4DQY
Structure of Human PARP-1 bound to a DNA double strand break
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Poly [ADP-ribose] polymerase 1 | polymer | 116 | 13101.8 | 2 | UniProt (P09874) Pfam (PF00645) | Homo sapiens (human) | |
| 2 | B, E (B, E) | Poly [ADP-ribose] polymerase 1 | polymer | 160 | 18393.3 | 2 | UniProt (P09874) Pfam (PF21728) Pfam (PF08063) | Homo sapiens (human) | |
| 3 | C, F (C, F) | Poly [ADP-ribose] polymerase 1 | polymer | 506 | 57138.2 | 2 | UniProt (P09874) Pfam (PF05406) Pfam (PF02877) Pfam (PF00644) | Homo sapiens (human) | PARP-1, NAD(+) ADP-ribosyltransferase 1, ADPRT 1, Poly[ADP-ribose] synthase 1 |
| 4 | G, H (M, N) | DNA (26-MER) | polymer | 26 | 7990.1 | 2 | |||
| 5 | I, J, L, M (A, B, D, E) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 6 | K (C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) |
Sequence modifications
A, D: 1 - 96 (UniProt: P09874)
B, E: 216 - 366 (UniProt: P09874)
C, F: 518 - 1014 (UniProt: P09874)
| PDB | External Database | Details |
|---|---|---|
| Met -19 | - | expression tag |
| Gly -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Ser -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 215 | - | initiating methionine |
| Leu 367 | - | expression tag |
| Glu 368 | - | expression tag |
| His 369 | - | expression tag |
| His 370 | - | expression tag |
| His 371 | - | expression tag |
| His 372 | - | expression tag |
| His 373 | - | expression tag |
| His 374 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 517 | - | initiating methionine |
| Ala 762 | Val 762 | SEE REMARK 999 |
| Leu 1015 | - | expression tag |
| Glu 1016 | - | expression tag |
| His 1017 | - | expression tag |
| His 1018 | - | expression tag |
| His 1019 | - | expression tag |
| His 1020 | - | expression tag |
| His 1021 | - | expression tag |
| His 1022 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 193246.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 323.7 | |
| All* | Total formula weight | 193570.5 |
