8G0H

Human PARP1 deltaV687-E688 bound to UKTT5 (compound 10) and to a DNA double strand break.

Summary for 8G0H

• Entry DOI: 10.2210/pdb8g0h/pdb
• Related: 8FYY 8FYZ 8FZ1
• Descriptor: DNA (5'-D(*CP*GP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*CP*G)-3'), Poly [ADP-ribose] polymerase 1, ... (6 entities in total)
• Functional Keywords: parp, adp-ribose transferase, dna break detection, zinc finger, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 183458.13

Authors

Rouleau-Turcotte, E.,Pascal, J.M. (deposition date: 2023-01-31, release date: 2024-02-07, Last modification date: 2024-03-27)

• Primary citation: Velagapudi, U.K.,Rouleau-Turcotte, E.,Billur, R.,Shao, X.,Patil, M.,Black, B.E.,Pascal, J.M.,Talele, T.T.; Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks.; Biochem.J., 481:437-460, 2024; PubMed: 38372302; DOI: 10.1042/BCJ20230406

Experimental method

X-RAY DIFFRACTION (3.8 Å)