4DQY
Structure of Human PARP-1 bound to a DNA double strand break
Summary for 4DQY
Entry DOI | 10.2210/pdb4dqy/pdb |
Descriptor | Poly [ADP-ribose] polymerase 1, DNA (26-MER), ZINC ION, ... (6 entities in total) |
Functional Keywords | parp, poly(adp-ribose) polymerase, dna binding protein, adp-ribosyl transferase, parp-like zinc finger, poly(adp-ribosyl)ation, dna damage detection, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P09874 P09874 P09874 |
Total number of polymer chains | 8 |
Total formula weight | 193570.52 |
Authors | Langelier, M.F.,Pascal, J.M. (deposition date: 2012-02-16, release date: 2012-05-30, Last modification date: 2024-02-28) |
Primary citation | Langelier, M.F.,Planck, J.L.,Roy, S.,Pascal, J.M. Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1. Science, 336:728-732, 2012 Cited by PubMed: 22582261DOI: 10.1126/science.1216338 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.25 Å) |
Structure validation
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