8TOP
| Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with antibody GPZ6-b.01 targeting the fusion peptide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 BG505 DS-SOSIP glycoprotein gp41, ... | 著者 | Zhou, T, Morano, N.C, Roark, R.S, Kwong, P.D. | 登録日 | 2023-08-03 | 公開日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | 主引用文献 | Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with antibody GPZ6-b.01 targeting the fusion peptide To Be Published
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3ONJ
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5MVC
| Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds | 分子名称: | 4-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]-1,2,5-thiadiazole-3-carboxamide, ACETATE ION, CHLORIDE ION, ... | 著者 | Goyal, P, Andersson, M, Moritzer, A.C, Sainas, S, Pippione, A.C, Boschi, D, Al-Kadaraghi, S, Lolli, M, Friemann, R. | 登録日 | 2017-01-16 | 公開日 | 2017-03-08 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds. Eur J Med Chem, 129, 2017
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2W4B
| Epstein-Barr virus alkaline nuclease D203S mutant | 分子名称: | ALKALINE EXONUCLEASE | 著者 | Buisson, M, Geoui, T, Flot, D, Tarbouriech, N, Burmeister, W.P. | 登録日 | 2008-11-24 | 公開日 | 2009-06-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | A Bridge Crosses the Active Site Canyon of the Epstein-Barr Virus Nuclease with DNase and Rnase Activity. J.Mol.Biol., 391, 2009
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8TO7
| Cryo-EM structure of HERH-b*01 Fab in complex with HIV-1 Env trimer BG505.DS SOSIP | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HERH-b*01 heavy chain, ... | 著者 | Roark, R.S, Hoyt, F, Hansen, B, Fischer, E, Shapiro, L.S, Kwong, P.D. | 登録日 | 2023-08-03 | 公開日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Broad and potent HIV-1 neutralization in fusion peptide-primed SHIV-boosted macaques To Be Published
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3P5N
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8TO9
| Cryo-EM structure of TRNM-f*01 Fab in complex with HIV-1 Env trimer ConC SOSIP | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | 著者 | Roark, R.S, Morano, N.C, Shapiro, L.S, Kwong, P.D. | 登録日 | 2023-08-03 | 公開日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (4.03 Å) | 主引用文献 | Broad and potent HIV-1 neutralization in fusion peptide-primed SHIV-boosted macaques To Be Published
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2W1I
| Structure determination of Aurora Kinase in complex with inhibitor | 分子名称: | 4-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-1H-BENZIMIDAZOL-6-YL)METHYL]MORPHOLIN-4-IUM, JAK2 | 著者 | Howard, S, Berdini, V, Boulstridge, J.A, Carr, M.G, Cross, D.M, Curry, J, Devine, L.A, Early, T.R, Fazal, L, Gill, A.L, Heathcote, M, Maman, S, Matthews, J.E, McMenamin, R.L, Navarro, E.F, O'Brien, M.A, O'Reilly, M, Rees, D.C, Reule, M, Tisi, D, Williams, G, Vinkovic, M, Wyatt, P.G. | 登録日 | 2008-10-17 | 公開日 | 2009-01-27 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Fragment-Based Discovery of the Pyrazol-4-Yl Urea (at9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity. J.Med.Chem., 52, 2009
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7XLY
| Crystal structure of FadA2 (Rv0243) from the fatty acid metabolic pathway of Mycobacterium tuberculosis | 分子名称: | Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (Beta-ketothiolase), SULFATE ION | 著者 | Singh, R, Kundu, P, Singh, B.K, Bhattacharyya, S, Das, A.K. | 登録日 | 2022-04-23 | 公開日 | 2023-04-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structure of FadA2 thiolase from Mycobacterium tuberculosis and prediction of its substrate specificity and membrane-anchoring properties. Febs J., 290, 2023
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2W7W
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2WA7
| Structure of the M202V mutant of human filamin b actin binding domain at 1.85 Angstrom resolution | 分子名称: | CACODYLATE ION, CARBONATE ION, FILAMIN-B | 著者 | Sawyer, G.M, Clark, A.R, Robertson, S.P, Sutherland-Smith, A.J. | 登録日 | 2009-02-03 | 公開日 | 2009-06-23 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Disease-Associated Substitutions in the Filamin B Actin Binding Domain Confer Enhanced Actin Binding Affinity in the Absence of Major Structural Disturbance: Insights from the Crystal Structures of Filamin B Actin Binding Domains. J.Mol.Biol., 390, 2009
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8TK4
| HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with phosphate | 分子名称: | Dual specificity protein phosphatase 3, PHOSPHATE ION | 著者 | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | 登録日 | 2023-07-25 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with phosphate To Be Published
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3P9C
| Crystal structure of perennial ryegrass LpOMT1 bound to SAH | 分子名称: | (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 1,2-ETHANEDIOL, ACETATE ION, ... | 著者 | Louie, G.V, Noel, J.P, Bowman, M.E. | 登録日 | 2010-10-17 | 公開日 | 2011-01-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure-Function Analyses of a Caffeic Acid O-Methyltransferase from Perennial Ryegrass Reveal the Molecular Basis for Substrate Preference. Plant Cell, 22, 2010
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8TOX
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2WAS
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8TGW
| Cryo-EM structure of 1059 SOSIP trimer purified via Galanthus nivalis lectin chromatography | 分子名称: | 1059 SOSIP Surface protein gp120, 1059 SOSIP Transmembrane protein gp41, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Parsons, R.J, Pothula, K, Acharya, P. | 登録日 | 2023-07-13 | 公開日 | 2024-08-28 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted/founder sensitivity to broadly neutralizing antibodies. Nat Commun, 15, 2024
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2WFW
| Structure and activity of the N-terminal substrate recognition domains in proteasomal ATPases - The Arc domain structure | 分子名称: | ARC | 著者 | Djuranovic, S, Hartmann, M.D, Habeck, M, Ursinus, A, Zwickl, P, Martin, J, Lupas, A.N, Zeth, K. | 登録日 | 2009-04-15 | 公開日 | 2009-05-12 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure and Activity of the N-Terminal Substrate Recognition Domains in Proteasomal Atpases. Mol.Cell, 34, 2009
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3OHW
| X-Ray Structure of Phycobilisome LCM core-membrane linker polypeptide (fragment 721-860) from Synechocystis sp. PCC 6803, Northeast Structural Genomics Consortium Target SgR209E | 分子名称: | Phycobilisome LCM core-membrane linker polypeptide | 著者 | Kuzin, A, Su, M, Lew, S, Vorobiev, S.M, Patel, P, Xiao, R, Ciccosanti, C, Lee, D, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2010-08-18 | 公開日 | 2010-09-01 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Northeast Structural Genomics Consortium Target SgR209E To be Published
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5JR8
| Disposal of Iron by a Mutant form of Siderocalin NGAL | 分子名称: | GLYCEROL, Neutrophil gelatinase-associated lipocalin, PHOSPHATE ION | 著者 | Rupert, P.B, Strong, R.K, Barasch, J, Hollman, M, Deng, R, Hod, E.A, Abergel, R, Allred, B, Xu, K, Darrah, S, Tekabe, Y, Perlstein, A, Bruck, E, Stauber, J, Corbin, K, Buchen, C, Slavkovich, V, Graziano, J, Spitalnik, S, Qiu, A. | 登録日 | 2016-05-05 | 公開日 | 2016-09-28 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Disposal of iron by a mutant form of lipocalin 2. Nat Commun, 7, 2016
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8TGU
| Cryo-EM structure of BG505 SOSIP trimer purified via Galanthus nivalis lectin chromatography | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 Envelope glycoprotein BG505 SOSIP, ... | 著者 | Parsons, R.J, Pothula, K, Acharya, P. | 登録日 | 2023-07-13 | 公開日 | 2024-08-28 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted/founder sensitivity to broadly neutralizing antibodies. Nat Commun, 15, 2024
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6SZ8
| Crystal structure of YTHDC1 with fragment 6 (DHU_DC1_034) | 分子名称: | 6-pyrrolidin-1-yl-5~{H}-pyrimidine-2,4-dione, SULFATE ION, YTH domain-containing protein 1 | 著者 | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | 登録日 | 2019-10-02 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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2VQX
| Precursor of Protealysin, Metalloproteinase from Serratia proteamaculans. | 分子名称: | METALLOPROTEINASE, ZINC ION | 著者 | Melik-Adamyan, W.R, Kuranova, I.P, Polyakov, K.M, Demidyuk, I.V, Gromova, T.Y, Kostrov, S.V. | 登録日 | 2008-03-20 | 公開日 | 2009-05-26 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.821 Å) | 主引用文献 | Crystal Structure of the Protealysin Precursor: Insights Into Propeptide Function. J.Biol.Chem., 285, 2010
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6SZN
| Crystal structure of YTHDC1 with fragment 8 (DHU_DC1_006) | 分子名称: | N-carbamoylbenzamide, SULFATE ION, YTH domain-containing protein 1 | 著者 | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | 登録日 | 2019-10-02 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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6WVT
| Structural basis of alphaE-catenin - F-actin catch bond behavior | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Xu, X.P, Pokutta, S, Torres, M, Swift, M.F, Hanein, D, Volkmann, N, Weis, W.I. | 登録日 | 2020-05-06 | 公開日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | 主引用文献 | Structural basis of alpha E-catenin-F-actin catch bond behavior. Elife, 9, 2020
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3OMU
| Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of a thienopyrimidine derivative | 分子名称: | 2-amino-4-{2,4-dichloro-5-[2-(diethylamino)ethoxy]phenyl}-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide, Heat shock protein 83 | 著者 | Wernimont, A.K, Hutchinson, A, Sullivan, H, Weadge, J, Cossar, D, Li, Y, Kozieradzki, I, Bochkarev, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Wyatt, P.G, Fairlamb, A.H, MacKenzie, C, Ferguson, M.A.J, Hui, R, Pizarro, J.C, Hills, T, Structural Genomics Consortium (SGC) | 登録日 | 2010-08-27 | 公開日 | 2010-10-27 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design. PLoS Negl Trop Dis, 7, 2013
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