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PDB: 54 件
1IK9
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BU of 1ik9 by Molmil
CRYSTAL STRUCTURE OF A XRCC4-DNA LIGASE IV COMPLEX
分子名称: DNA LIGASE IV, DNA REPAIR PROTEIN XRCC4
著者Sibanda, B.L, Critchlow, S.E, Begun, J, Pei, X.Y, Jackson, S.P, Blundell, T.L, Pellegrini, L.
登録日2001-05-03
公開日2001-11-21
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of an Xrcc4-DNA ligase IV complex.
Nat.Struct.Biol., 8, 2001
8QJ7
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BU of 8qj7 by Molmil
Cryo-EM structure of human DNA polymerase alpha-primase in pre-initiation stage 1
分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, ...
著者Yin, Z, Pellegrini, L.
登録日2023-09-12
公開日2024-02-21
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.07 Å)
主引用文献CryoEM insights into RNA primer synthesis by the human primosome.
Febs J., 291, 2024
5DGO
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BU of 5dgo by Molmil
Crystal structure of cell division cycle protein 45 (Cdc45)
分子名称: 1,2-ETHANEDIOL, Cell division control protein 45 homolog, SULFATE ION
著者Simon, A.C, Pellegrini, L.
登録日2015-08-28
公開日2016-05-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of human Cdc45 and implications for CMG helicase function.
Nat Commun, 7, 2016
6XTX
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BU of 6xtx by Molmil
CryoEM structure of human CMG bound to ATPgammaS and DNA
分子名称: ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45 homolog, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), ...
著者Rzechorzek, N.J, Pellegrini, L.
登録日2020-01-16
公開日2020-05-27
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.29 Å)
主引用文献CryoEM structures of human CMG-ATP gamma S-DNA and CMG-AND-1 complexes.
Nucleic Acids Res., 48, 2020
6XTY
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BU of 6xty by Molmil
CryoEM structure of human CMG bound to AND-1 (CMGA)
分子名称: Cell division control protein 45 homolog, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ...
著者Rzechorzek, N.J, Pellegrini, L, Chirgadze, D.Y, Hardwick, S.W.
登録日2020-01-16
公開日2020-05-27
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (6.77 Å)
主引用文献CryoEM structures of human CMG-ATP gamma S-DNA and CMG-AND-1 complexes.
Nucleic Acids Res., 48, 2020
6TAZ
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BU of 6taz by Molmil
Timeless couples G quadruplex detection with processing by DDX11 during DNA replication
分子名称: Protein timeless homolog
著者Lerner Koch, L, Holzer, S, Kilkenny, M.L, Murat, P, Svikovic, S, Schiavone, D, Bittleston, A, Maman, J.D, Branzei, D, Stott, K, Pellegrini, L, Sale, E.J.
登録日2019-10-31
公開日2020-07-01
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication.
Embo J., 39, 2020
6R4S
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BU of 6r4s by Molmil
Crystal structure of the Pri1 subunit of human primase bound to ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA primase small subunit, MANGANESE (II) ION, ...
著者Kilkenny, M.L, Pellegrini, L.
登録日2019-03-24
公開日2019-09-11
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
6R4T
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BU of 6r4t by Molmil
Crystal structure of the Pri1 subunit of human primase bound to vidarabine triphosphate
分子名称: 1,2-ETHANEDIOL, 9-{5-O-[(S)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}-9H-purin-6-amine, DNA primase small subunit, ...
著者Kilkenny, M.L, Pellegrini, L.
登録日2019-03-24
公開日2019-09-11
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
6RB4
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BU of 6rb4 by Molmil
Crystal structure of the Pri1 subunit of human primase
分子名称: 1,2-ETHANEDIOL, DNA primase small subunit, ZINC ION
著者Kilkenny, M.L, Pellegrini, L.
登録日2019-04-09
公開日2019-09-11
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
6R5E
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BU of 6r5e by Molmil
Crystal structure of the Pri1 subunit of human primase bound to 2F-ATP
分子名称: 1,2-ETHANEDIOL, 2-fluoro-ATP, DNA primase small subunit, ...
著者Kilkenny, M.L, Pellegrini, L.
登録日2019-03-24
公開日2019-09-11
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
6R5D
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BU of 6r5d by Molmil
Crystal structure of the Pri1 subunit of human primase bound to dATP
分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA primase small subunit, ...
著者Kilkenny, M.L, Pellegrini, L.
登録日2019-03-24
公開日2019-09-11
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
6R4U
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BU of 6r4u by Molmil
Crystal structure of the Pri1 subunit of human primase bound to fludarabine triphosphate
分子名称: 1,2-ETHANEDIOL, 2-fluoro-9-{5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}-9H-purin-6-a mine, DNA primase small subunit, ...
著者Kilkenny, M.L, Pellegrini, L.
登録日2019-03-24
公開日2019-09-11
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
4FXD
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BU of 4fxd by Molmil
Crystal structure of yeast DNA polymerase alpha bound to DNA/RNA
分子名称: DNA (5'-D(*TP*TP*TP*TP*CP*GP*CP*TP*GP*CP*CP*CP*GP*CP*CP*T)-3'), DNA polymerase alpha catalytic subunit A, RNA (5'-R(*AP*GP*GP*CP*GP*GP*GP*CP*AP*G)-3')
著者Perera, R.L, Torella, R, Klinge, S, Kilkenny, M.L, Maman, J.D, Pellegrini, L.
登録日2012-07-03
公開日2013-02-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Mechanism for priming DNA synthesis by yeast DNA Polymerase alpha
eLife, 2, 2013
3C1D
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BU of 3c1d by Molmil
X-ray crystal structure of RecX
分子名称: Regulatory protein recX
著者Ragone, S, Maman, J.D, Furnham, N, Pellegrini, L.
登録日2008-01-23
公開日2008-07-15
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for inhibition of homologous recombination by the RecX protein.
Embo J., 27, 2008
3FLO
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BU of 3flo by Molmil
Crystal structure of the carboxyl-terminal domain of yeast DNA polymerase alpha in complex with its B subunit
分子名称: DNA polymerase alpha catalytic subunit A, DNA polymerase alpha subunit B, SULFATE ION, ...
著者Klinge, S.N, Pellegrini, L.
登録日2008-12-19
公開日2009-06-09
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献3D architecture of DNA Pol alpha reveals the functional core of multi-subunit replicative polymerases
Embo J., 28, 2009
5MQI
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BU of 5mqi by Molmil
Crystal structure of the N-terminal domain of human Timeless
分子名称: Protein timeless homolog,Protein timeless homolog, SULFATE ION
著者Holzer, S, Kilkenny, M.L, Pellegrini, L.
登録日2016-12-20
公開日2017-03-08
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.847 Å)
主引用文献Crystal structure of the N-terminal domain of human Timeless and its interaction with Tipin.
Nucleic Acids Res., 45, 2017
4C8H
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BU of 4c8h by Molmil
Crystal structure of the C-terminal region of yeast Ctf4, selenomethionine protein.
分子名称: CTF4
著者Simon, A.C, Pellegrini, L.
登録日2013-10-01
公開日2014-04-30
最終更新日2014-06-18
実験手法X-RAY DIFFRACTION (2.691 Å)
主引用文献A Ctf4 Trimer Couples the Cmg Helicase to DNA Polymerase Alpha in the Eukaryotic Replisome
Nature, 510, 2014
4C8S
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BU of 4c8s by Molmil
Crystal structure of the C-terminal region of yeast Ctf4
分子名称: DNA POLYMERASE ALPHA-BINDING PROTEIN
著者Simon, A.C, Pellegrini, L.
登録日2013-10-01
公開日2014-04-30
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献A Ctf4 Trimer Couples the Cmg Helicase to DNA Polymerase a in the Eukaryotic Replisome
Nature, 510, 2014
4C95
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Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to Sld5
分子名称: DNA POLYMERASE ALPHA-BINDING PROTEIN, DNA REPLICATION COMPLEX GINS PROTEIN SLD5
著者Simon, A.C, Pellegrini, L.
登録日2013-10-02
公開日2014-04-30
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.694 Å)
主引用文献A Ctf4 Trimer Couples the Cmg Helicase to DNA Polymerase a in the Eukaryotic Replisome
Nature, 510, 2014
4C93
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BU of 4c93 by Molmil
Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to Pol alpha.
分子名称: DNA POLYMERASE ALPHA CATALYTIC SUBUNIT A, DNA POLYMERASE ALPHA-BINDING PROTEIN
著者Simon, A.C, Pellegrini, L.
登録日2013-10-02
公開日2014-04-30
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.694 Å)
主引用文献A Ctf4 Trimer Couples the Cmg Helicase to DNA Polymerase a in the Eukaryotic Replisome
Nature, 510, 2014
4B08
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BU of 4b08 by Molmil
Yeast DNA polymerase alpha, Selenomethionine protein
分子名称: DNA POLYMERASE ALPHA CATALYTIC SUBUNIT A
著者Perera, R.L, Torella, R, Klinge, S, Kilkenny, M.L, Maman, J.D, Pellegrini, L.
登録日2012-06-29
公開日2013-02-27
最終更新日2013-05-01
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Mechanism for Priming DNA Synthesis by Yeast DNA Polymerase Alpha
Elife, 2, 2013
4BPW
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BU of 4bpw by Molmil
Crystal structure of human primase bound to UTP
分子名称: DNA PRIMASE LARGE SUBUNIT, DNA PRIMASE SMALL SUBUNIT, MAGNESIUM ION, ...
著者Kilkenny, M.L, Perera, R.L, Pellegrini, L.
登録日2013-05-28
公開日2013-09-25
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.003 Å)
主引用文献Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering
Proc.Natl.Acad.Sci.USA, 110, 2013
4BPU
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BU of 4bpu by Molmil
Crystal structure of human primase in heterodimeric form, comprising PriS and truncated PriL lacking the C-terminal Fe-S domain.
分子名称: DNA PRIMASE LARGE SUBUNIT, DNA PRIMASE SMALL SUBUNIT, GLYCEROL, ...
著者Kilkenny, M.L, Perera, R.L, Pellegrini, L.
登録日2013-05-28
公開日2013-09-25
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering
Proc.Natl.Acad.Sci.USA, 110, 2013
4BPX
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BU of 4bpx by Molmil
Crystal structure of human primase in complex with the primase- binding motif of DNA polymerase alpha
分子名称: DNA POLYMERASE ALPHA CATALYTIC SUBUNIT, DNA PRIMASE LARGE SUBUNIT, DNA PRIMASE SMALL SUBUNIT, ...
著者Kilkenny, M.L, Perera, R.L, Pellegrini, L.
登録日2013-05-28
公開日2013-09-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering
Proc.Natl.Acad.Sci.USA, 110, 2013
4CPC
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BU of 4cpc by Molmil
Crystal structure of human synaptonemal complex protein SYCP3
分子名称: SYNAPTONEMAL COMPLEX PROTEIN 3
著者Syrjanen, J.L, Pellegrini, L, Davies, O.R.
登録日2014-02-05
公開日2014-07-02
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献A molecular model for the role of SYCP3 in meiotic chromosome organisation.
Elife, 3, 2014

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