4CPC
Crystal structure of human synaptonemal complex protein SYCP3
Summary for 4CPC
| Entry DOI | 10.2210/pdb4cpc/pdb |
| Descriptor | SYNAPTONEMAL COMPLEX PROTEIN 3 (2 entities in total) |
| Functional Keywords | cell cycle, meiosis, homologous recombination, chromosome structure, coiled-coil, four- helix bundle |
| Biological source | HOMO SAPIENS (HUMAN) |
| Total number of polymer chains | 8 |
| Total formula weight | 159191.03 |
| Authors | Syrjanen, J.L.,Pellegrini, L.,Davies, O.R. (deposition date: 2014-02-05, release date: 2014-07-02, Last modification date: 2024-05-01) |
| Primary citation | Syrjanen, J.L.,Pellegrini, L.,Davies, O.R. A molecular model for the role of SYCP3 in meiotic chromosome organisation. Elife, 3:-, 2014 Cited by PubMed Abstract: The synaptonemal complex (SC) is an evolutionarily-conserved protein assembly that holds together homologous chromosomes during prophase of the first meiotic division. Whilst essential for meiosis and fertility, the molecular structure of the SC has proved resistant to elucidation. The SC protein SYCP3 has a crucial but poorly understood role in establishing the architecture of the meiotic chromosome. Here we show that human SYCP3 forms a highly-elongated helical tetramer of 20 nm length. N-terminal sequences extending from each end of the rod-like structure bind double-stranded DNA, enabling SYCP3 to link distant sites along the sister chromatid. We further find that SYCP3 self-assembles into regular filamentous structures that resemble the known morphology of the SC lateral element. Together, our data form the basis for a model in which SYCP3 binding and assembly on meiotic chromosomes leads to their organisation into compact structures compatible with recombination and crossover formation. PubMed: 24950965DOI: 10.7554/eLife.02963 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.24 Å) |
Structure validation
Download full validation report
