3NV8

The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase in complex with phosphoenol pyruvate and manganese (thesit-free)

Summary for 3NV8

Entry DOI	10.2210/pdb3nv8/pdb
Related	2B7O 3KGF 3NUD 3NUE
Descriptor	Probable 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG, SULFATE ION, MANGANESE (II) ION, ... (8 entities in total)
Functional Keywords	dah7p synthase, shikimate pathway, aromatic amino-acid biosynthesis, evolutionary relationships, augmented tim-barrel structure, tim barrel, aldolase, cytosol, transferase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	2
Total formula weight	102905.88
Authors	Parker, E.J.,Jameson, G.B.,Jiao, W.,Hutton, R.H.,Webby, C.J.,Baker, E.N.,Baker, H.M. (deposition date: 2010-07-08, release date: 2010-07-28, Last modification date: 2023-11-01)
Primary citation	Webby, C.J.,Jiao, W.,Hutton, R.D.,Blackmore, N.J.,Baker, H.M.,Baker, E.N.,Jameson, G.B.,Parker, E.J. Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis J.Biol.Chem., 285:30567-30576, 2010 Cited by PubMed: 20667835 DOI: 10.1074/jbc.M110.111856 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation