8OXG

Crystal structure of human methionine aminopeptidase-2 complexed with (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl N-(trans-4-aminocyclohexyl)carbamate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Methionine aminopeptidase 2	polymer	384	43265.1	2	UniProt (P50579) Pfam (PF00557)	Homo sapiens (human)	MAP 2,MetAP 2,Initiation factor 2-associated 67 kDa glycoprotein,p67,p67eIF2,Peptidase M
2	C, F (A, B)	[(1~{R},2~{S},3~{S},4~{R})-2-methoxy-4-methyl-3-[(2~{R},3~{S})-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-4-oxidanyl-cyclohexyl] ~{N}-(4-azanylcyclohexyl)carbamate	non-polymer		424.6	2	Chemie (W5N)
3	D, E, G, H (A, B)	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)
4	I, J (A, B)	water	water		18.0	568	Chemie (HOH)

Sequence modifications

A, B: 108 - 478 (UniProt: P50579)

PDB	External Database	Details
Met 95	-	initiating methionine
His 96	-	expression tag
His 97	-	expression tag
His 98	-	expression tag
His 99	-	expression tag
His 100	-	expression tag
His 101	-	expression tag
Glu 102	-	expression tag
Asn 103	-	expression tag
Leu 104	-	expression tag
Tyr 105	-	expression tag
Phe 106	-	expression tag
Gln 107	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	86530.1
Non-Polymers*	Number of molecules	6
	Total formula weight	1068.9
All*	Total formula weight	87599.0

*Water molecules are not included.