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PDB: 2916 results

8GJX
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Structure of the human STING receptor bound to 2'3'-cUA
Descriptor: 2'3'-cUA, Stimulator of interferon genes protein
Authors:Morehouse, B.R, Li, Y, Slavik, K.M, Toyoda, H, Kranzusch, P.J.
Deposit date:2023-03-16
Release date:2023-07-05
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:cGLRs are a diverse family of pattern recognition receptors in innate immunity.
Cell, 186, 2023
8GJZ
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Structure of a STING receptor from S. pistillata Sp-STING1 bound to 2'3'-cUA
Descriptor: 2'3'-cUA, Stimulator of interferon genes protein
Authors:Li, Y, Toyoda, H, Slavik, K.M, Morehouse, B.R, Kranzusch, P.J.
Deposit date:2023-03-16
Release date:2023-07-05
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:cGLRs are a diverse family of pattern recognition receptors in innate immunity.
Cell, 186, 2023
2E6W
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Solution structure and calcium binding properties of EF-hands 3 and 4 of calsenilin
Descriptor: CALCIUM ION, Calsenilin
Authors:Yu, L, Sun, C, Mendoza, R, Hebert, E, Pereda-Lopez, A, Hajduk, P.J, Olejniczak, E.T.
Deposit date:2007-01-05
Release date:2007-11-27
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure and calcium-binding properties of EF-hands 3 and 4 of calsenilin.
Protein Sci., 16, 2007
2BCK
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Crystal Structure of HLA-A*2402 Complexed with a telomerase peptide
Descriptor: Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ...
Authors:Rizkallah, P.J, Jakobsen, B.K, Cole, D.K, Gao, G.F.
Deposit date:2005-10-19
Release date:2006-01-10
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of HLA-A*2402 complexed with a telomerase peptide.
Eur.J.Immunol., 36, 2006
2AM1
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sp protein ligand 1
Descriptor: 2,4-DICHLORO-N-(3-CYANO-4,5,6,7-TETRAHYDRO-BENZOTHIOPHEN-2YL)-5-(MORPHOLINE-4-SULFONYL)-BENZAMIDE, GLYCEROL, UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase, ...
Authors:Longenecker, K.L, Stamper, G.F, Hajduk, P.J, Fry, E.H, Jakob, C.G, Harlan, J.E, Edalji, R, Bartley, D.M, Walter, K.A, Solomon, L.R.
Deposit date:2005-08-08
Release date:2006-01-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure
Protein Sci., 14, 2005
4PFK
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PHOSPHOFRUCTOKINASE. STRUCTURE AND CONTROL
Descriptor: 6-O-phosphono-beta-D-fructofuranose, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Evans, P.R, Hudson, P.J.
Deposit date:1988-01-25
Release date:1989-01-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Phosphofructokinase: structure and control.
Philos.Trans.R.Soc.London,Ser.B, 293, 1981
2AU3
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Crystal Structure of the Aquifex aeolicus primase (Zinc Binding and RNA Polymerase Domains)
Descriptor: DNA primase, ZINC ION
Authors:Corn, J.E, Pease, P.J, Hura, G.L, Berger, J.M.
Deposit date:2005-08-26
Release date:2005-11-15
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crosstalk between primase subunits can act to regulate primer synthesis in trans.
Mol.Cell, 20, 2005
1T7W
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Zn-alpha-2-glycoprotein; CHO-ZAG PEG 400
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Zinc-alpha-2-glycoprotein
Authors:Delker, S.L, West Jr, A.P, McDermott, L, Kennedy, M.W, Bjorkman, P.J.
Deposit date:2004-05-11
Release date:2004-12-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystallographic studies of ligand binding by Zn-alpha2-glycoprotein.
J.Struct.Biol., 148, 2004
2AM2
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sp protein ligand 2
Descriptor: 2-CHLORO-N-(3-CYANO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHEN-2-YL)-5-DIETHYLSULFAMOYL-BENZAMIDE, UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase, MurF protein
Authors:Longenecker, K.L, Stamper, G.F, Hajduk, P.J, Fry, E.H, Jakob, C.G, Harlan, J.E, Edalji, R, Bartley, D.M, Walter, K.A, Solomon, L.R.
Deposit date:2005-08-08
Release date:2006-01-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure
Protein Sci., 14, 2005
4PIJ
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X-ray crystal structure of the K11S/K63S double mutant of ubiquitin
Descriptor: GLYCEROL, SULFATE ION, Ubiquitin
Authors:Loll, P.J, Xu, P.J, Schmidt, J, Melideo, S.L.
Deposit date:2014-05-08
Release date:2014-10-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Enhancing ubiquitin crystallization through surface-entropy reduction.
Acta Crystallogr.,Sect.F, 70, 2014
2AYL
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2.0 Angstrom Crystal Structure of Manganese Protoporphyrin IX-reconstituted Ovine Prostaglandin H2 Synthase-1 Complexed With Flurbiprofen
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FLURBIPROFEN, GLYCEROL, ...
Authors:Gupta, K, Selinsky, B.S, Loll, P.J.
Deposit date:2005-09-07
Release date:2006-01-24
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:2.0 angstroms structure of prostaglandin H2 synthase-1 reconstituted with a manganese porphyrin cofactor.
Acta Crystallogr.,Sect.D, 62, 2006
4PIH
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X-ray crystal structure of the K33S mutant of ubiquitin
Descriptor: CALCIUM ION, CHLORIDE ION, Ubiquitin
Authors:Loll, P.J, Xu, P.J, Schmidt, J, Melideo, S.L.
Deposit date:2014-05-08
Release date:2014-10-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Enhancing ubiquitin crystallization through surface-entropy reduction.
Acta Crystallogr.,Sect.F, 70, 2014
2B14
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The crystal structure of 2,4-dinitrophenol in complex with the amyloidogenic variant Transthyretin Leu 55 Pro
Descriptor: 2,4-DINITROPHENOL, Transthyretin
Authors:Morais-de-Sa, E, Neto-Silva, R.M, Pereira, P.J, Saraiva, M.J, Damas, A.M.
Deposit date:2005-09-15
Release date:2006-07-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:The binding of 2,4-dinitrophenol to wild-type and amyloidogenic transthyretin
ACTA CRYSTALLOGR.,SECT.D, 62, 2006
2B16
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The crystal structure of 2,4-dinitrophenol in complex with the amyloidogenic variant Transthyretin Tyr78Phe
Descriptor: 2,4-DINITROPHENOL, Transthyretin
Authors:Morais-de-Sa, E, Neto-Silva, R.M, Pereira, P.J, Saraiva, M.J, Damas, A.M.
Deposit date:2005-09-15
Release date:2006-07-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The binding of 2,4-dinitrophenol to wild-type and amyloidogenic transthyretin
ACTA CRYSTALLOGR.,SECT.D, 62, 2006
2CNH
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Structural Insights into the Design of Nonpeptidic Isothiazolidinone- Containing Inhibitors of Protein Tyrosine Phosphatase 1B
Descriptor: CALCIUM ION, N-[(1S)-1-(1H-BENZIMIDAZOL-2-YL)-2-{4-[(5S)-1,1-DIOXIDO-3-OXOISOTHIAZOLIDIN-5-YL]PHENYL}ETHYL]-4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-SULFONAMIDE, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1
Authors:Ala, P.J, Gonneville, L, Hillman, M, Becker-Pasha, M, Yue, E.W, Douty, B, Wayland, B, Polam, P, Crawley, M.L, McLaughlin, E, Sparks, R.B, Glass, B, Takvorian, A, Combs, A.P, Burn, T.C, Hollis, G.F, Wynn, R.
Deposit date:2006-05-21
Release date:2006-09-27
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Insights Into the Design of Nonpeptidic Isothiazolidinone-Containing Inhibitors of Protein- Tyrosine Phosphatase 1B.
J.Biol.Chem., 281, 2006
2C71
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The structure of a family 4 acetyl xylan esterase from Clostridium thermocellum in complex with a magnesium ion.
Descriptor: GLYCOSIDE HYDROLASE, FAMILY 11:CLOSTRIDIUM CELLULOSOME ENZYME, DOCKERIN TYPE I:POLYSACCHARIDE, ...
Authors:Taylor, E.J, Turkenburg, P.J, Vincent, F, Brzozowski, A.M, Gloster, T.M, Dupont, C, Shareck, F, Centeno, M.S.J, Prates, J.A.M, Ferreira, L.M.A, Fontes, C.M.G.A, Biely, P, Davies, G.J.
Deposit date:2005-11-17
Release date:2006-01-23
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Structure and Activity of Two Metal-Ion Dependent Acetyl Xylan Esterases Involved in Plant Cell-Wall Degradation Reveals a Close Similarity to Peptidoglycan Deacetylases.
J.Biol.Chem., 281, 2006
2CMC
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Structural Basis for Inhibition of Protein Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics
Descriptor: N-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDE, SULFATE ION, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1, ...
Authors:Ala, P.J, Gonneville, L, Hillman, M.C, Becker-Pasha, M, Wei, M, Reid, B.G, Klabe, R, Yue, E.W, Wayland, B, Douty, B, Combs, A.P, Polam, P, Wasserman, Z, Bower, M, Burn, T.C, Hollis, G.F, Wynn, R.
Deposit date:2006-05-04
Release date:2006-08-17
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for Inhibition of Protein-Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics.
J.Biol.Chem., 281, 2006
2CNF
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Structural Insights into the Design of Nonpeptidic Isothiazolidinone- Containing Inhibitors of Protein Tyrosine Phosphatase 1B
Descriptor: (5S)-5-{4-[(2S)-2-(1H-BENZIMIDAZOL-2-YL)-2-(1,3-BENZOTHIAZOL-2-YLAMINO)ETHYL]PHENYL}ISOTHIAZOLIDIN-3-ONE 1,1-DIOXIDE, MAGNESIUM ION, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1
Authors:Ala, P.J, Gonneville, L, Hillman, M, Becker-Pasha, M, Yue, E.W, Douty, B, Wayland, B, Polam, P, Crawley, M.L, McLaughlin, E, Sparks, R.B, Glass, B, Takvorian, A, Combs, A.P, Burn, T.C, Hollis, G.F, Wynn, R.
Deposit date:2006-05-21
Release date:2006-09-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Insights Into the Design of Nonpeptidic Isothiazolidinone-Containing Inhibitors of Protein- Tyrosine Phosphatase 1B.
J.Biol.Chem., 281, 2006
4PIG
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Crystal structure of the ubiquitin K11S mutant
Descriptor: CALCIUM ION, CHLORIDE ION, SODIUM ION, ...
Authors:Loll, P.J, Xu, P.J, Schmidt, J, Melideo, S.L.
Deposit date:2014-05-08
Release date:2014-10-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.952 Å)
Cite:Enhancing ubiquitin crystallization through surface-entropy reduction.
Acta Crystallogr.,Sect.F, 70, 2014
2EUA
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Structure and Mechanism of MenF, the Menaquinone-Specific Isochorismate Synthase from Escherichia Coli
Descriptor: D(-)-TARTARIC ACID, Menaquinone-specific isochorismate synthase
Authors:Kolappan, S, Kisker, C, Zwahlen, J, Zhou, R, Tonge, P.J.
Deposit date:2005-10-28
Release date:2006-12-05
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Lysine 190 is the catalytic base in MenF, the menaquinone-specific isochorismate synthase from Escherichia coli: implications for an enzyme family.
Biochemistry, 46, 2007
3FRU
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NEONATAL FC RECEPTOR, PH 6.5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, BETA-2-MICROGLOBULIN, BETA-MERCAPTOETHANOL, ...
Authors:Vaughn, D.E, Burmeister, W.P, Bjorkman, P.J.
Deposit date:1997-12-22
Release date:1998-06-10
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of pH-dependent antibody binding by the neonatal Fc receptor.
Structure, 6, 1998
2F54
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Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity
Descriptor: Beta-2-microglobulin, Cancer/testis antigen 1B, HLA class I histocompatibility antigen, ...
Authors:Rizkallah, P.J, Jakobsen, B.K, Dunn, S.M, Sami, M.
Deposit date:2005-11-25
Release date:2006-04-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.
Protein Sci., 15, 2006
1T7X
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Zn-alpha-2-glycoprotein; refolded CHO-ZAG PEG 400
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Zinc-alpha-2-glycoprotein
Authors:Delker, S.L, West Jr, A.P, McDermott, L, Kennedy, M.W, Bjorkman, P.J.
Deposit date:2004-05-11
Release date:2004-12-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystallographic studies of ligand binding by Zn-alpha2-glycoprotein.
J.Struct.Biol., 148, 2004
1T7Z
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Zn-alpha-2-glycoprotein; baculo-ZAG no PEG, no glycerol
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Zinc-alpha-2-glycoprotein
Authors:Delker, S.L, West Jr, A.P, McDermott, L, Kennedy, M.W, Bjorkman, P.J.
Deposit date:2004-05-11
Release date:2004-12-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystallographic studies of ligand binding by Zn-alpha2-glycoprotein.
J.Struct.Biol., 148, 2004
1PYN
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DUAL-SITE POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR USING A LINKED FRAGMENT STRATEGY AND A MALONATE HEAD ON THE FIRST SITE
Descriptor: 2-(4-{2-TERT-BUTOXYCARBONYLAMINO-2-[4-(3-HYDROXY-2-METHOXYCARBONYL-PHENOXY)-BUTYLCARBAMOYL]-ETHYL}-PHENOXY)-MALONIC ACID, Protein-tyrosine phosphatase, non-receptor type 1
Authors:Szczepankiewicz, B.G, Liu, G, Hajduk, P.J, Abad-Zapatero, C, Zhonghua, P, Lubben, T, Trevillyan, J.M, Stashko, M, Ballaron, S.J, Liang, H.
Deposit date:2003-07-09
Release date:2003-09-16
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.
Bioorg.Med.Chem.Lett., 13, 2003

225158

数据于2024-09-18公开中

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