3EQ8

Prolyl oligopeptidase complexed with R-Pro-(decarboxy-Pro)-Type inhibitors

Summary for 3EQ8

Entry DOI	10.2210/pdb3eq8/pdb
Related	3EQ7 3EQ9
Descriptor	Prolyl endopeptidase, 1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one (3 entities in total)
Functional Keywords	hydrolase, protease, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Sus scrofa (pig)
Cellular location	Cytoplasm: P23687
Total number of polymer chains	1
Total formula weight	81308.87
Authors	Kanai, K.,Aranyi, P.,Bocskei, Z.,Ferenczy, G.,Harmat, V.,Simon, K.,Naray-Szabo, G.,Hermecz, I. (deposition date: 2008-09-30, release date: 2009-08-25, Last modification date: 2023-11-01)
Primary citation	Kanai, K.,Aranyi, P.,Bocskei, Z.,Ferenczy, G.,Harmat, V.,Simon, K.,Batori, S.,Naray-Szabo, G.,Hermecz, I. Prolyl oligopeptidase inhibition by N-acyl-pro-pyrrolidine-type molecules J.Med.Chem., 51:7514-7522, 2008 Cited by PubMed: 19006380 DOI: 10.1021/jm800944x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.73 Å)

Structure validation