8VT2
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![BU of 8vt2 by Molmil](/molmil-images/mine/8vt2) | cryo-EM structure of HMPV (MPV-2c) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Prefusion of HMPV (MPV-2c), ... | Authors: | Yu, X, Langedijk, J.P.M. | Deposit date: | 2024-01-25 | Release date: | 2024-07-31 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | Efficacious human metapneumovirus vaccine based on AI-guided engineering of a closed prefusion trimer. Nat Commun, 15, 2024
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8BAY
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![BU of 8bay by Molmil](/molmil-images/mine/8bay) | Crystal Structure of IDH1 variant R132C S280F in complex with NADPH, Ca2+ and 3-butyl-2-oxoglutarate | Descriptor: | (R)-3-butyl-2-oxopentanedioic acid, (S)-3-butyl-2-oxopentanedioic acid, CALCIUM ION, ... | Authors: | Rabe, P, Schofield, C.J, Reinbold, R, Brewitz, L. | Deposit date: | 2022-10-12 | Release date: | 2022-11-02 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Natural and synthetic 2-oxoglutarate derivatives are substrates for oncogenic variants of human isocitrate dehydrogenase 1 and 2. J.Biol.Chem., 299, 2023
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8POV
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![BU of 8pov by Molmil](/molmil-images/mine/8pov) | Crystal Structure of the C19G/C120G variant of the membrane-bound [NiFe]-Hydrogenase from Cupriavidus necator in the H2-reduced state at 1.92 A Resolution. | Descriptor: | FE3-S4 CLUSTER, IRON/SULFUR CLUSTER, MAGNESIUM ION, ... | Authors: | Schmidt, A, Kalms, J, Scheerer, P. | Deposit date: | 2023-07-05 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Stepwise conversion of the Cys 6 [4Fe-3S] to a Cys 4 [4Fe-4S] cluster and its impact on the oxygen tolerance of [NiFe]-hydrogenase. Chem Sci, 14, 2023
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6H0W
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![BU of 6h0w by Molmil](/molmil-images/mine/6h0w) | Crystal Structure of KDM4D with tetrazolylhydrazide ligand NS035 | Descriptor: | (2~{R})-3-phenyl-2-(2~{H}-1,2,3,4-tetrazol-5-yl)propanehydrazide, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Malecki, P.H, Weiss, M.S, Heinemann, U, Link, A. | Deposit date: | 2018-07-10 | Release date: | 2020-01-29 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.23 Å) | Cite: | Crystal Structure of KDM4D with tetrazolylhydrazide ligand NS035 To be published
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6H3S
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![BU of 6h3s by Molmil](/molmil-images/mine/6h3s) | Schmallenberg Virus Glycoprotein Gc Head/Stalk Domains | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Envelopment polyprotein, ... | Authors: | Hellert, J, Aebischer, A, Wernike, K, Haouz, A, Brocchi, E, Reiche, S, Guardado-Calvo, P, Beer, M, Rey, F.A. | Deposit date: | 2018-07-19 | Release date: | 2019-02-27 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.023 Å) | Cite: | Orthobunyavirus spike architecture and recognition by neutralizing antibodies. Nat Commun, 10, 2019
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8VPX
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![BU of 8vpx by Molmil](/molmil-images/mine/8vpx) | UIC-10-BPE extension of UIC-1 | Descriptor: | UIC-10-BPE | Authors: | Ganatra, P. | Deposit date: | 2024-01-17 | Release date: | 2024-08-07 | Last modified: | 2024-08-14 | Method: | X-RAY DIFFRACTION (1.451 Å) | Cite: | Diverse Proteomimetic Frameworks via Rational Design of pi-Stacking Peptide Tectons. J.Am.Chem.Soc., 2024
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1MK6
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![BU of 1mk6 by Molmil](/molmil-images/mine/1mk6) | SOLUTION STRUCTURE OF THE 8,9-DIHYDRO-8-(N7-GUANYL)-9-HYDROXY-AFLATOXIN B1 ADDUCT MISPAIRED WITH DEOXYADENOSINE | Descriptor: | 5'-D(*AP*CP*AP*TP*CP*GP*AP*TP*CP*T)-3', 5'-D(*AP*GP*AP*TP*AP*GP*AP*TP*GP*T)-3', 8,9-DIHYDRO-9-HYDROXY-AFLATOXIN B1 | Authors: | Giri, I, Johnston, D.S, Stone, M.P. | Deposit date: | 2002-08-28 | Release date: | 2002-10-16 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | MISPAIRING OF THE 8,9-DIHYDRO-8-(N7-GUANYL)-9-HYDROXY-AFLATOXIN B1 ADDUCT WITH DEOXYADENOSINE RESULTS IN EXTRUSION OF THE MISMATCHED DA TOWARD THE MAJOR GROOVE Biochemistry, 41, 2002
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8POE
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![BU of 8poe by Molmil](/molmil-images/mine/8poe) | Structure of tissue-specific lipid scramblase ATG9B homotrimer, refined with C3 symmetry applied | Descriptor: | Autophagy-related protein 9B | Authors: | Chiduza, G.N, Pye, V.E, Tooze, S.A, Cherepanov, P. | Deposit date: | 2023-07-04 | Release date: | 2023-11-15 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A. Autophagy, 20, 2024
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1HH4
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![BU of 1hh4 by Molmil](/molmil-images/mine/1hh4) | Rac1-RhoGDI complex involved in NADPH oxidase activation | Descriptor: | GERAN-8-YL GERAN, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Grizot, S, Faure, J, Fieschi, F, Vignais, P.V, Dagher, M.-C, Pebay-Peyroula, E. | Deposit date: | 2000-12-20 | Release date: | 2001-08-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal Structure of the Rac1-Rhogdi Complex Involved in Nadph Oxidase Activation Biochemistry, 40, 2001
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4S0X
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![BU of 4s0x by Molmil](/molmil-images/mine/4s0x) | Structure of three phase partition - treated lipase from Thermomyces lanuginosa in complex with lauric acid at 2.1 A resolution | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-nitrobenzaldehyde, ... | Authors: | Kumar, M, Mukherjee, J, Gupta, M.N, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2015-01-07 | Release date: | 2015-02-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of three phase partition - treated lipase from Thermomyces lanuginosa in complex with lauric acid at 2.1 A resolution To be Published
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4DJI
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![BU of 4dji by Molmil](/molmil-images/mine/4dji) | Structure of glutamate-GABA antiporter GadC | Descriptor: | Probable glutamate/gamma-aminobutyrate antiporter | Authors: | Ma, D, Lu, P.L, Yan, C.Y, Fan, C, Yin, P, Wang, J.W, Shi, Y.G. | Deposit date: | 2012-02-02 | Release date: | 2012-03-14 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.187 Å) | Cite: | Structure and mechanism of a glutamate-GABA antiporter Nature, 483, 2012
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8QCB
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![BU of 8qcb by Molmil](/molmil-images/mine/8qcb) | CryoEM structure of a S. Cerevisiae Ski2387 complex in the open state | Descriptor: | Antiviral helicase SKI2, Antiviral protein SKI8, Superkiller protein 3, ... | Authors: | Keidel, A, Koegel, A, Reichelt, P, Kowalinski, E, Schaefer, I.B, Conti, E. | Deposit date: | 2023-08-25 | Release date: | 2023-11-08 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly. Mol.Cell, 83, 2023
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4DAJ
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![BU of 4daj by Molmil](/molmil-images/mine/4daj) | Structure of the M3 Muscarinic Acetylcholine Receptor | Descriptor: | (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, Muscarinic acetylcholine receptor M3, Lysozyme, ... | Authors: | Kruse, A.C, Hu, J, Pan, A.C, Arlow, D.H, Rosenbaum, D.M, Rosemond, E, Green, H.F, Liu, T, Chae, P.S, Dror, R.O, Shaw, D.E, Weis, W.I, Wess, J, Kobilka, B. | Deposit date: | 2012-01-12 | Release date: | 2012-02-22 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature, 482, 2012
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8VOG
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![BU of 8vog by Molmil](/molmil-images/mine/8vog) | UIC-12-BIF extension of UIC-1 | Descriptor: | ACETONITRILE, UIC-12-BIF | Authors: | Ganatra, P. | Deposit date: | 2024-01-15 | Release date: | 2024-08-07 | Last modified: | 2024-08-14 | Method: | X-RAY DIFFRACTION (0.94 Å) | Cite: | Diverse Proteomimetic Frameworks via Rational Design of pi-Stacking Peptide Tectons. J.Am.Chem.Soc., 2024
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5NX2
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![BU of 5nx2 by Molmil](/molmil-images/mine/5nx2) | Crystal structure of thermostabilised full-length GLP-1R in complex with a truncated peptide agonist at 3.7 A resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glucagon-like peptide 1 receptor, ... | Authors: | Rappas, M, Jazayeri, A, Brown, A.J.H, Kean, J, Errey, J.C, Robertson, N, Fiez-Vandal, C, Andrews, S.P, Congreve, M, Bortolato, A, Mason, J.S, Baig, A.H, Teobald, I, Dore, A.S, Weir, M, Cooke, R.M, Marshall, F.H. | Deposit date: | 2017-05-09 | Release date: | 2017-06-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Crystal structure of the GLP-1 receptor bound to a peptide agonist. Nature, 546, 2017
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5VQB
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![BU of 5vqb by Molmil](/molmil-images/mine/5vqb) | Crystal structure of rifampin monooxygenase from Streptomyces venezuelae, complex with FAD | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Cox, G, Kelso, J, Stogios, P.J, Savchenko, A, Anderson, W.F, Wright, G.D, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2017-05-08 | Release date: | 2017-08-16 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.391 Å) | Cite: | Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action. Cell Chem Biol, 25, 2018
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8VW7
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![BU of 8vw7 by Molmil](/molmil-images/mine/8vw7) | UIC-11-BPE-AgNO3 silver binding with UIC-11-BPE | Descriptor: | NITRATE ION, SILVER ION, UIC-11-BPE-AgNO3 | Authors: | Ganatra, P. | Deposit date: | 2024-01-31 | Release date: | 2024-08-07 | Last modified: | 2024-08-14 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Diverse Proteomimetic Frameworks via Rational Design of pi-Stacking Peptide Tectons. J.Am.Chem.Soc., 2024
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3V4A
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![BU of 3v4a by Molmil](/molmil-images/mine/3v4a) | Structure of ar lbd with activator peptide and sarm inhibitor 2 | Descriptor: | (5R)-3-(3,4-dichlorophenyl)-5-(4-hydroxyphenyl)-1,5-dimethyl-2-thioxoimidazolidin-4-one, Androgen receptor, SULFATE ION | Authors: | Nique, F, Hebbe, S, Peixoto, C, Annoot, D, Lefrancois, J.-M, Duval, E, Michoux, L, Triballeau, N, Lemoullec, J.M, Mollat, P, Thauvin, M, Prange, T, Minet, D, Clement-Lacroix, P, Robin-Jagerschmidt, C, Fleury, D, Guedin, D, Deprez, P. | Deposit date: | 2011-12-14 | Release date: | 2012-09-05 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Discovery of diarylhydantoins as new selective androgen receptor modulators. J.Med.Chem., 55, 2012
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6LOU
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![BU of 6lou by Molmil](/molmil-images/mine/6lou) | Crystal structure of DUSP22 mutant_C88S/S93N | Descriptor: | Dual specificity protein phosphatase 22, PHOSPHATE ION | Authors: | Lai, C.H, Lyu, P.C. | Deposit date: | 2020-01-07 | Release date: | 2020-10-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.5301 Å) | Cite: | Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases. Int J Mol Sci, 21, 2020
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8A9M
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![BU of 8a9m by Molmil](/molmil-images/mine/8a9m) | Hippeastrum hybrid agglutinin, HHA, complex with beta-mannose | Descriptor: | Agglutinin, PHOSPHATE ION, beta-D-mannopyranose | Authors: | Rizkallah, P.J. | Deposit date: | 2022-06-28 | Release date: | 2022-10-05 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | X-ray structure solution of amaryllis lectin by molecular replacement with only 4% of the total diffracting matter. Acta Crystallogr D Biol Crystallogr, 52, 1996
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2BLC
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![BU of 2blc by Molmil](/molmil-images/mine/2blc) | SP21 double mutant P. vivax Dihydrofolate reductase in complex with des-chloropyrimethamine | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINE, DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE, ... | Authors: | Kongsaeree, P, Khongsuk, P, Leartsakulpanich, U, Chitnumsub, P, Tarnchompoo, B, Walkinshaw, M.D, Yuthavong, Y. | Deposit date: | 2005-03-03 | Release date: | 2005-09-07 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Crystal Structure of Dihydrofolate Reductase from Plasmodium Vivax: Pyrimethamine Displacement Linked with Mutation-Induced Resistance. Proc.Natl.Acad.Sci.USA, 102, 2005
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6H64
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![BU of 6h64 by Molmil](/molmil-images/mine/6h64) | Crystal structure of the CRD-SAT | Descriptor: | Galectin-3, SULFATE ION, beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Charron, C, Kriznik, A, Yelehe-Okouma, M, Jouzeau, J.-Y, Reboul, P. | Deposit date: | 2018-07-26 | Release date: | 2019-08-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | CRD SAT Generated by pCARGHO: A New Efficient Lectin-Based Affinity Tag Method for Safe, Simple, and Low-Cost Protein Purification. Biotechnol J, 14, 2019
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4DGF
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![BU of 4dgf by Molmil](/molmil-images/mine/4dgf) | Structure of SulP Transporter STAS Domain from Wolinella Succinogenes Refined to 1.6 Angstrom Resolution | Descriptor: | CHLORIDE ION, FORMIC ACID, SULFATE TRANSPORTER SULFATE TRANSPORTER FAMILY PROTEIN | Authors: | Keller, J.P, Chang, C, Tesar, C, Bearden, J, Dallos, P, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2012-01-25 | Release date: | 2012-02-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of SulP Transporter STAS Domain from Wolinella Succinogenes Refined to 1.6 Angstrom Resolution To be Published
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6LVQ
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![BU of 6lvq by Molmil](/molmil-images/mine/6lvq) | Crystal structure of DUSP22_VO4 | Descriptor: | Dual specificity protein phosphatase 22, VANADATE ION | Authors: | Lai, C.H, Lyu, P.C. | Deposit date: | 2020-02-04 | Release date: | 2020-10-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases. Int J Mol Sci, 21, 2020
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1V4K
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![BU of 1v4k by Molmil](/molmil-images/mine/1v4k) | Crystal Structure of Octaprenyl Pyrophosphate Synthase from Hyperthermophilic Thermotoga maritima S77F mutant | Descriptor: | SULFATE ION, octoprenyl-diphosphate synthase | Authors: | Guo, R.T, Kuo, C.J, Chou, C.C, Ko, T.P, Shr, H.L, Liang, P.H, Wang, A.H.-J. | Deposit date: | 2003-11-14 | Release date: | 2004-03-02 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Crystal Structure of Octaprenyl Pyrophosphate Synthase from Hyperthermophilic Thermotoga maritima and Mechanism of Product Chain Length Determination J.Biol.Chem., 279, 2004
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