2BLC

SP21 double mutant P. vivax Dihydrofolate reductase in complex with des-chloropyrimethamine

Summary for 2BLC

Entry DOI	10.2210/pdb2blc/pdb
Related	2BL9 2BLA 2BLB
Descriptor	DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINE, ... (5 entities in total)
Functional Keywords	dihydrofolate reductase, plasmodium vivax, malaria, drug resistance, thymidylate synthase, pyrimethamine, double mutant, oxidoreductase
Biological source	PLASMODIUM VIVAX
Total number of polymer chains	1
Total formula weight	28421.09
Authors	Kongsaeree, P.,Khongsuk, P.,Leartsakulpanich, U.,Chitnumsub, P.,Tarnchompoo, B.,Walkinshaw, M.D.,Yuthavong, Y. (deposition date: 2005-03-03, release date: 2005-09-07, Last modification date: 2019-05-22)
Primary citation	Kongsaeree, P.,Khongsuk, P.,Leartsakulpanich, U.,Chitnumsub, P.,Tarnchompoo, B.,Walkinshaw, M.D.,Yuthavong, Y. Crystal Structure of Dihydrofolate Reductase from Plasmodium Vivax: Pyrimethamine Displacement Linked with Mutation-Induced Resistance. Proc.Natl.Acad.Sci.USA, 102:13046-, 2005 Cited by PubMed: 16135570 DOI: 10.1073/PNAS.0501747102 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation