8QFZ

TSLP-Bicycle complex

Summary for 8QFZ

Entry DOI	10.2210/pdb8qfz/pdb
Descriptor	Thymic stromal lymphopoietin, CYS-HIS-TRP-LEU-GLU-ASN-CYS-TRP-ARG-GLY-PHE-CYS, 1-[3,5-bis(3-bromanylpropanoyl)-1,3,5-triazinan-1-yl]-3-bromanyl-propan-1-one, ... (4 entities in total)
Functional Keywords	inhibitor, complex, hormone
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	16631.69
Authors	Petersen, J. (deposition date: 2023-09-05, release date: 2024-02-07, Last modification date: 2024-02-21)
Primary citation	Narjes, F.,Edfeldt, F.,Petersen, J.,Oster, L.,Hamblet, C.,Bird, J.,Bold, P.,Rae, R.,Back, E.,Stomilovic, S.,Zlatoidsky, P.,Svensson, T.,Hidestal, L.,Kunalingam, L.,Shamovsky, I.,De Maria, L.,Gordon, E.,Lewis, R.J.,Watcham, S.,van Rietschoten, K.,Mudd, G.E.,Harrison, H.,Chen, L.,Skynner, M.J. Discovery and Characterization of a Bicyclic Peptide (Bicycle) Binder to Thymic Stromal Lymphopoietin. J.Med.Chem., 67:2220-2235, 2024 Cited by PubMed: 38284169 DOI: 10.1021/acs.jmedchem.3c02163 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation