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8FYY

Crystal structure of human PARP1 ART domain bound to inhibitor UKTT5 (compound 10)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003950molecular_functionNAD+-protein poly-ADP-ribosyltransferase activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: For poly [ADP-ribose] polymerase activity => ECO:0000305|PubMed:32028527, ECO:0000305|PubMed:7852410, ECO:0000305|PubMed:9315851
ChainResidueDetails
AGLU988

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q9UGN5
ChainResidueDetails
AHIS862
AGLY871
AARG878
ASER904

227561

PDB entries from 2024-11-20

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