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PDB: 558 件

6VM0
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Full length Glycine receptor reconstituted in lipid nanodisc in Gly/IVM-conformation (State-1)
分子名称: (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, ...
著者Kumar, A, Basak, S, Chakrapani, S.
登録日2020-01-27
公開日2020-07-29
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.14 Å)
主引用文献Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs.
Nat Commun, 11, 2020
6VM2
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Full length Glycine receptor reconstituted in lipid nanodisc in Gly/IVM-conformation (State-2)
分子名称: (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, ...
著者Kumar, A, Basak, S, Chakrapani, S.
登録日2020-01-27
公開日2020-07-29
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.34 Å)
主引用文献Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs.
Nat Commun, 11, 2020
6W1Y
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Cryo-EM structure of 5HT3A receptor in presence of Palonosetron
分子名称: (3~{a}~{S})-2-[(3~{S})-1-azabicyclo[2.2.2]octan-3-yl]-3~{a},4,5,6-tetrahydro-3~{H}-benzo[de]isoquinolin-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(4-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Basak, S, Chakrapani, S.
登録日2020-03-04
公開日2021-01-13
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献High-resolution structures of multiple 5-HT 3A R-setron complexes reveal a novel mechanism of competitive inhibition.
Elife, 9, 2020
6VM3
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Full length Glycine receptor reconstituted in lipid nanodisc in Gly/IVM-conformation (State-3)
分子名称: (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, ...
著者Kumar, A, Basak, S, Chakrapani, S.
登録日2020-01-27
公開日2020-07-29
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.07 Å)
主引用文献Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs.
Nat Commun, 11, 2020
4Q13
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Apo Estrogen Receptor Alpha Ligand Binding Domain D538G Mutant with a glucocorticoid receptor-interacting protein 1 NR box II peptide
分子名称: Estrogen receptor, Glucocorticoid receptor-interacting protein 1 NR box II peptide
著者Fanning, S.W, Panchamukhi, S, Greene, G.L.
登録日2014-04-02
公開日2015-04-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.
Elife, 5, 2016
4PXM
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The Estrogen Receptor Alpha Ligand Binding Domain D538G Mutant in Complex with Estradiol and a glucocorticoid receptor-interacting protein 1 NR box II peptide
分子名称: ESTRADIOL, Estrogen receptor, Nuclear receptor coactivator 2
著者Fanning, S.W, Panchamukhi, S, Greene, G.L.
登録日2014-03-24
公開日2015-04-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.
Elife, 5, 2016
6OJ6
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BU of 6oj6 by Molmil
In situ structure of rotavirus VP1 RNA-dependent RNA polymerase (DLP_RNA)
分子名称: Inner capsid protein VP2, RNA-directed RNA polymerase, Template, ...
著者Jenni, S, Salgado, E.N, Herrmann, T, Li, Z, Grant, T, Grigorieff, N, Trapani, S, Estrozi, L.F, Harrison, S.C.
登録日2019-04-10
公開日2019-04-24
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献In situ Structure of Rotavirus VP1 RNA-Dependent RNA Polymerase.
J.Mol.Biol., 431, 2019
1XWR
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BU of 1xwr by Molmil
Crystal structure of the coliphage lambda transcription activator protein CII
分子名称: ISOPROPYL ALCOHOL, Regulatory protein CII
著者Datta, A.B, Panjikar, S, Weiss, M.S, Chakrabarti, P, Parrack, P.
登録日2004-11-02
公開日2005-06-21
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献Structure of {lambda} CII: Implications for recognition of direct-repeat DNA by an unusual tetrameric organization
Proc.Natl.Acad.Sci.USA, 102, 2005
5IRA
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BU of 5ira by Molmil
Expanding Nature's Catalytic Repertoire -Directed Evolution of an Artificial Metalloenzyme for In Vivo Metathesis
分子名称: Artificial Metathesase, [1-[4-[[5-[(3~{a}~{S},4~{S},6~{a}~{R})-2-oxidanylidene-1,3,3~{a},4,6,6~{a}-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]methyl]-2,6-dimethyl-phenyl]-3-(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-1-ium-2-yl]-bis(chloranyl)ruthenium
著者Heinisch, T, Jeschek, M, Reuter, R, Trindler, C, Panke, S, Ward, T.R.
登録日2016-03-12
公開日2016-08-31
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Directed evolution of artificial metalloenzymes for in vivo metathesis.
Nature, 537, 2016
2ALG
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BU of 2alg by Molmil
Crystal structure of peach Pru p3, the prototypic member of the family of plant non-specific lipid transfer protein pan-allergens
分子名称: HEPTANE, HEXAETHYLENE GLYCOL, LAURIC ACID, ...
著者Pasquato, N, Berni, R, Folli, C, Folloni, S, Cianci, M, Pantano, S, Helliwell, J, Zanotti, G.
登録日2005-08-05
公開日2005-11-29
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structure of Peach Pru p 3, the Prototypic Member of the Family of Plant Non-specific Lipid Transfer Protein Pan-allergens
J.Mol.Biol., 356, 2006
2A7A
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BU of 2a7a by Molmil
On the Routine Use of Soft X-Rays in Macromolecular Crystallography, Part III- The Optimal Data Collection Wavelength
分子名称: CALCIUM ION, Concanavalin A, MANGANESE (II) ION, ...
著者Mueller-Dieckmann, C, Panjikar, S, Tucker, P.A, Weiss, M.S.
登録日2005-07-05
公開日2005-07-19
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献On the routine use of soft X-rays in macromolecular crystallography. Part III. The optimal data-collection wavelength.
Acta Crystallogr.,Sect.D, 61, 2005
6BE1
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BU of 6be1 by Molmil
Cryo-EM structure of serotonin receptor
分子名称: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Basak, S, Chakrapani, S.
登録日2017-10-24
公開日2018-02-07
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (4.31 Å)
主引用文献Cryo-EM structure of 5-HT
Nat Commun, 9, 2018
6B5V
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BU of 6b5v by Molmil
Structure of TRPV5 in complex with econazole
分子名称: 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, CALCIUM ION, Transient receptor potential cation channel subfamily V member 5
著者Hughes, T.E.T, Lodowski, D.T, Huynh, K.W, Yazici, A, del Rosario, J, Kapoor, A, Basak, S, Samanta, A, Chakrapani, S, Zhou, Z.H, Filizola, M, Rohacs, T, Han, S, Moiseenkova-Bell, V.Y.
登録日2017-09-29
公開日2017-12-27
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4.8 Å)
主引用文献Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM.
Nat. Struct. Mol. Biol., 25, 2018
3P5C
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BU of 3p5c by Molmil
The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation
分子名称: CALCIUM ION, Low density lipoprotein receptor variant, Proprotein convertase subtilisin/kexin type 9
著者Lo Surdo, P, Bottomley, M.J, Calzetta, A, Settembre, E.C, Cirillo, A, Pandit, S, Ni, Y, Hubbard, B, Sitlani, A, Carfi, A.
登録日2010-10-08
公開日2011-10-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (4.2 Å)
主引用文献Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.
Embo Rep., 12, 2011
3P86
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BU of 3p86 by Molmil
Crystal structure of CTR1 kinase domain mutant D676N in complex with staurosporine
分子名称: STAUROSPORINE, Serine/threonine-protein kinase CTR1
著者Mayerhofer, H, Panneerselvam, S, Mueller-Dieckmann, J.
登録日2010-10-13
公開日2011-10-26
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.496 Å)
主引用文献Protein kinase domain of CTR1 from Arabidopsis thaliana promotes ethylene receptor cross talk.
J. Mol. Biol., 415, 2012
3PPZ
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Crystal structure of CTR1 kinase domain in complex with staurosporine
分子名称: STAUROSPORINE, Serine/threonine-protein kinase CTR1
著者Mayerhofer, H, Panneerselvam, S, Mueller-Dieckmann, J.
登録日2010-11-25
公開日2011-12-07
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献Protein kinase domain of CTR1 from Arabidopsis thaliana promotes ethylene receptor cross talk.
J. Mol. Biol., 415, 2012
1K0M
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BU of 1k0m by Molmil
Crystal structure of a soluble monomeric form of CLIC1 at 1.4 angstroms
分子名称: CHLORIDE INTRACELLULAR CHANNEL PROTEIN 1
著者Harrop, S.J, DeMaere, M.Z, Fairlie, W.D, Reztsova, T, Valenzuela, S.M, Mazzanti, M, Tonini, R, Qiu, M.R, Jankova, L, Warton, K, Bauskin, A.R, Wu, W.M, Pankhurst, S, Campbell, T.J, Breit, S.N, Curmi, P.M.G.
登録日2001-09-19
公開日2001-12-12
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.
J.Biol.Chem., 276, 2001
2Y26
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Transmission defective mutant of Grapevine Fanleaf virus
分子名称: COAT PROTEIN
著者Schellenberger, P, Sauter, C, Lorber, B, Bron, P, Trapani, S, Bergdoll, M, Marmonier, A, Schmitt-Keichinger, C, Lemaire, O, Demangeat, G, Ritzenthaler, C.
登録日2010-12-13
公開日2011-06-08
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Insights Into Viral Determinants of Nematode Mediated Grapevine Fanleaf Virus Transmission.
Plos Pathog., 7, 2011
1K0O
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BU of 1k0o by Molmil
Crystal structure of a soluble form of CLIC1. An intracellular chloride ion channel
分子名称: CHLORIDE INTRACELLULAR CHANNEL PROTEIN 1
著者Harrop, S.J, DeMaere, M.Z, Fairlie, W.D, Reztsova, T, Valenzuela, S.M, Mazzanti, M, Tonini, R, Qiu, M.R, Jankova, L, Warton, K, Bauskin, A.R, Wu, W.M, Pankhurst, S, Campbell, T.J, Breit, S.N, Curmi, P.M.G.
登録日2001-09-19
公開日2001-12-12
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.
J.Biol.Chem., 276, 2001
1K0N
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Chloride Intracellular Channel 1 (CLIC1) complexed with glutathione
分子名称: CHLORIDE INTRACELLULAR CHANNEL PROTEIN 1, GLUTATHIONE
著者Harrop, S.J, DeMaere, M.Z, Fairlie, W.D, Reztsova, T, Valenzuela, S.M, Mazzanti, M, Tonini, R, Qiu, M.R, Jankova, L, Warton, K, Bauskin, A.R, Wu, W.M, Pankhurst, S, Campbell, T.J, Breit, S.N, Curmi, P.M.G.
登録日2001-09-19
公開日2001-12-12
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.
J.Biol.Chem., 276, 2001
6DG8
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Full-length 5-HT3A receptor in a serotonin-bound conformation- State 2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, SEROTONIN, ...
著者Basak, S, Chakrapani, S.
登録日2018-05-17
公開日2018-11-07
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.89 Å)
主引用文献Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3Areceptor.
Nature, 563, 2018
6DG7
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Full-length 5-HT3A receptor in a serotonin-bound conformation- State 1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, SEROTONIN, ...
著者Basak, S, Chakrapani, S.
登録日2018-05-17
公開日2018-11-07
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.32 Å)
主引用文献Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3Areceptor.
Nature, 563, 2018
1Y64
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Bni1p Formin Homology 2 Domain complexed with ATP-actin
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ...
著者Otomo, T, Tomchick, D.R, Otomo, C, Panchal, S.C, Machius, M, Rosen, M.K.
登録日2004-12-03
公開日2005-01-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain
Nature, 433, 2005
3P5B
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The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation
分子名称: CALCIUM ION, Low density lipoprotein receptor variant, Proprotein convertase subtilisin/kexin type 9
著者Lo Surdo, P, Bottomley, M.J, Calzetta, A, Settembre, E.C, Cirillo, A, Pandit, S, Ni, Y, Hubbard, B, Sitlani, A, Carfi, A.
登録日2010-10-08
公開日2011-10-26
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.
Embo Rep., 12, 2011
2A7J
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On the Routine Use of Soft X-Rays in Macromolecular Crystallography, Part III- The Optimal Data Collection Wavelength
分子名称: ACETATE ION, CALCIUM ION, CHLORIDE ION, ...
著者Mueller-Dieckmann, C, Panjikar, S, Tucker, P.A, Weiss, M.S.
登録日2005-07-05
公開日2005-07-19
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献On the routine use of soft X-rays in macromolecular crystallography. Part III. The optimal data-collection wavelength.
Acta Crystallogr.,Sect.D, 61, 2005

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