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PDB: 90 results

3KGF
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The structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis complexed with phenylalanine and tryptophan
Descriptor: CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ...
Authors:Parker, E.J, Jameson, G.B, Jiao, W, Webby, C.J, Baker, E.N, Baker, H.M, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2009-10-29
Release date:2010-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis
J.Biol.Chem., 285, 2010
3NV8
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The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase in complex with phosphoenol pyruvate and manganese (thesit-free)
Descriptor: CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ...
Authors:Parker, E.J, Jameson, G.B, Jiao, W, Hutton, R.H, Webby, C.J, Baker, E.N, Baker, H.M.
Deposit date:2010-07-08
Release date:2010-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis
J.Biol.Chem., 285, 2010
3NUD
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The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from mycobacterium tuberculosis complexed with phenylalanine
Descriptor: PHENYLALANINE, PHOSPHATE ION, Probable 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG
Authors:Parker, E.J, Jameson, G.B, Jiao, W, Webby, C.J, Baker, E.N, Baker, H.M.
Deposit date:2010-07-06
Release date:2010-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis
J.Biol.Chem., 285, 2010
3NUE
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The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from mycobacterium tuberculosis complexed with tryptophan
Descriptor: CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ...
Authors:Parker, E.J, Jameson, G.B, Jiao, W, Webby, C.J, Baker, E.N, Baker, H.M.
Deposit date:2010-07-06
Release date:2010-07-28
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis
J.Biol.Chem., 285, 2010
5J6F
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Crystal structure of DAH7PS-CM complex from Geobacillus sp. with prephenate
Descriptor: 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, chorismate mutase-isozyme 3, MANGANESE (II) ION, ...
Authors:Nazmi, A.R, Othman, M, Lang, E.J.M, Bai, Y, Allison, T.M, Panjkar, S, Arcus, V.L, Parker, E.J.
Deposit date:2016-04-04
Release date:2016-09-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Interdomain Conformational Changes Provide Allosteric Regulation en Route to Chorismate.
J. Biol. Chem., 291, 2016
3STG
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Crystal structure of A58P, DEL(N59), and loop 7 truncated mutant of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis
Descriptor: 2-dehydro-3-deoxyphosphooctonate aldolase, CHLORIDE ION
Authors:Allison, T.M, Jameson, G.B, Parker, E.J.
Deposit date:2011-07-09
Release date:2011-11-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:An Extended (beta)7(alpha)7 Substrate-Binding Loop Is Essential for Efficient Catalysis by 3-Deoxy-D-manno-Octulosonate 8-Phosphate Synthase
Biochemistry, 50, 2011
3STE
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Crystal structure of a mutant (Q202A) of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis
Descriptor: 2-dehydro-3-deoxyphosphooctonate aldolase, CHLORIDE ION, SODIUM ION
Authors:Allison, T.M, Jameson, G.B, Gloyne, B.J, Parker, E.J.
Deposit date:2011-07-09
Release date:2011-11-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:An Extended (beta)7(alpha)7 Substrate-Binding Loop Is Essential for Efficient Catalysis by 3-Deoxy-D-manno-Octulosonate 8-Phosphate Synthase
Biochemistry, 50, 2011
4UC5
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Neisseria Meningitidis DAH7PS-Phenylalanine regulated
Descriptor: DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, PHENYLALANINE, ...
Authors:Heyes, L.C, Lang, E.J.M, Parker, E.J.
Deposit date:2014-12-03
Release date:2015-11-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Calculated Pka Variations Expose Dynamic Allosteric Communication Networks.
J.Am.Chem.Soc., 138, 2016
4N8Q
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Alternative substrates of Mycobacterium tuberculosis anthranilate phosphoribosyl transferase
Descriptor: 2-amino-4-fluorobenzoic acid, Anthranilate phosphoribosyltransferase
Authors:Castell, A, Cookson, T.V.M, Bulloch, E, Evans, G.L, Baker, E.N, Lott, J.S, Parker, E.J.
Deposit date:2013-10-17
Release date:2014-04-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochem.J., 461, 2014
4YB6
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Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni in complex with the inhibitors AMP and histidine
Descriptor: ADENOSINE MONOPHOSPHATE, ATP phosphoribosyltransferase, DI(HYDROXYETHYL)ETHER, ...
Authors:Mittelstaedt, G, Moggre, G.-J, Parker, E.J.
Deposit date:2015-02-18
Release date:2016-03-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Campylobacter jejuni adenosine triphosphate phosphoribosyltransferase is an active hexamer that is allosterically controlled by the twisting of a regulatory tail.
Protein Sci., 25, 2016
4YB5
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Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni in complex with the allosteric inhibitor histidine
Descriptor: ATP phosphoribosyltransferase, DI(HYDROXYETHYL)ETHER, HISTIDINE, ...
Authors:Mittelstaedt, G, Moggre, G.-J, Parker, E.J.
Deposit date:2015-02-18
Release date:2016-03-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Campylobacter jejuni adenosine triphosphate phosphoribosyltransferase is an active hexamer that is allosterically controlled by the twisting of a regulatory tail.
Protein Sci., 25, 2016
4YB7
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BU of 4yb7 by Molmil
Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni in complex with ATP
Descriptor: ACETIC ACID, ADENOSINE-5'-TRIPHOSPHATE, ATP phosphoribosyltransferase, ...
Authors:Mittelstaedt, G, Moggre, G.-J, Parker, E.J.
Deposit date:2015-02-18
Release date:2016-03-09
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Campylobacter jejuni adenosine triphosphate phosphoribosyltransferase is an active hexamer that is allosterically controlled by the twisting of a regulatory tail.
Protein Sci., 25, 2016
6AL9
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BU of 6al9 by Molmil
Crystal structure of chorismate mutase from Helicobacter pylori in complex with prephenate
Descriptor: Chorismate mutase, P-HYDROXYBENZOIC ACID, PREPHENIC ACID, ...
Authors:Fan, Y, Jameson, G.B, Panjikar, S, Parker, E.J.
Deposit date:2017-08-07
Release date:2018-11-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of chorismate mutase from Helicobacter pylori in complex with prephenate
To Be Published
4X58
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Anthranilate phosphoribosyl transferase variant N138A from Mycobacterium tuberculosis in complex with PRPP and Mg
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, D-MALATE, ...
Authors:Cookson, T.V.M, Evans, G.L, Parker, E.J, Lott, J.S.
Deposit date:2014-12-04
Release date:2015-11-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry, 54, 2015
4X59
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BU of 4x59 by Molmil
Anthranilate phosphoribosyltransferase variant P180A from Mycobacterium tuberculosis in complex with PRPP and Mg
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, GLYCEROL, ...
Authors:Cookson, T.V.M, Evans, G.L, Parker, E.J, Lott, J.S.
Deposit date:2014-12-04
Release date:2015-11-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry, 54, 2015
4X5E
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BU of 4x5e by Molmil
Anthranilate phosphoribosyltransferase variant R194A from Mycobacterium tuberculosis with pyrophosphate, Mg2+ and anthranilate bound
Descriptor: 2-AMINOBENZOIC ACID, Anthranilate phosphoribosyltransferase, GLYCEROL, ...
Authors:Cookson, T.V.M, Evans, G.L, Parker, E.J, Lott, J.S.
Deposit date:2014-12-05
Release date:2015-11-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry, 54, 2015
4X5A
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BU of 4x5a by Molmil
Anthranilate phosphoribosyltransferase variant R193A from Mycobacterium tuberculosis remains ligand-free when co-crystallised with PRPP and Mg
Descriptor: Anthranilate phosphoribosyltransferase, GLYCEROL
Authors:Cookson, T.V.M, Parker, E.J, Lott, J.S.
Deposit date:2014-12-05
Release date:2015-11-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry, 54, 2015
4X5C
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BU of 4x5c by Molmil
Anthranilate phosphoribosyltransferase variant R193L from Mycobacterium tuberculosis with pyrophosphate/PRPP and Mg2+ bound
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, MAGNESIUM ION, ...
Authors:Cookson, T.V.M, Parker, E.J, Lott, J.S.
Deposit date:2014-12-05
Release date:2015-11-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry, 54, 2015
4X5D
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BU of 4x5d by Molmil
Anthranilate phosphoribosyltransferase variant R193A from Mycobacterium tuberculosis with anthranilate bound
Descriptor: 2-AMINOBENZOIC ACID, Anthranilate phosphoribosyltransferase, GLYCEROL, ...
Authors:Cookson, T.V.M, Parker, E.J, Lott, J.S.
Deposit date:2014-12-05
Release date:2015-09-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry, 54, 2015
4X5B
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BU of 4x5b by Molmil
Anthranilate phosphoribosyltransferase variant R193L from Mycobacterium tuberculosis in complex with PRPP and Mg
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, MAGNESIUM ION
Authors:Cookson, T.V.M, Parker, E.J, Lott, J.S.
Deposit date:2014-12-05
Release date:2015-11-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry, 54, 2015
1ZCO
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BU of 1zco by Molmil
Crystal structure of pyrococcus furiosus 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
Descriptor: 2-dehydro-3-deoxyphosphoheptonate aldolase, CHLORIDE ION, MANGANESE (II) ION, ...
Authors:Schofield, L.R, Anderson, B.F, Patchett, M.L, Norris, G.E, Jameson, G.B, Parker, E.J.
Deposit date:2005-04-12
Release date:2005-10-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Substrate Ambiguity and Crystal Structure of Pyrococcus furiosus 3-Deoxy-d-arabino-heptulosonate-7-phosphate Synthase: An Ancestral 3-Deoxyald-2-ulosonate-phosphate Synthase?(,)
Biochemistry, 44, 2005
4UMC
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BU of 4umc by Molmil
Structural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase - the importance of accommodating the active site water
Descriptor: L-PHOSPHOLACTATE, MANGANESE (II) ION, PHOSPHATE ION, ...
Authors:Heyes, L.C, Reichau, S, Cross, P.J, Parker, E.J.
Deposit date:2014-05-16
Release date:2014-10-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase - the Importance of Accommodating the Active Site Water.
Bioorg.Chem., 57, 2014
4UMB
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BU of 4umb by Molmil
Structural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase - the importance of accommodating the active site water
Descriptor: (2R)-2-(phosphonooxy)propanoic acid, MANGANESE (II) ION, PHOSPHATE ION, ...
Authors:Heyes, L.C, Reichau, S, Cross, P.J, Parker, E.J.
Deposit date:2014-05-16
Release date:2014-10-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase - the Importance of Accommodating the Active Site Water.
Bioorg.Chem., 57, 2014
4UMA
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Structural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3 deoxy D arabino heptulosonate 7 phosphate synthase the importance of accommodating the active site water
Descriptor: (E)-2-METHYL-3-PHOSPHONOACRYLATE, MANGANESE (II) ION, PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE
Authors:Heyes, L.C, Reichau, S, Cross, P.J, Parker, E.J.
Deposit date:2014-05-16
Release date:2014-10-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase - the Importance of Accommodating the Active Site Water.
Bioorg.Chem., 57, 2014
5UB9
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Catalytic core domain of Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni
Descriptor: ACETATE ION, ATP phosphoribosyltransferase, CHLORIDE ION, ...
Authors:Mittelstaedt, G, Jiao, W, Livingstone, E.K, Parker, E.J.
Deposit date:2016-12-20
Release date:2017-12-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A dimeric catalytic core relates the short and long forms of ATP-phosphoribosyltransferase.
Biochem. J., 475, 2018

 

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