8FYZ
Crystal structure of human PARP1 ART domain bound to inhibitor UKTT10 (compound 13)
Summary for 8FYZ
| Entry DOI | 10.2210/pdb8fyz/pdb |
| Related | 8FYY 8FZ1 8G0H |
| Descriptor | Poly [ADP-ribose] polymerase 1, processed C-terminus, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, DIMETHYL SULFOXIDE, ... (6 entities in total) |
| Functional Keywords | parp, adp-ribosyltransferase, dna binding protein, dna binding protein-inhibitor complex, dna binding protein/inhibitor |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 61764.29 |
| Authors | Rouleau-Turcotte, E.,Pascal, J.M. (deposition date: 2023-01-27, release date: 2024-02-07, Last modification date: 2024-03-20) |
| Primary citation | Velagapudi, U.K.,Rouleau-Turcotte, E.,Billur, R.,Shao, X.,Patil, M.,Black, B.E.,Pascal, J.M.,Talele, T.T. Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks. Biochem.J., 481:437-460, 2024 Cited by PubMed: 38372302DOI: 10.1042/BCJ20230406 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
Download full validation report
