8FYY

Crystal structure of human PARP1 ART domain bound to inhibitor UKTT5 (compound 10)

Summary for 8FYY

Entry DOI	10.2210/pdb8fyy/pdb
Related	8FYZ 8FZ1 8G0H
Descriptor	Poly [ADP-ribose] polymerase 1, processed C-terminus, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, 2-(4-{[2-(1H-benzimidazol-2-yl)ethyl]carbamoyl}phenyl)-1H-benzimidazole-7-carboxamide, ... (6 entities in total)
Functional Keywords	parp, adp-ribose transferase, dna binding protein, dna binding protein-inhibitor complex, dna binding protein/inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	30954.28
Authors	Rouleau-Turcotte, E.,Pascal, J.M. (deposition date: 2023-01-27, release date: 2024-02-07, Last modification date: 2024-03-20)
Primary citation	Velagapudi, U.K.,Rouleau-Turcotte, E.,Billur, R.,Shao, X.,Patil, M.,Black, B.E.,Pascal, J.M.,Talele, T.T. Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks. Biochem.J., 481:437-460, 2024 Cited by PubMed: 38372302 DOI: 10.1042/BCJ20230406 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation