one, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, SODIUM ION
著者Petersen, J.
登録日2021-05-11
公開日2021-07-14
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Discovery of AZD8154, a Dual PI3K gamma delta Inhibitor for the Treatment of Asthma.
J.Med.Chem., 64, 2021
7OI4
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mPI3Kd in complex with compound 12
分子名称: N-[5-[2-[(1S)-1-cyclopropylethyl]-7-[[4-[(dimethylamino)methyl]phenyl]sulfamoyl]-1-oxidanylidene-3H-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]ethanamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者Petersen, J.
登録日2021-05-11
公開日2021-07-14
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery of AZD8154, a Dual PI3K gamma delta Inhibitor for the Treatment of Asthma.
J.Med.Chem., 64, 2021
7OIS
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BU of 7ois by Molmil
mPI3Kd in complex with compound 7
分子名称: N-[5-[2-[(1S)-1-cyclopropylethyl]-7-[(3-methylsulfonylphenyl)sulfamoyl]-1-oxidanylidene-3H-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]ethanamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, SODIUM ION
著者Petersen, J.
登録日2021-05-12
公開日2021-07-14
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of AZD8154, a Dual PI3K gamma delta Inhibitor for the Treatment of Asthma.
J.Med.Chem., 64, 2021
7OIJ
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BU of 7oij by Molmil
mPI3Kd in complex with an inhibitor
分子名称: 6-[[5-[2-[(1S)-1-cyclopropylethyl]-7-(methylsulfamoyl)-1-oxidanylidene-3H-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]amino]-N-[3-(dimethylamino)propyl]pyridine-2-carboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, SODIUM ION, ...
著者Petersen, J.
登録日2021-05-11
公開日2021-07-14
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery of AZD8154, a Dual PI3K gamma delta Inhibitor for the Treatment of Asthma.
J.Med.Chem., 64, 2021
4Z7U
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BU of 4z7u by Molmil
S13 complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DQ-alpha chain, MHC class II HLA-DQ-beta-1, ...
著者Petersen, J, Rossjohn, J, Reid, H.H, Koning, F.
登録日2015-04-08
公開日2015-06-03
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Determinants of Gliadin-Specific T Cell Selection in Celiac Disease.
J Immunol., 194, 2015
4Z7W
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T316 complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DQ8-glia-alpha1, MHC class II HLA-DQ-alpha chain, ...
著者Petersen, J, Rossjohn, J, Reid, H.H, Koning, F.
登録日2015-04-08
公開日2015-06-03
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Determinants of Gliadin-Specific T Cell Selection in Celiac Disease.
J Immunol., 194, 2015
4Z7V
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BU of 4z7v by Molmil
L3-12 complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DQ-alpha chain, MHC class II HLA-DQ-beta-1, ...
著者Petersen, J, Rossjohn, J, Reid, H.H, Koning, F.
登録日2015-04-08
公開日2015-06-03
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Determinants of Gliadin-Specific T Cell Selection in Celiac Disease.
J Immunol., 194, 2015
6MFF
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BU of 6mff by Molmil
HLA-DQ2-glia-omega1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, DQ alpha 1 chain, ...
著者Petersen, J, Ciacchi, L, Rossjohn, J.
登録日2018-09-10
公開日2018-11-21
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Discriminative T-cell receptor recognition of highly homologous HLA-DQ2-bound gluten epitopes.
J. Biol. Chem., 294, 2019
6MFG
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BU of 6mfg by Molmil
HLA-DQ2-glia-alpha1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, DQ alpha 1 chain, ...
著者Petersen, J, Ciacchi, L, Rossjohn, J.
登録日2018-09-10
公開日2018-11-21
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discriminative T-cell receptor recognition of highly homologous HLA-DQ2-bound gluten epitopes.
J. Biol. Chem., 294, 2019
1H3J
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BU of 1h3j by Molmil
STRUCTURE OF RECOMBINANT COPRINUS CINEREUS PEROXIDASE DETERMINED TO 2.0 A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, MAGNESIUM ION, ...
著者Petersen, J.F.W, Houborg, K, Harris, P, Larsen, S.
登録日2002-09-05
公開日2003-06-12
最終更新日2023-02-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Impact of the Physical and Chemical Environment on the Molecular Structure of Coprinus Cinereus Peroxidase
Acta Crystallogr.,Sect.D, 59, 2003
5KSB
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BU of 5ksb by Molmil
T15-DQ8.5-glia-gamma1 complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DQ8.5-glia-gamma1 peptide, ...
著者Petersen, J, Rossjohn, J, Reid, H.H.
登録日2016-07-08
公開日2016-09-21
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Diverse T Cell Receptor Gene Usage in HLA-DQ8-Associated Celiac Disease Converges into a Consensus Binding Solution.
Structure, 24, 2016
5KS9
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BU of 5ks9 by Molmil
Bel502-DQ8-glia-alpha1 complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Bel502 TCR alpha TRAV20*01, Bel502 TCR beta TRBV9*01, ...
著者Petersen, J, Rossjohn, J, Reid, H.H.
登録日2016-07-08
公開日2016-09-21
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Diverse T Cell Receptor Gene Usage in HLA-DQ8-Associated Celiac Disease Converges into a Consensus Binding Solution.
Structure, 24, 2016
6U3O
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BU of 6u3o by Molmil
JR51 DQ2-p.aeru-alpha2a complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DQ-alpha chain, MHC class II HLA-DQ-beta-1, ...
著者Petersen, J, Rossjohn, J.
登録日2019-08-22
公開日2019-12-18
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.743 Å)
主引用文献T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease.
Nat.Struct.Mol.Biol., 27, 2020
6U3N
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LS2.8/3.15 - DQ2-P.fluor-alpha1a complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DQ-alpha chain, MHC class II HLA-DQ-beta-1, ...
著者Petersen, J, Rossjohn, J.
登録日2019-08-22
公開日2019-12-18
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease.
Nat.Struct.Mol.Biol., 27, 2020
5KSA
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BU of 5ksa by Molmil
Bel602-DQ8.5-glia-gamma1 complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Bel602 alpha TRAV20*01, Bel602 beta TRBV9*01, ...
著者Petersen, J, Rossjohn, J, Reid, H.H.
登録日2016-07-08
公開日2016-09-21
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Diverse T Cell Receptor Gene Usage in HLA-DQ8-Associated Celiac Disease Converges into a Consensus Binding Solution.
Structure, 24, 2016
6U3M
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DQ2-P.fluor-alpha1a
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha1a peptide, ...
著者Petersen, J, Rossjohn, J.
登録日2019-08-22
公開日2019-12-18
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease.
Nat.Struct.Mol.Biol., 27, 2020
2HRV
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BU of 2hrv by Molmil
2A CYSTEINE PROTEINASE FROM HUMAN RHINOVIRUS 2
分子名称: 2A CYSTEINE PROTEINASE, ZINC ION
著者Petersen, J.F.W, Cherney, M.M, Liebig, H.-D, Skern, T, Kuechler, E, James, M.N.G.
登録日1999-04-29
公開日2000-05-03
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis.
EMBO J., 18, 1999
5V4M
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BU of 5v4m by Molmil
Structure of HLA-DR15 with bound alpha3(135-145) peptide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HLA-DRA1, ...
著者Petersen, J, Rossjohn, J.
登録日2017-03-10
公開日2017-05-03
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.
Nature, 545, 2017
5V4N
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Structure of HLA-DR1 with bound alpha3(135-145) peptide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA-DRA1, alpha3(135-145)-HLA-DRB1*01:01
著者Petersen, J, Rossjohn, J.
登録日2017-03-10
公開日2017-05-03
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.405 Å)
主引用文献Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.
Nature, 545, 2017

 

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