6ZAC
PI3K Delta in complex with [(dimethylamino)methyldihydrobenzoxazin2methoxypyridinyl]methanesulfonamide
Summary for 6ZAC
Entry DOI | 10.2210/pdb6zac/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, ~{N}-[5-[6-[(dimethylamino)methyl]-2,3-dihydro-1,4-benzoxazin-4-yl]-2-methoxy-pyridin-3-yl]methanesulfonamide (3 entities in total) |
Functional Keywords | macrocycle, pi3k delta, thermodynamics, transferase |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 1 |
Total formula weight | 108216.14 |
Authors | Convery, M.A.,Hardy, C.J.,Spencer, J.A.,Rowland, P. (deposition date: 2020-06-05, release date: 2020-07-01, Last modification date: 2024-06-19) |
Primary citation | Spencer, J.A.,Baldwin, I.R.,Barton, N.,Chung, C.W.,Convery, M.A.,Edwards, C.D.,Jamieson, C.,Mallett, D.N.,Rowedder, J.E.,Rowland, P.,Thomas, D.A.,Hardy, C.J. Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3-Kinase delta. Acs Med.Chem.Lett., 11:1386-1391, 2020 Cited by PubMed: 32676144DOI: 10.1021/acsmedchemlett.0c00061 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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