7S6M
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7S81
| Structure of human PARP1 domains (Zn1, Zn3, WGR, HD) bound to a DNA double strand break. | 分子名称: | DNA (5'-D(*AP*TP*GP*CP*GP*GP*CP*CP*GP*CP*AP*T)-3'), Poly [ADP-ribose] polymerase 1, ZINC ION | 著者 | Rouleau-Turcotte, E, Pascal, J.M. | 登録日 | 2021-09-17 | 公開日 | 2022-06-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery. Mol.Cell, 82, 2022
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8FYZ
| Crystal structure of human PARP1 ART domain bound to inhibitor UKTT10 (compound 13) | 分子名称: | (2P)-2-{3-[(4R)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carbonyl]phenyl}-1H-benzimidazole-4-carboxamide, CITRIC ACID, DIMETHYL SULFOXIDE, ... | 著者 | Rouleau-Turcotte, E, Pascal, J.M. | 登録日 | 2023-01-27 | 公開日 | 2024-02-07 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks. Biochem.J., 481, 2024
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8FYY
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8G0H
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8FZ1
| Crystal structure of human PARP1 ART domain bound to inhibitor UKTT22 (compound 14) | 分子名称: | (2P)-2-{3-[(2-amino-4,5-dimethylphenyl)carbamoyl]phenyl}-1H-benzimidazole-4-carboxamide, 1,2-ETHANEDIOL, CITRIC ACID, ... | 著者 | Rouleau-Turcotte, E, Pascal, J.M. | 登録日 | 2023-01-27 | 公開日 | 2024-02-07 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks. Biochem.J., 481, 2024
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4DQY
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5DS3
| Crystal structure of constitutively active PARP-1 | 分子名称: | 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one, PENTAETHYLENE GLYCOL, Poly [ADP-ribose] polymerase 1, ... | 著者 | Langelier, M.F, Pascal, J.M. | 登録日 | 2015-09-16 | 公開日 | 2016-07-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain. Mol.Cell, 60, 2015
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5DSY
| Crystal structure of constitutively active PARP-2 | 分子名称: | 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide, Poly [ADP-ribose] polymerase 2 | 著者 | Riccio, A.A, Pascal, J.M. | 登録日 | 2015-09-17 | 公開日 | 2016-07-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain. Mol.Cell, 60, 2015
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4G28
| Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and EBIO-1 | 分子名称: | 1-ethyl-1,3-dihydro-2H-benzimidazol-2-one, CALCIUM ION, Calmodulin, ... | 著者 | Zhang, M, Pascal, J.M, Zhang, J.-F. | 登録日 | 2012-07-11 | 公開日 | 2012-09-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Identification of the functional binding pocket for compounds targeting small-conductance Ca(2+)-activated potassium channels. Nat Commun, 3, 2012
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4G27
| Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and phenylurea | 分子名称: | 1-phenylurea, CALCIUM ION, Calmodulin, ... | 著者 | Zhang, M, Pascal, J.M, Zhang, J.-F. | 登録日 | 2012-07-11 | 公開日 | 2012-09-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Identification of the functional binding pocket for compounds targeting small-conductance Ca(2+)-activated potassium channels. Nat Commun, 3, 2012
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4J9Y
| Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant | 分子名称: | CALCIUM ION, Calmodulin, GLYCEROL, ... | 著者 | Zhang, M, Pascal, J.M, Zhang, J.-F. | 登録日 | 2013-02-17 | 公開日 | 2013-03-27 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation. Proc.Natl.Acad.Sci.USA, 110, 2013
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4J9Z
| Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and NS309 | 分子名称: | (3E)-6,7-dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one, CALCIUM ION, Calmodulin, ... | 著者 | Zhang, M, Pascal, J.M, Zhang, J.-F. | 登録日 | 2013-02-17 | 公開日 | 2013-03-27 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation. Proc.Natl.Acad.Sci.USA, 110, 2013
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8SWY
| PARP4 ART domain bound to NADH | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLYCEROL, Protein mono-ADP-ribosyltransferase PARP4 | 著者 | Frigon, L, Pascal, J.M. | 登録日 | 2023-05-19 | 公開日 | 2023-11-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP. Nucleic Acids Res., 51, 2023
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8SX2
| PARP4 catalytic domain bound to EB47 | 分子名称: | 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide, Protein mono-ADP-ribosyltransferase PARP4 | 著者 | Frigon, L, Pascal, J.M. | 登録日 | 2023-05-19 | 公開日 | 2023-11-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP. Nucleic Acids Res., 51, 2023
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8SX1
| PARP4 catalytic domain | 分子名称: | Protein mono-ADP-ribosyltransferase PARP4 | 著者 | Frigon, L, Pascal, J.M. | 登録日 | 2023-05-19 | 公開日 | 2023-11-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | 主引用文献 | Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP. Nucleic Acids Res., 51, 2023
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8SWZ
| PARP4 ART domain bound to EB47 | 分子名称: | 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide, GLYCEROL, Protein mono-ADP-ribosyltransferase PARP4 | 著者 | Frigon, L, Pascal, J.M. | 登録日 | 2023-05-19 | 公開日 | 2023-11-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP. Nucleic Acids Res., 51, 2023
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3SJQ
| Crystal structure of a small conductance potassium channel splice variant complexed with calcium-calmodulin | 分子名称: | 1-phenylurea, CALCIUM ION, Calmodulin, ... | 著者 | Zhang, M, Pascal, J.M, Zhang, J.-F. | 登録日 | 2011-06-21 | 公開日 | 2012-05-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis for calmodulin as a dynamic calcium sensor. Structure, 20, 2012
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5D5K
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4QNH
| Calcium-calmodulin (T79D) complexed with the calmodulin binding domain from a small conductance potassium channel SK2-a | 分子名称: | CALCIUM ION, Calmodulin, SULFATE ION, ... | 著者 | Zhang, M, Pascal, J.M, Logothetis, D.E, Zhang, J.F. | 登録日 | 2014-06-17 | 公開日 | 2014-08-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex. Nat.Chem.Biol., 10, 2014
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6NRJ
| Crystal Structure of human PARP-1 ART domain bound to inhibitor UTT93 | 分子名称: | (2Z)-2-[(4-{[2-(1H-benzimidazol-2-yl)ethyl]carbamoyl}phenyl)methylidene]-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide, DIMETHYL SULFOXIDE, Poly [ADP-ribose] polymerase 1, ... | 著者 | Langelier, M.F, Pascal, J.M. | 登録日 | 2019-01-23 | 公開日 | 2019-08-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity. J.Med.Chem., 62, 2019
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6NTU
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6NRG
| Crystal Structure of human PARP-1 ART domain bound to inhibitor UTT57 | 分子名称: | 2-{[3-fluoro-4-(1H-tetrazol-5-yl)phenyl]methyl}-3-hydroxy-1-benzofuran-7-carboxamide, DIMETHYL SULFOXIDE, Poly [ADP-ribose] polymerase 1, ... | 著者 | Langelier, M.F, Pascal, J.M. | 登録日 | 2019-01-23 | 公開日 | 2019-08-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity. J.Med.Chem., 62, 2019
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6NRI
| Crystal Structure of human PARP-1 ART domain bound to inhibitor UTT83 | 分子名称: | (2Z)-2-{[4-(3-cyclopropyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carbonyl)phenyl]methylidene}-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide, CHLORIDE ION, CITRIC ACID, ... | 著者 | Langelier, M.F, Pascal, J.M. | 登録日 | 2019-01-23 | 公開日 | 2019-08-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity. J.Med.Chem., 62, 2019
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6NRF
| Crystal Structure of human PARP-1 ART domain bound to inhibitor UTT103 | 分子名称: | 2-({4-[4-(1H-benzimidazol-2-yl)piperazine-1-carbonyl]phenyl}methyl)-3-hydroxy-1-benzofuran-7-carboxamide, CHLORIDE ION, CITRIC ACID, ... | 著者 | Langelier, M.F, Pascal, J.M. | 登録日 | 2019-01-23 | 公開日 | 2019-08-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity. J.Med.Chem., 62, 2019
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