2AYL

2.0 Angstrom Crystal Structure of Manganese Protoporphyrin IX-reconstituted Ovine Prostaglandin H2 Synthase-1 Complexed With Flurbiprofen

Summary for 2AYL

Entry DOI	10.2210/pdb2ayl/pdb
Related	1EQG 1EQH 1HT5 1HT8 1PRH 1Q4G
Descriptor	Prostaglandin G/H synthase 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywords	cyclooxygenase, non-steroidal anti-inflammatory drug, peroxidase, prostaglandin synthase, egf-like domain, membrane binding domain, maganese protoporphyrin ix, oxidoreductase
Biological source	Ovis aries (sheep)
Total number of polymer chains	2
Total formula weight	135842.83
Authors	Gupta, K.,Selinsky, B.S.,Loll, P.J. (deposition date: 2005-09-07, release date: 2006-01-24, Last modification date: 2023-08-23)
Primary citation	Gupta, K.,Selinsky, B.S.,Loll, P.J. 2.0 angstroms structure of prostaglandin H2 synthase-1 reconstituted with a manganese porphyrin cofactor. Acta Crystallogr.,Sect.D, 62:151-156, 2006 Cited by PubMed: 16421446 DOI: 10.1107/S0907444905036309 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation