2BLB
X-ray crystal structure of Plasmodium vivax dihydrofolate reductase in complex with pyrimethamine and its derivative
Summary for 2BLB
Entry DOI | 10.2210/pdb2blb/pdb |
Related | 2BL9 2BLA 2BLC |
Descriptor | DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINE, ... (5 entities in total) |
Functional Keywords | dihydrofolate reductase, plamodium vivax, pyrimethamine, malaria, drug resistance, oxidoreductase |
Biological source | PLASMODIUM VIVAX |
Total number of polymer chains | 1 |
Total formula weight | 28265.92 |
Authors | Kongsaeree, P.,Khongsuk, P.,Leartsakulpanich, U.,Chitnumsub, P.,Tarnchompoo, B.,Walkinshaw, M.D.,Yuthavong, Y. (deposition date: 2005-03-03, release date: 2005-09-07, Last modification date: 2024-05-08) |
Primary citation | Kongsaeree, P.,Khongsuk, P.,Leartsakulpanich, U.,Chitnumsub, P.,Tarnchompoo, B.,Walkinshaw, M.D.,Yuthavong, Y. Crystal Structure of Dihydrofolate Reductase from Plasmodium Vivax: Pyrimethamine Displacement Linked with Mutation-Induced Resistance. Proc.Natl.Acad.Sci.USA, 102:13046-, 2005 Cited by PubMed: 16135570DOI: 10.1073/PNAS.0501747102 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
Download full validation report