8OXG

Crystal structure of human methionine aminopeptidase-2 complexed with (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl N-(trans-4-aminocyclohexyl)carbamate

Summary for 8OXG

• Entry DOI: 10.2210/pdb8oxg/pdb
• Descriptor: Methionine aminopeptidase 2, [(1~{R},2~{S},3~{S},4~{R})-2-methoxy-4-methyl-3-[(2~{R},3~{S})-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-4-oxidanyl-cyclohexyl] ~{N}-(4-azanylcyclohexyl)carbamate, MANGANESE (II) ION, ... (4 entities in total)
• Functional Keywords: aminopeptidase hydrolase inhibitor protease metal-binding, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 87599.03

Authors

Moss, S.,Cornelius, P. (deposition date: 2023-05-02, release date: 2024-04-10, Last modification date: 2024-05-15)

• Primary citation: Cornelius, P.,Mayes, B.A.,Petersen, J.S.,Turnquist, D.J.,Dufour, P.J.,Dannenberg, A.J.,Shanahan, J.M.,Carver, B.J.; Pharmacological Characterization of SDX-7320/Evexomostat: A Novel Methionine Aminopeptidase Type 2 Inhibitor with Anti-tumor and Anti-metastatic Activity.; Mol.Cancer Ther., 23:595-605, 2024; PubMed: 38530115; DOI: 10.1158/1535-7163.MCT-23-0574

Experimental method

X-RAY DIFFRACTION (1.731 Å)