3EQ7
Prolyl oligopeptidase complexed with R-Pro-(decarboxy-Pro)-Type inhibitors
Summary for 3EQ7
Entry DOI | 10.2210/pdb3eq7/pdb |
Related | 3EQ8 3EQ9 |
Descriptor | Prolyl endopeptidase, 2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dione (3 entities in total) |
Functional Keywords | protease-inhibitor complex, hydrolase, protease, serine protease |
Biological source | Sus scrofa (pig) |
Cellular location | Cytoplasm: P23687 |
Total number of polymer chains | 1 |
Total formula weight | 81269.74 |
Authors | Kanai, K.,Aranyi, P.,Bocskei, Z.,Ferenczy, G.,Harmat, V.,Simon, K.,Naray-Szabo, G.,Hermecz, I. (deposition date: 2008-09-30, release date: 2009-08-25, Last modification date: 2023-11-01) |
Primary citation | Kanai, K.,Aranyi, P.,Bocskei, Z.,Ferenczy, G.,Harmat, V.,Simon, K.,Batori, S.,Naray-Szabo, G.,Hermecz, I. Prolyl oligopeptidase inhibition by N-acyl-pro-pyrrolidine-type molecules J.Med.Chem., 51:7514-7522, 2008 Cited by PubMed: 19006380DOI: 10.1021/jm800944x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.89 Å) |
Structure validation
Download full validation report