3NX9
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![BU of 3nx9 by Molmil](/molmil-images/mine/3nx9) | Crystal structure of type I ribosome inactivating protein in complex with maltose at 1.7A resolution | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Ribosome inactivating protein, ... | 著者 | Pandey, N, Kushwaha, G.S, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | 登録日 | 2010-07-13 | 公開日 | 2010-08-04 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure of type I ribosome inactivating protein in complex with maltose at 1.7A resolution To be Published
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5LOF
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![BU of 5lof by Molmil](/molmil-images/mine/5lof) | Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1 | 分子名称: | (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluoranylfuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-[2,2,2-tris(fluoranyl)ethyl]pyrazol-3-yl]methoxy]phenyl]propanoic acid, Maltose-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Dokurno, P, Kotschy, A, Szlavik, Z, Murray, J, Davidson, J, Csekei, M, Paczal, A, Szabo, Z, Sipos, S, Radics, G, Proszenyak, A, Balint, B, Ondi, L, Blasko, G, Robertson, A, Surgenor, A, Chen, I, Matassova, N, Smith, J, Pedder, C, Graham, C, Geneste, O. | 登録日 | 2016-08-09 | 公開日 | 2016-10-26 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models. Nature, 538, 2016
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5LFA
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![BU of 5lfa by Molmil](/molmil-images/mine/5lfa) | Crystal structure of iron-sulfur cluster containing bacterial (6-4) photolyase PhrB - Y424F mutant with impaired DNA repair activity | 分子名称: | (6-4) photolyase, 1-deoxy-1-(6,7-dimethyl-2,4-dioxo-3,4-dihydropteridin-8(2H)-yl)-D-ribitol, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Kwiatkowski, D, Zhang, F, Krauss, N, Lamparter, T, Scheerer, P. | 登録日 | 2016-06-30 | 公開日 | 2017-01-11 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structures of Bacterial (6-4) Photolyase Mutants with Impaired DNA Repair Activity. Photochem. Photobiol., 93, 2017
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3ETP
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![BU of 3etp by Molmil](/molmil-images/mine/3etp) | The crystal structure of the ligand-binding domain of the EphB2 receptor at 2.0 A resolution | 分子名称: | Ephrin type-B receptor 2 | 著者 | Goldgur, Y, Paavilainen, S, Nikolov, D.B, Himanen, J.P. | 登録日 | 2008-10-08 | 公開日 | 2008-10-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of the ligand-binding domain of the EphB2 receptor at 2 A resolution. Acta Crystallogr.,Sect.F, 65, 2009
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3ETU
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9FFH
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![BU of 9ffh by Molmil](/molmil-images/mine/9ffh) | Native capsid of Rhodobacter microvirus Ebor computed with I4 symmetry | 分子名称: | Major capsid protein | 著者 | Bardy, P, MacDonald, C.I.W, Jenkins, H.T, Chechik, M, Hart, S.J, Turkenburg, J.P, Blaza, J.N, Fogg, P.C.M, Antson, A.A. | 登録日 | 2024-05-23 | 公開日 | 2024-06-12 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | A stargate mechanism of Microviridae genome delivery unveiled by cryogenic electron tomography. Biorxiv, 2024
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3EU1
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![BU of 3eu1 by Molmil](/molmil-images/mine/3eu1) | Crystal Structure determination of goat hemoglobin (Capra hircus) at 3 angstrom resolution | 分子名称: | Hemoglobin subunit alpha-1/2, Hemoglobin subunit beta-A, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Sathya Moorthy, P, Neelagandan, K, Balasubramanian, M, Ponnuswamy, M.N. | 登録日 | 2008-10-09 | 公開日 | 2009-11-10 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Purification, crystallization and preliminary X-ray diffraction studies on goat (Capra hircus) hemoglobin - a low oxygen affinity species Protein Pept.Lett., 16, 2009
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9FFG
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![BU of 9ffg by Molmil](/molmil-images/mine/9ffg) | Empty capsid of Rhodobacter microvirus Ebor computed with I4 symmetry | 分子名称: | Major capsid protein | 著者 | Bardy, P, MacDonald, C.I.W, Jenkins, H.T, Byrom, L, Chechik, M, Hart, S.J, Turkenburg, J.P, Blaza, J.N, Fogg, P.C.M, Antson, A.A. | 登録日 | 2024-05-23 | 公開日 | 2024-06-12 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | A stargate mechanism of Microviridae genome delivery unveiled by cryogenic electron tomography. Biorxiv, 2024
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3E8U
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![BU of 3e8u by Molmil](/molmil-images/mine/3e8u) | Crystal structure and thermodynamic analysis of diagnostic Fab 106.3 complexed with BNP 5-13 (C10A) reveal basis of selective molecular recognition | 分子名称: | BNP peptide epitope, Fab 106.3 heavy chain, Fab 106.3 light chain | 著者 | Longenecker, K.L, Ruan, Q, Fry, E.H, Saldana, S.S, Brophy, S.E, Richardson, P.L, Tetin, S.Y. | 登録日 | 2008-08-20 | 公開日 | 2009-07-07 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure and thermodynamic analysis of diagnostic mAb 106.3 complexed with BNP 5-13 (C10A). Proteins, 76, 2009
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5LL2
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3E9G
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![BU of 3e9g by Molmil](/molmil-images/mine/3e9g) | Crystal structure long-form (residue1-124) of Eaf3 chromo domain | 分子名称: | Chromatin modification-related protein EAF3 | 著者 | Sun, B, Hong, J, Zhang, P, Lin, D, Ding, J. | 登録日 | 2008-08-22 | 公開日 | 2008-11-04 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Molecular Basis of the Interaction of Saccharomyces cerevisiae Eaf3 Chromo Domain with Methylated H3K36 J.Biol.Chem., 283, 2008
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2IU1
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3EDU
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![BU of 3edu by Molmil](/molmil-images/mine/3edu) | Crystal structure of the ankyrin-binding domain of human erythroid spectrin | 分子名称: | Spectrin beta chain, erythrocyte | 著者 | Simonovic, M, Stabach, P, Simonovic, I, Steitz, T.A, Morrow, J.S. | 登録日 | 2008-09-03 | 公開日 | 2009-02-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The structure of the ankyrin-binding site of {beta}-spectrin reveals how tandem spectrin-repeats generate unique ligand-binding properties Blood, 113, 2009
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3E63
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![BU of 3e63 by Molmil](/molmil-images/mine/3e63) | Fragment based discovery of JAK-2 inhibitors | 分子名称: | 5-phenyl-1H-indazol-3-amine, Tyrosine-protein kinase JAK2 | 著者 | Antonysamy, S, Fang, W, Hirst, G, Park, F, Russell, M, Smyth, L, Sprengeler, P, Stappenbeck, F, Steensma, R, Thompson, D.A, Wilson, M, Wong, M, Zhang, A, Zhang, F. | 登録日 | 2008-08-14 | 公開日 | 2008-10-14 | 最終更新日 | 2012-02-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Fragment-based discovery of JAK-2 inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
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5LIK
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![BU of 5lik by Molmil](/molmil-images/mine/5lik) | Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK181 | 分子名称: | 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Cousido-Siah, A, Ruiz, F.X, Mitschler, A, Fanfrlik, J, Kamlar, M, Vesely, J, Hobza, P, Podjarny, A. | 登録日 | 2016-07-14 | 公開日 | 2016-07-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors. Acs Chem.Biol., 11, 2016
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5LIY
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![BU of 5liy by Molmil](/molmil-images/mine/5liy) | Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK204 | 分子名称: | 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Cousido-Siah, A, Ruiz, F.X, Mitschler, A, Fanfrlik, J, Kamlar, M, Vesely, J, Hobza, P, Podjarny, A. | 登録日 | 2016-07-15 | 公開日 | 2016-10-12 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors. Acs Chem.Biol., 11, 2016
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9MSI
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![BU of 9msi by Molmil](/molmil-images/mine/9msi) | TYPE III ANTIFREEZE PROTEIN ISOFORM HPLC 12 T18N | 分子名称: | PROTEIN (ANTIFREEZE PROTEIN TYPE III) | 著者 | Graether, S.P, Deluca, C.I, Baardsnes, J, Hill, G.A, Davies, P.L, Jia, Z. | 登録日 | 1999-01-24 | 公開日 | 1999-04-28 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Quantitative and qualitative analysis of type III antifreeze protein structure and function. J.Biol.Chem., 274, 1999
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6ZAC
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![BU of 6zac by Molmil](/molmil-images/mine/6zac) | PI3K Delta in complex with [(dimethylamino)methyldihydrobenzoxazin2methoxypyridinyl]methanesulfonamide | 分子名称: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, ~{N}-[5-[6-[(dimethylamino)methyl]-2,3-dihydro-1,4-benzoxazin-4-yl]-2-methoxy-pyridin-3-yl]methanesulfonamide | 著者 | Convery, M.A, Hardy, C.J, Spencer, J.A, Rowland, P. | 登録日 | 2020-06-05 | 公開日 | 2020-07-01 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3-Kinase delta. Acs Med.Chem.Lett., 11, 2020
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5LJM
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![BU of 5ljm by Molmil](/molmil-images/mine/5ljm) | Structure of SPATA2 PUB domain | 分子名称: | GLYCEROL, Spermatogenesis-associated protein 2 | 著者 | Elliott, P.R, Komander, D. | 登録日 | 2016-07-18 | 公開日 | 2016-08-24 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.454 Å) | 主引用文献 | SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling. Mol.Cell, 63, 2016
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2IIH
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![BU of 2iih by Molmil](/molmil-images/mine/2iih) | Crystal structure of the molybdenum cofactor biosynthesis protein C (TTHA1789) from thermus theromophilus HB8 (H32 form) | 分子名称: | Molybdenum cofactor biosynthesis protein C, PHOSPHATE ION | 著者 | Jeyakanthan, J, Kanaujia, S.P, Vasuki Ranjani, C, Sekar, K, Baba, S, Chen, L, Liu, Z.-J, Wang, B.-C, Ebihara, A, Kuramitsu, S, Shinkai, A, Shiro, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2006-09-28 | 公開日 | 2007-10-09 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crystal structure of the molybdenum cofactor biosynthesis protein C (TTHA1789) from thermus theromophilus HB8 (H32 form) To be Published
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3EQ8
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![BU of 3eq8 by Molmil](/molmil-images/mine/3eq8) | Prolyl oligopeptidase complexed with R-Pro-(decarboxy-Pro)-Type inhibitors | 分子名称: | 1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one, Prolyl endopeptidase | 著者 | Kanai, K, Aranyi, P, Bocskei, Z, Ferenczy, G, Harmat, V, Simon, K, Naray-Szabo, G, Hermecz, I. | 登録日 | 2008-09-30 | 公開日 | 2009-08-25 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | 主引用文献 | Prolyl oligopeptidase inhibition by N-acyl-pro-pyrrolidine-type molecules J.Med.Chem., 51, 2008
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5LPX
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![BU of 5lpx by Molmil](/molmil-images/mine/5lpx) | Crystal structure of PKC phosphorylation-mimicking mutant (S26E) Annexin A2 | 分子名称: | Annexin A2, CALCIUM ION, GLYCEROL | 著者 | Ecsedi, P, Gogl, G, Kiss, B, Nyitray, L. | 登録日 | 2016-08-15 | 公開日 | 2017-07-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding. Structure, 25, 2017
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3E62
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![BU of 3e62 by Molmil](/molmil-images/mine/3e62) | Fragment based discovery of JAK-2 inhibitors | 分子名称: | 5-bromo-1H-indazol-3-amine, Tyrosine-protein kinase JAK2 | 著者 | Antonysamy, S, Fang, W, Hirst, G, Park, F, Russell, M, Smyth, L, Sprengeler, P, Stappenbeck, F, Steensma, R, Thompson, D.A, Wilson, M, Wong, M, Zhang, A, Zhang, F. | 登録日 | 2008-08-14 | 公開日 | 2008-10-14 | 最終更新日 | 2012-02-08 | 実験手法 | X-RAY DIFFRACTION (1.922 Å) | 主引用文献 | Fragment-based discovery of JAK-2 inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
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3EIE
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![BU of 3eie by Molmil](/molmil-images/mine/3eie) | Crystal Structure of S.cerevisiae Vps4 in the SO4-bound state | 分子名称: | SULFATE ION, Vacuolar protein sorting-associated protein 4 | 著者 | Gonciarz, M.D, Whitby, F.G, Eckert, D.M, Kieffer, C, Heroux, A, Sundquist, W.I, Hill, C.P. | 登録日 | 2008-09-15 | 公開日 | 2008-09-30 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Biochemical and structural studies of yeast vps4 oligomerization. J.Mol.Biol., 384, 2008
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4UWF
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![BU of 4uwf by Molmil](/molmil-images/mine/4uwf) | Discovery of (2S)-8-((3R)-3-Methylmorpholin-4-yl)-1-(3-methyl-2-oxo- butyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido(1,2-a)pyrimidin-6- one: a Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors | 分子名称: | (8S)-9-[3,5-bis(fluoranyl)phenyl]-2-morpholin-4-yl-8-(trifluoromethyl)-7,8-dihydro-6H-pyrimido[1,2-a]pyrimidin-4-one, PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3 | 著者 | Pasquier, B, El-Ahmad, Y, Filoche-Romme, B, Dureuil, C, Fassy, F, Abecassis, P.Y, Mathieu, M, Bertrand, T, Benard, T, Barriere, C, ElBatti, S, Letallec, J.P, Sonnefraud, V, Brollo, M, Delbarre, L, Loyau, V, Pilorge, F, Bertin, L, Richepin, P, Arigon, J, Labrosse, J.R, Clement, J, Durand, F, Combet, R, Perraut, P, Leroy, V, Gay, F, Lefrancois, D, Bretin, F, Marquette, J.P, Michot, N, Caron, A, Castell, C, Schio, L, McCort, G, Goulaouic, H, Garcia-Echeverria, C, Ronan, B. | 登録日 | 2014-08-12 | 公開日 | 2014-11-26 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-Yl]-1-(3-Methyl-2-Oxobutyl)-2-(Trifluoromethyl)-3,4-Dihydro-2H-Pyrimido[1,2-A]Pyrimidin-6-One: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors. J.Med.Chem., 58, 2015
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