7R91
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7r91 by Molmil](/molmil-images/mine/7r91) | cryo-EM structure of the rigor state wild type myosin-15-F-actin complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Gong, R, Reynolds, M.J, Gurel, P, Alushin, G.M. | 登録日 | 2021-06-28 | 公開日 | 2021-07-28 | 最終更新日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia. Sci Adv, 8, 2022
|
|
7RB9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rb9 by Molmil](/molmil-images/mine/7rb9) | Cryo-EM structure of the rigor state Jordan myosin-15-F-actin complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Gong, R, Reynolds, M.J, Gurel, P, Alushin, G.M. | 登録日 | 2021-07-05 | 公開日 | 2021-07-28 | 最終更新日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (3.76 Å) | 主引用文献 | Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia. Sci Adv, 8, 2022
|
|
7RB8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rb8 by Molmil](/molmil-images/mine/7rb8) | cryo-EM structure of the ADP state wild type myosin-15-F-actin complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Gong, R, Reynolds, M.J, Gurel, P, Alushin, G.M. | 登録日 | 2021-07-05 | 公開日 | 2021-07-28 | 最終更新日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | 主引用文献 | Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia. Sci Adv, 8, 2022
|
|
2XYE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2xye by Molmil](/molmil-images/mine/2xye) | HIV-1 Inhibitors with a Tertiary-Alcohol-containing Transition-State Mimic and various P2 and P1 prime Substituents | 分子名称: | METHYL N-[(2S)-1-[2-[(4R)-5-[[(2S)-3,3-DIMETHYL-1-METHYLAMINO-1-OXO-BUTAN-2-YL]AMINO]-4-HYDROXY-5-OXO-4-(PHENYLMETHYL)PENTYL]-2-[(4-PHENYLPHENYL)METHYL]HYDRAZINYL]-3,3-DIMETHYL-1-OXO-BUTAN-2-YL]CARBAMATE, PROTEASE | 著者 | Ohrngren, P, Wu, X, Persson, M, Ekegren, J.K, Wallberg, H, Rosenquist, A, Samuelsson, B, Unge, T, Larhed, M. | 登録日 | 2010-11-17 | 公開日 | 2011-12-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | HIV-1 Protease Inhibitors with a Tertiary Alcohol Containing Transition-State Mimic and Various P2 and P1' Substituents Med.Chem.Commun., 2, 2011
|
|
7RJ1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rj1 by Molmil](/molmil-images/mine/7rj1) | Crystal structure of Aro7p chorismate mutase from Candida albicans, complex with L-Trp | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Chorismate mutase, ... | 著者 | Stogios, P.J, Evdokimova, E, Tan, K, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2021-07-20 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | Crystal structure of Aro7p chorismate mutase from Candida albicans, complex with L-Trp To Be Published
|
|
2Y3Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2y3z by Molmil](/molmil-images/mine/2y3z) | Structure of Isopropylmalate dehydrogenase from Thermus thermophilus - apo enzyme | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-ISOPROPYLMALATE DEHYDROGENASE, GLYCEROL, ... | 著者 | Graczer, E, merlin, A, Singh, R.K, Manikandan, K, Zavodsky, P, Weiss, M.S, Vas, M. | 登録日 | 2011-01-04 | 公開日 | 2011-01-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Atomic Level Description of the Domain Closure in a Dimeric Enzyme: Thermus Thermophilus 3-Isopropylmalate Dehydrogenase. Mol.Biosyst., 7, 2011
|
|
4FBN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4fbn by Molmil](/molmil-images/mine/4fbn) | Insights into structural integration of the PLCgamma regulatory region and mechanism of autoinhibition and activation based on key roles of SH2 domains | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 著者 | Cole, A.R, Mas-Droux, C.P, Bunney, T.D, Katan, M. | 登録日 | 2012-05-23 | 公開日 | 2012-10-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation. Structure, 20, 2012
|
|
1M3V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1m3v by Molmil](/molmil-images/mine/1m3v) | FLIN4: Fusion of the LIM binding domain of Ldb1 and the N-terminal LIM domain of LMO4 | 分子名称: | ZINC ION, fusion of the LIM interacting domain of ldb1 and the N-terminal LIM domain of LMO4 | 著者 | Deane, J.E, Mackay, J.P, Kwan, A.H.Y, Sum, E.Y, Visvader, J.E, Matthews, J.M. | 登録日 | 2002-06-30 | 公開日 | 2003-05-13 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4 EMBO J., 22, 2003
|
|
2Y40
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2y40 by Molmil](/molmil-images/mine/2y40) | Structure of Isopropylmalate dehydrogenase from Thermus thermophilus - complex with Mn | 分子名称: | 3-ISOPROPYLMALATE DEHYDROGENASE, MANGANESE (II) ION | 著者 | Graczer, E, merlin, A, Singh, R.K, Manikandan, K, Zavodsky, P, Weiss, M.S, Vas, M. | 登録日 | 2011-01-04 | 公開日 | 2011-01-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Atomic Level Description of the Domain Closure in a Dimeric Enzyme: Thermus Thermophilus 3-Isopropylmalate Dehydrogenase. Mol.Biosyst., 7, 2011
|
|
7XRS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7xrs by Molmil](/molmil-images/mine/7xrs) | Crystal structure of SARS-Cov-2 main protease in complex with inhibitor YH-53 | 分子名称: | N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-methoxy-1H-indole-2-carboxamide, Replicase polyprotein 1a | 著者 | Zhou, X.L, Zhong, F.L, Lin, C, Zeng, P, Zhang, J, Li, J. | 登録日 | 2022-05-11 | 公開日 | 2022-12-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor. Viruses, 14, 2022
|
|
2Y0D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2y0d by Molmil](/molmil-images/mine/2y0d) | BceC mutation Y10K | 分子名称: | SULFATE ION, UDP-GLUCOSE DEHYDROGENASE, URIDINE-5'-DIPHOSPHATE-GLUCURONIC ACID | 著者 | Rocha, J, Popescu, A.O, Borges, P, Mil-Homens, D, Sa-Correia, I, Fialho, A.M, Frazao, C. | 登録日 | 2010-12-02 | 公開日 | 2011-07-27 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure of Burkholderia Cepacia Udp-Glucose Dehydrogenase (Ugd) Bcec and Role of Tyr10 in Final Hydrolysis of Ugd Thioester Intermediate. J.Bacteriol., 193, 2011
|
|
2Y1X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2y1x by Molmil](/molmil-images/mine/2y1x) | CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR | 分子名称: | CHLORIDE ION, HISTONE-ARGININE METHYLTRANSFERASE CARM1, N-(3-{5-[5-(1H-INDOL-4-YL)-1,3,4-OXADIAZOL-2-YL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL}BENZYL)-L-ALANINAMIDE, ... | 著者 | Sack, J.S, Thieffine, S, Bandiera, T, Fasolini, M, Duke, G.J, Jayaraman, L, Kish, K.F, Klei, H.E, Purandare, A.V, Rosettani, P, Troiani, S, Xie, D, Bertrand, J.A. | 登録日 | 2010-12-10 | 公開日 | 2011-03-23 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural Basis for Carm1 Inhibition by Indole and Pyrazole Inhibitors Biochem.J., 436, 2011
|
|
4FAJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4faj by Molmil](/molmil-images/mine/4faj) | Structure and mode of peptide binding of pheromone receptor PrgZ | 分子名称: | GLYCEROL, PrgZ, Sex pheromone cCF10, ... | 著者 | Berntsson, R.P.-A, Schuurman-Wolters, G.K, Dunny, K, Slotboom, D.J, Poolman, B. | 登録日 | 2012-05-22 | 公開日 | 2012-09-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure and Mode of Peptide Binding of Pheromone Receptor PrgZ. J.Biol.Chem., 287, 2012
|
|
1MYR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1myr by Molmil](/molmil-images/mine/1myr) | MYROSINASE FROM SINAPIS ALBA | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | 著者 | Burmeister, W.P, Iori, R, Palmieri, S, Henrissat, B. | 登録日 | 1997-03-23 | 公開日 | 1997-06-16 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | The crystal structures of Sinapis alba myrosinase and a covalent glycosyl-enzyme intermediate provide insights into the substrate recognition and active-site machinery of an S-glycosidase. Structure, 5, 1997
|
|
4FFV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ffv by Molmil](/molmil-images/mine/4ffv) | Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with 11A19 Fab | 分子名称: | 11A19 Fab heavy chain, 11A19 Fab light chain, Dipeptidyl peptidase 4 | 著者 | Wang, Z, Sudom, A, Walker, N.P, Min, X. | 登録日 | 2012-06-01 | 公開日 | 2012-12-12 | 最終更新日 | 2021-05-19 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | An Inhibitory Antibody Against DPP IV Improves Glucose Tolerance in vivo - Validation of Large Molecule Approach for DPP IV Inhibition To be published
|
|
2Y6E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2y6e by Molmil](/molmil-images/mine/2y6e) | Structure of the D1D2 domain of USP4, the conserved catalytic domain | 分子名称: | SULFATE ION, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4, ZINC ION | 著者 | Luna-Vargas, M.P.A, Faesen, A.C, van Dijk, W.J, Rape, M, Fish, A, Sixma, T.K. | 登録日 | 2011-01-20 | 公開日 | 2011-04-06 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The Dusp-Ubl Domain of Usp4 Enhances its Catalytic Efficiency by Promoting Ubiquitin Exchange. Nat.Commun., 5, 2014
|
|
2YFI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2yfi by Molmil](/molmil-images/mine/2yfi) | |
2YOF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2yof by Molmil](/molmil-images/mine/2yof) | Plasmodium falciparum thymidylate kinase in complex with a (thio)urea- beta-deoxythymidine inhibitor | 分子名称: | 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-[[(2R,3S)-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methyl]thiourea, ACETATE ION, THYMIDYLATE KINASE, ... | 著者 | Huaqing, C, Carrero-Lerida, J, Silva, A.P.G, Whittingham, J.L, Brannigan, J.A, Ruiz-Perez, L.M, Read, K.D, Wilson, K.S, Gonzalez-Pacanowska, D, Gilbert, I.H. | 登録日 | 2012-10-24 | 公開日 | 2013-07-24 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Synthesis and Evaluation of Alpha-Thymidine Analogues as Novel Antimalarials. J.Med.Chem., 55, 2012
|
|
1MZI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1mzi by Molmil](/molmil-images/mine/1mzi) | Solution ensemble structures of HIV-1 gp41 2F5 mAb epitope | 分子名称: | 2F5 epitope of HIV-1 gp41 fusion protein | 著者 | Barbato, G, Bianchi, E, Ingallinella, P, Hurni, W.H, Miller, M.D, Ciliberto, G, Cortese, R, Bazzo, R, Shiver, J.W, Pessi, A. | 登録日 | 2002-10-08 | 公開日 | 2003-09-02 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural analysis of the epitope of the anti-HIV antibody 2F5 sheds light into its mechanism of neutralization and HIV fusion. J.Mol.Biol., 330, 2003
|
|
1N1Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1n1y by Molmil](/molmil-images/mine/1n1y) | Trypanosoma rangeli sialidase in complex with sialic acid | 分子名称: | N-acetyl-alpha-neuraminic acid, Sialidase | 著者 | Amaya, M.F, Buschiazzo, A, Nguyen, T, Alzari, P.M. | 登録日 | 2002-10-21 | 公開日 | 2003-01-07 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The high resolution structures of free and inhibitor-bound
Trypanosoma rangeli sialidase and its comparison with T.
cruzi trans-sialidase J.Mol.Biol., 325, 2003
|
|
1N1T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1n1t by Molmil](/molmil-images/mine/1n1t) | Trypanosoma rangeli sialidase in complex with DANA at 1.6 A | 分子名称: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, SULFATE ION, Sialidase | 著者 | Amaya, M.F, Buschiazzo, A, Nguyen, T, Alzari, P.M. | 登録日 | 2002-10-20 | 公開日 | 2003-01-07 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The high resolution structures of free and
inhibitor-bound Trypanosoma rangeli
sialidase and its comparison with T. cruzi
trans-sialidase J.Mol.Biol., 325, 2003
|
|
8T0Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t0q by Molmil](/molmil-images/mine/8t0q) | Open state of lysine 5,6-aminomutase from Thermoanaerobacter tengcongensis | 分子名称: | 5'-DEOXYADENOSINE, COBALAMIN, D-lysine 5,6-aminomutase alpha subunit, ... | 著者 | Tian, S, Voss, P, Pham, K, Klose, T. | 登録日 | 2023-06-01 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Catalysis in Motion: Large-Scale Domain Shift Enables Co-C Bond Homolysis in Lysine 5,6-Aminomutase To Be Published
|
|
7YG8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yg8 by Molmil](/molmil-images/mine/7yg8) | Cryo-EM structure of Tetrahymena ribozyme conformation 5 undergoing the second-step self-splicing | 分子名称: | MAGNESIUM ION, RNA (387-MER), RNA (5'-R(*CP*CP*CP*UP*C)-3'), ... | 著者 | Li, S, Michael, Z.P, Zhang, X, Greg, P, Zhang, K. | 登録日 | 2022-07-11 | 公開日 | 2023-03-29 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Snapshots of the second-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM. Nat Commun, 14, 2023
|
|
7YGD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ygd by Molmil](/molmil-images/mine/7ygd) | Cryo-EM structure of Tetrahymena ribozyme conformation 6 undergoing the second-step self-splicing | 分子名称: | MAGNESIUM ION, RNA (384-MER), RNA (5'-R(*CP*C)-3'), ... | 著者 | Li, S, Michael, Z.P, Zhang, X, Greg, P, Zhang, K. | 登録日 | 2022-07-11 | 公開日 | 2023-03-29 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | Snapshots of the second-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM. Nat Commun, 14, 2023
|
|
2YIH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2yih by Molmil](/molmil-images/mine/2yih) | Structure of a Paenibacillus polymyxa Xyloglucanase from GH family 44 with Xyloglucan | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, CEL44C, ... | 著者 | Ariza, A, Eklof, J.M, Spadiut, O, Offen, W.A, Roberts, S.M, Besenmatter, W, Friis, E.P, Skjot, M, Wilson, K.S, Brumer, H, Davies, G. | 登録日 | 2011-05-13 | 公開日 | 2011-06-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure and Activity of Paenibacillus Polymyxa Xyloglucanase from Glycoside Hydrolase Family 44. J.Biol.Chem., 286, 2011
|
|