3PS1
| Crystal structure of the Escherichia Coli LPXC/LPC-011 complex | 分子名称: | 4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]benzamide, 4-ethynyl-N-[(1S,2R)-2-hydroxy-1-(oxocarbamoyl)propyl]benzamide, DIMETHYL SULFOXIDE, ... | 著者 | Lee, C.-J, Zhou, P. | 登録日 | 2010-11-30 | 公開日 | 2011-01-19 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold. Bioorg.Med.Chem., 19, 2011
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3PM8
| CAD domain of PFF0520w, Calcium dependent protein kinase | 分子名称: | CALCIUM ION, CHLORIDE ION, Calcium-dependent protein kinase 2, ... | 著者 | Wernimont, A.K, Hutchinson, A, Lew, J, Chamberlain, K, MacKenzie, F, Loppnau, P, Cossar, D, Crombet, L, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Hui, R, Amani, M, Structural Genomics Consortium (SGC) | 登録日 | 2010-11-16 | 公開日 | 2010-12-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | CAD domain of PFF0520w, Calcium dependent protein kinase TO BE PUBLISHED
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8OVN
| X-ray structure of the SF-iGluSnFR-S72A | 分子名称: | CITRIC ACID, Putative periplasmic binding transport protein,Green fluorescent protein | 著者 | Tarnawski, M, Hellweg, L, Bergner, A, Hiblot, J, Leippe, P, Johnsson, K. | 登録日 | 2023-04-26 | 公開日 | 2023-05-17 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | X-ray structure of the SF-iGluSnFR-S72A To Be Published
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8OVO
| X-ray structure of the SF-iGluSnFR-S72A in complex with L-aspartate | 分子名称: | ASPARTIC ACID, Putative periplasmic binding transport protein,Green fluorescent protein | 著者 | Tarnawski, M, Hellweg, L, Bergner, A, Hiblot, J, Leippe, P, Johnsson, K. | 登録日 | 2023-04-26 | 公開日 | 2023-05-17 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | X-ray structure of the SF-iGluSnFR-S72A in complex with L-aspartate To Be Published
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8OVP
| X-ray structure of the iAspSnFR in complex with L-aspartate | 分子名称: | ACETATE ION, ASPARTIC ACID, MAGNESIUM ION, ... | 著者 | Tarnawski, M, Hellweg, L, Bergner, A, Hiblot, J, Leippe, P, Johnsson, K. | 登録日 | 2023-04-26 | 公開日 | 2023-05-17 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | X-ray structure of the SF-iAspSnFR in complex with L-aspartate To Be Published
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5LAL
| Structure of Arabidopsis dirigent protein AtDIR6 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dirigent protein 6, ... | 著者 | Gasper, R, Kolesinski, P, Terlecka, B, Effenberger, I, Schaller, A, Hofmann, E. | 登録日 | 2016-06-14 | 公開日 | 2016-11-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Dirigent Protein Mode of Action Revealed by the Crystal Structure of AtDIR6. Plant Physiol., 172, 2016
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3PSV
| Structure of E97D mutant of TIM from Plasmodium falciparum | 分子名称: | 1,2-ETHANEDIOL, SULFATE ION, Triosephosphate isomerase | 著者 | Samanta, M, Murthy, M.R.N, Balaram, H, Balaram, P. | 登録日 | 2010-12-02 | 公開日 | 2011-10-19 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Revisiting the mechanism of the triosephosphate isomerase reaction: the role of the fully conserved glutamic acid 97 residue Chembiochem, 12, 2011
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2V60
| Structure of human MAO B in complex with the selective inhibitor 7-(3- chlorobenzyloxy)-4-carboxaldehyde-coumarin | 分子名称: | 7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE, AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Binda, C, Wang, J, Pisani, L, Caccia, C, Carotti, A, Salvati, P, Edmondson, D.E, Mattevi, A. | 登録日 | 2007-07-12 | 公開日 | 2007-10-16 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs. J.Med.Chem., 50, 2007
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5N63
| Crystal Structure of p38alpha in Complex with Lipid Pocket Ligand 9c | 分子名称: | Mitogen-activated protein kinase 14, ~{N}4-[(4-fluorophenyl)methyl]-2-phenyl-quinazoline-4,7-diamine | 著者 | Buehrmann, M, Mueller, M.P, Rauh, D. | 登録日 | 2017-02-14 | 公開日 | 2017-09-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38 alpha MAPK. PLoS ONE, 12, 2017
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2VBD
| Isopenicillin N synthase with substrate analogue L,L,L-ACOMP (unexposed) | 分子名称: | FE (II) ION, ISOPENICILLIN N SYNTHETASE, N^6^-[(1R)-2-[(1R)-1-carboxy-2-(methylsulfanyl)ethoxy]-2-oxo-1-(sulfanylmethyl)ethyl]-6-oxo-L-lysine | 著者 | Ge, W, Clifton, I.J, Adlington, R.M, Baldwin, J.E, Rutledge, P.J. | 登録日 | 2007-09-10 | 公開日 | 2008-09-23 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Crystal Structure of an Lll-Configured Depsipeptide Substrate Analogue Bound to Isopenicillin N Synthase. Org.Biomol.Chem., 8, 2010
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5KMG
| Near-atomic cryo-EM structure of PRC1 bound to the microtubule | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Kellogg, E.H, Howes, S, Ti, S.-C, Ramirez-Aportela, E, Kapoor, T.M, Chacon, P, Nogales, E. | 登録日 | 2016-06-27 | 公開日 | 2016-08-03 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Near-atomic cryo-EM structure of PRC1 bound to the microtubule. Proc.Natl.Acad.Sci.USA, 113, 2016
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8W1N
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2VIF
| Crystal structure of SOCS6 SH2 domain in complex with a c-KIT phosphopeptide | 分子名称: | 1,2-ETHANEDIOL, MAST/STEM CELL GROWTH FACTOR RECEPTOR, SUPPRESSOR OF CYTOKINE SIGNALLING 6 | 著者 | Bullock, A, Pike, A.C.W, Savitsky, P, Keates, T, Pilka, E.S, von Delft, F, Edwards, A, Weigelt, J, Arrowsmith, C.H, Knapp, S. | 登録日 | 2007-11-30 | 公開日 | 2007-12-25 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structural Basis for C-Kit Inhibition by the Suppressor of Cytokine Signaling 6 (Socs6) Ubiquitin Ligase. J.Biol.Chem., 286, 2011
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2V62
| Structure of vaccinia-related kinase 2 | 分子名称: | 1,2-ETHANEDIOL, MAGNESIUM ION, SERINE/THREONINE-PROTEIN KINASE VRK2, ... | 著者 | Bunkoczi, G, Eswaran, J, Cooper, C, Fedorov, O, Keates, T, Rellos, P, Salah, E, Savitsky, P, Ugochukwu, E, von Delft, F, Arrowsmith, C.H, Edwards, A, Sundstrom, M, Weigelt, J, Knapp, S. | 登録日 | 2007-07-13 | 公開日 | 2007-08-21 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure of the Pseudokinase Vrk3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site. Structure, 17, 2009
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2V61
| Structure of human MAO B in complex with the selective inhibitor 7-(3- chlorobenzyloxy)-4-(methylamino)methyl-coumarin | 分子名称: | 7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE, AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Binda, C, Wang, J, Pisani, L, Caccia, C, Carotti, A, Salvati, P, Edmondson, D.E, Mattevi, A. | 登録日 | 2007-07-13 | 公開日 | 2007-10-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs. J.Med.Chem., 50, 2007
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8W5J
| Cryo-EM structure of the yeast TOM core complex (from TOM-TIM23 complex) | 分子名称: | (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl tetradecanoate, Mitochondrial import receptor subunit TOM22, Mitochondrial import receptor subunit TOM40, ... | 著者 | Wang, Q, Guan, Z.Y, Zhuang, J.J, Huang, R, Yin, P. | 登録日 | 2023-08-27 | 公開日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | The architecture of substrate-engaged TOM-TIM23 supercomplex reveals preprotein proximity sites for mitochondrial protein translocation. Cell Discov, 10, 2024
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2VBP
| Isopenicillin N synthase with substrate analogue L,L,L-ACAB (unexposed) | 分子名称: | FE (II) ION, ISOPENICILLIN N SYNTHETASE, N^6^-[(1R)-2-{[(1S)-1-carboxypropyl]amino}-2-oxo-1-(sulfanylmethyl)ethyl]-6-oxo-L-lysine, ... | 著者 | Ge, W, Clifton, I.J, Adlington, R.M, Baldwin, J.E, Rutledge, P.J. | 登録日 | 2007-09-14 | 公開日 | 2008-11-04 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystallographic Studies on the Binding of Selectively Deuterated Lld- and Lll-Substrate Epimers by Isopenicillin N Synthase. Biochem.Biophys.Res.Commun., 398, 2010
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2VFA
| Crystal structure of a chimera of Plasmodium falciparum and human hypoxanthine-guanine phosphoribosyl transferases | 分子名称: | GUANOSINE-5'-MONOPHOSPHATE, HYPOXANTHINE-GUANINE-XANTHINE PHOSPHORIBOSYLTRANSFERASE, HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, ... | 著者 | Gayathri, P, Selvi, T.S, Subbayya, I.N.S, Ashok, C.S, Balaram, H, Murthy, M.R.N. | 登録日 | 2007-11-02 | 公開日 | 2008-06-17 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal Structure of a Chimera of Human and Plasmodium Falciparum Hypoxanthine Guanine Phosphoribosyltransferases Provides Insights Into Oligomerization. Proteins, 73, 2008
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5NB1
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2V3U
| Structure of the ligand-binding core of the ionotropic glutamate receptor-like GluRdelta2 in complex with D-serine | 分子名称: | CHLORIDE ION, D-SERINE, GLUTAMATE RECEPTOR DELTA-2 SUBUNIT, ... | 著者 | Naur, P, Vestergaard, B, Gajhede, M, Kastrup, J.S. | 登録日 | 2007-06-22 | 公開日 | 2007-08-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Ionotropic Glutamate-Like Receptor {Delta}2 Binds D-Serine and Glycine. Proc.Natl.Acad.Sci.USA, 104, 2007
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7VZF
| Cryo-EM structure of amyloid fibril formed by full-length human SOD1 | 分子名称: | Superoxide dismutase [Cu-Zn] | 著者 | Wang, L.Q, Ma, Y.Y, Yuan, H.Y, Zhao, K, Zhang, M.Y, Wang, Q, Huang, X, Xu, W.C, Chen, J, Li, D, Zhang, D.L, Zou, L.Y, Yin, P, Liu, C, Liang, Y. | 登録日 | 2021-11-16 | 公開日 | 2022-06-29 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion. Nat Commun, 13, 2022
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6TA0
| Human NAMPT in complex with nicotinic acid and phosphoribosyl pyrophosphate | 分子名称: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, GLYCEROL, NICOTINIC ACID, ... | 著者 | Houry, D, Raasakka, A, Kursula, P, Ziegler, M. | 登録日 | 2019-10-29 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Identification of structural determinants of NAMPT activity and substrate selectivity To Be Published
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2Y0J
| Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors, part 2, Lead-optimisation. | 分子名称: | 5-(1H-BENZIMIDAZOL-2-YLMETHYLSULFANYL)-2-METHYL-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLINE, CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE 10A, ... | 著者 | Kehler, J, Ritzen, A, Langgard, M, Petersen, S.L, Christoffersen, C.T, Nielsen, J, Kilburn, J.P. | 登録日 | 2010-12-03 | 公開日 | 2011-06-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Triazoloquinazolines as a Novel Class of Phosphodiesterase 10A (Pde10A) Inhibitors. Bioorg.Med.Chem.Lett., 21, 2011
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2Y1L
| Caspase-8 in Complex with DARPin-8.4 | 分子名称: | 1,2-ETHANEDIOL, AC-IETD-CHO, Caspase-8, ... | 著者 | Barandun, J, Schroeder, T, Mittl, P.R.E, Grutter, M.G. | 登録日 | 2010-12-08 | 公開日 | 2011-12-28 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Caspase-8 in Complex with Darpin-8.4 To be Published
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2Y62
| Crystal structure of Leishmanial E65Q-TIM complexed with R-Glycidol phosphate | 分子名称: | GLYCEROL, SN-GLYCEROL-1-PHOSPHATE, SN-GLYCEROL-3-PHOSPHATE, ... | 著者 | Venkatesan, R, Alahuhta, M, Pihko, P.M, Wierenga, R.K. | 登録日 | 2011-01-19 | 公開日 | 2011-12-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | 主引用文献 | High Resolution Crystal Structures of Triosephosphate Isomerase Complexed with its Suicide Inhibitors: The Conformational Flexibility of the Catalytic Glutamate in its Closed, Liganded Active Site. Protein Sci., 20, 2011
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