5YFS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5yfs by Molmil](/molmil-images/mine/5yfs) | Crystal structure of ribose-1,5-bisphosphate isomerase mutant C135S from Pyrococcus horikoshii OT3 in complex with ribose-1,5-bisphosphate | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,5-di-O-phosphono-alpha-D-ribofuranose, CHLORIDE ION, ... | Authors: | Gogoi, P, Kanaujia, S.P. | Deposit date: | 2017-09-22 | Release date: | 2018-02-14 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A presumed homologue of the regulatory subunits of eIF2B functions as ribose-1,5-bisphosphate isomerase in Pyrococcus horikoshii OT3. Sci Rep, 8, 2018
|
|
7T8P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7t8p by Molmil](/molmil-images/mine/7t8p) | CRYSTAL STRUCTURE OF T151V CAO1 | Descriptor: | CHLORIDE ION, Carotenoid oxygenase 1, FE (II) ION | Authors: | Daruwalla, A, Kiser, P.D. | Deposit date: | 2021-12-16 | Release date: | 2023-07-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | CRYSTAL STRUCTURE OF T151V CAO1 To Be Published
|
|
7T8Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7t8q by Molmil](/molmil-images/mine/7t8q) | CRYSTAL STRUCTURE OF T151G CAO1 | Descriptor: | CHLORIDE ION, Carotenoid oxygenase 1, FE (II) ION | Authors: | Daruwalla, A, Kiser, P.D. | Deposit date: | 2021-12-16 | Release date: | 2023-07-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | CRYSTAL STRUCTURE OF T151G CAO1 To Be Published
|
|
7TAL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7tal by Molmil](/molmil-images/mine/7tal) | LOV2-DARPIN fusion : D4_deltaDARP | Descriptor: | D4_deltaDARP LOV2-DARPin fusion, FLAVIN MONONUCLEOTIDE, MAGNESIUM ION | Authors: | Mittl, P. | Deposit date: | 2021-12-21 | Release date: | 2023-07-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | LOV2-DARPIN fusion : D4_deltaDARP To Be Published
|
|
6J4F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6j4f by Molmil](/molmil-images/mine/6j4f) | Crystal structure of the AtWRKY2 domain | Descriptor: | DNA (5'-D(*AP*GP*CP*CP*TP*TP*TP*GP*AP*CP*CP*AP*GP*CP*G)-3'), DNA (5'-D(*TP*CP*GP*CP*TP*GP*GP*TP*CP*AP*AP*AP*GP*GP*C)-3'), Probable WRKY transcription factor 2, ... | Authors: | Xu, Y.P, Xu, H, Wang, B, Su, X.D. | Deposit date: | 2019-01-08 | Release date: | 2020-01-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of the AtWRKY2 domain To Be Published
|
|
2JA7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ja7 by Molmil](/molmil-images/mine/2ja7) | CPD lesion containing RNA Polymerase II elongation complex C | Descriptor: | 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP *CP*TP*TP*TP*TTP*CP*CP*BRUP*GP*GP*TP*CP*AP*TP*T)-3', 5'-D(*TP*AP*AP*GP*TP*AP*CP*TP*TP*GP *AP*GP*CP*T)-3', 5'-R(*UP*UP*CP*GP*AP*CP*CP*AP*GP*GP*AP)-3', ... | Authors: | Brueckner, F, Hennecke, U, Carell, T, Cramer, P. | Deposit date: | 2006-11-23 | Release date: | 2007-02-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Cpd Damage Recognition by Transcribing RNA Polymerase II. Science, 315, 2007
|
|
8OXG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8oxg by Molmil](/molmil-images/mine/8oxg) | Crystal structure of human methionine aminopeptidase-2 complexed with (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl N-(trans-4-aminocyclohexyl)carbamate | Descriptor: | MANGANESE (II) ION, Methionine aminopeptidase 2, [(1~{R},2~{S},3~{S},4~{R})-2-methoxy-4-methyl-3-[(2~{R},3~{S})-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-4-oxidanyl-cyclohexyl] ~{N}-(4-azanylcyclohexyl)carbamate | Authors: | Moss, S, Cornelius, P. | Deposit date: | 2023-05-02 | Release date: | 2024-04-10 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.731 Å) | Cite: | Pharmacological Characterization of SDX-7320/Evexomostat: A Novel Methionine Aminopeptidase Type 2 Inhibitor with Anti-tumor and Anti-metastatic Activity. Mol.Cancer Ther., 23, 2024
|
|
6S9M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6s9m by Molmil](/molmil-images/mine/6s9m) | Designed Armadillo Repeat protein Lock2 fused to target peptide KRKRKAKITW | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Lock2_KRKRKAKITW, ... | Authors: | Ernst, P, Zosel, F, Reichen, C, Schuler, B, Pluckthun, A. | Deposit date: | 2019-07-15 | Release date: | 2020-02-19 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-Guided Design of a Peptide Lock for Modular Peptide Binders. Acs Chem.Biol., 15, 2020
|
|
6YGG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ygg by Molmil](/molmil-images/mine/6ygg) | NADase from Aspergillus fumigatus complexed with a substrate anologue | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, AfNADase, ... | Authors: | Stromland, O, Ziegler, M, Kallio, J.P. | Deposit date: | 2020-03-27 | Release date: | 2020-12-23 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Discovery of fungal surface NADases predominantly present in pathogenic species. Nat Commun, 12, 2021
|
|
8HIC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8hic by Molmil](/molmil-images/mine/8hic) | Crystal structure of UrtA from Prochlorococcus marinus str. MIT 9313 in complex with urea and calcium | Descriptor: | CALCIUM ION, Putative urea ABC transporter, substrate binding protein, ... | Authors: | Zhang, Y.Z, Wang, P, Wang, C. | Deposit date: | 2022-11-19 | Release date: | 2023-11-22 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural and molecular basis for urea recognition by Prochlorococcus. J.Biol.Chem., 299, 2023
|
|
8CUK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8cuk by Molmil](/molmil-images/mine/8cuk) | |
5ALB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5alb by Molmil](/molmil-images/mine/5alb) | Ticagrelor antidote candidate MEDI2452 in complex with ticagrelor | Descriptor: | MEDI2452 HEAVY CHAIN, MEDI2452 LIGHT CHAIN, Ticagrelor | Authors: | Buchanan, A, Newton, P, Pehrsson, S, Inghardt, T, Antonsson, T, Svensson, P, Sjogren, T, Oster, L, Janefeldt, A, Sandinge, A, Keyes, F, Austin, M, Spooner, J, Penney, M, Howells, G, Vaughan, T, Nylander, S. | Deposit date: | 2015-03-07 | Release date: | 2015-04-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Structural and Functional Characterisation of a Specific Antidote for Ticagrelor. Blood, 125, 2015
|
|
5ESP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5esp by Molmil](/molmil-images/mine/5esp) | |
6ATU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6atu by Molmil](/molmil-images/mine/6atu) | |
8D5I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8d5i by Molmil](/molmil-images/mine/8d5i) | Crystal structure of dihydropteroate synthase H182G mutant (folP-SMZ_B27) from soil uncultured bacterium in complex with pteroic acid and pyrophosphate | Descriptor: | PTEROIC ACID, PYROPHOSPHATE 2-, folP-SMZ_B27 | Authors: | Stogios, P.J, Skarina, T, Kim, Y, Di Leo, R, Venkatesan, M, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2022-06-04 | Release date: | 2022-06-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Crystal structure of dihydropteroate synthase H182G mutant (folP-SMZ_B27) from soil uncultured bacterium in complex with pteroic acid To Be Published
|
|
8D5G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8d5g by Molmil](/molmil-images/mine/8d5g) | Crystal structure of dihydropteroate synthase (folP-SMZ_B27) from soil uncultured bacterium in complex with 6-hydroxymethyl-7,8-dihydropterin pyrophosphate | Descriptor: | 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE, CHLORIDE ION, folP-SMZ_B27 | Authors: | Stogios, P.J, Skarina, T, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2022-06-04 | Release date: | 2022-06-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | Crystal structure of dihydropteroate synthase (folP-SMZ_B27) from soil uncultured bacterium in complex with 6-hydroxymethyl-7,8-dihydropterin pyrophosphate To Be Published
|
|
6AUP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6aup by Molmil](/molmil-images/mine/6aup) | Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox | Descriptor: | GLYCEROL, Potassium channel toxin gamma-KTx 2.2, SULFATE ION | Authors: | Gewe, M.M, Rupert, P, Strong, R.K. | Deposit date: | 2017-09-01 | Release date: | 2018-02-28 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Screening, large-scale production and structure-based classification of cystine-dense peptides. Nat. Struct. Mol. Biol., 25, 2018
|
|
6EY0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ey0 by Molmil](/molmil-images/mine/6ey0) | N-terminal part (residues 30-212) of PorM with the llama nanobody nb01 | Descriptor: | T9SS component cytoplasmic membrane protein PorM, llama nanobody nb01 | Authors: | Leone, P, Roche, J, Cambillau, C, Roussel, A. | Deposit date: | 2017-11-10 | Release date: | 2018-02-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Type IX secretion system PorM and gliding machinery GldM form arches spanning the periplasmic space. Nat Commun, 9, 2018
|
|
6YKD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ykd by Molmil](/molmil-images/mine/6ykd) | Human Pim-1 kinase in complex with an inhibitor identified by virtual screening | Descriptor: | ACETATE ION, GLYCEROL, Serine/threonine-protein kinase pim-1, ... | Authors: | Schneider, P, Welin, M, Svensson, B, Walse, B, Schneider, G. | Deposit date: | 2020-04-06 | Release date: | 2020-07-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Virtual Screening and Design with Machine Intelligence Applied to Pim-1 Kinase Inhibitors. Mol Inform, 39, 2020
|
|
6AZZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6azz by Molmil](/molmil-images/mine/6azz) | Crystal structure of Pfs25 in complex with the transmission blocking antibody 1190 | Descriptor: | 1190 antibody, heavy chain, light chain, ... | Authors: | Scally, S.W, McLeod, B, Bosch, A, King, C.R, Julien, J.P. | Deposit date: | 2017-09-13 | Release date: | 2017-11-08 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25. Nat Commun, 8, 2017
|
|
2V9W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2v9w by Molmil](/molmil-images/mine/2v9w) | Complex structure of Sulfolobus solfataricus DPO4 and DNA duplex containing a hydrophobic thymine isostere 2,4-difluorotoluene nucleotide in the template strand | Descriptor: | 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *CP*TP*G)-3', 5'-D(*TP*TP*CP*AP*GP*DFTP*AP*GP*TP*CP*CP *TP*TP*CP*CP*CP*CP*C)-3', ... | Authors: | Irimia, A, Pallan, P.S, Egli, M. | Deposit date: | 2007-08-27 | Release date: | 2007-10-30 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure and Activity of Y-Class DNA Polymerase Dpo4 from Sulfolobus Solfataricus with Templates Containing the Hydrophobic Thymine Analog 2,4-Difluorotoluene. J.Biol.Chem., 282, 2007
|
|
6SCY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6scy by Molmil](/molmil-images/mine/6scy) | U34-tRNA thiolase NcsA from Methanococcus maripaludis with its [4Fe-4S] cluster | Descriptor: | IRON/SULFUR CLUSTER, SULFATE ION, ZINC ION, ... | Authors: | Bimai, O, Legrand, P, Golinelli-Pimpaneau, B. | Deposit date: | 2019-07-25 | Release date: | 2020-08-26 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | The thiolation of uridine 34 in tRNA, which controls protein translation, depends on a [4Fe-4S] cluster in the archaeum Methanococcus maripaludis. Sci Rep, 13, 2023
|
|
6B0W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6b0w by Molmil](/molmil-images/mine/6b0w) | Crystal structure of the anti-circumsporozoite protein 1710 antibody | Descriptor: | 1710 antibody, heavy chain, light chain, ... | Authors: | Scally, S.W, Murugan, R, Bosch, A, Triller, G, Wardemann, H, Julien, J.P. | Deposit date: | 2017-09-15 | Release date: | 2017-11-08 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection. J. Exp. Med., 215, 2018
|
|
6JB0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6jb0 by Molmil](/molmil-images/mine/6jb0) | Crystal structure of ABC transporter alpha-glycoside-binding mutant protein W287A in complex with trehalose | Descriptor: | 1,2-ETHANEDIOL, 1,3-PROPANDIOL, ABC transporter, ... | Authors: | Kanaujia, S.P, Chandravanshi, M, Gogoi, P. | Deposit date: | 2019-01-25 | Release date: | 2019-10-30 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Structural and thermodynamic correlation illuminates the selective transport mechanism of disaccharide alpha-glycosides through ABC transporter. Febs J., 287, 2020
|
|
6JBG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6jbg by Molmil](/molmil-images/mine/6jbg) | Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neamine analog (equatorial 4'-F) | Descriptor: | (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,4,6-trideoxy-4-fluoro-alpha-D-glucopyranoside, RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3'), RNA (5'-R(P*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') | Authors: | Kanazawa, H, Auffinger, P, Hanessian, S, Kondo, J. | Deposit date: | 2019-01-25 | Release date: | 2020-01-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neamine analog (axial 4'-F) To Be Published
|
|