4FAJ

Structure and mode of peptide binding of pheromone receptor PrgZ

Summary for 4FAJ

Entry DOI	10.2210/pdb4faj/pdb
Descriptor	PrgZ, Sex pheromone cCF10, GLYCEROL, ... (5 entities in total)
Functional Keywords	substrate binding protein, peptide binding protein, pheromone, extracellular, membrane anchored
Biological source	Enterococcus faecalis More
Total number of polymer chains	2
Total formula weight	64563.60
Authors	Berntsson, R.P.-A.,Schuurman-Wolters, G.K.,Dunny, K.,Slotboom, D.J.,Poolman, B. (deposition date: 2012-05-22, release date: 2012-09-12, Last modification date: 2024-02-28)
Primary citation	Berntsson, R.P.,Schuurman-Wolters, G.K.,Dunny, G.,Slotboom, D.J.,Poolman, B. Structure and Mode of Peptide Binding of Pheromone Receptor PrgZ. J.Biol.Chem., 287:37165-37170, 2012 Cited by PubMed Abstract: We present the crystal structure of the pheromone receptor protein PrgZ from Enterococcus faecalis in complex with the heptapeptide cCF10 (LVTLVFV), which is used in signaling between conjugative recipient and donor cells. Comparison of PrgZ with homologous oligopeptide-binding proteins (AppA and OppA) explains the high specificity of PrgZ for hydrophobic heptapeptides versus the promiscuity of peptide binding in the homologous proteins. PubMed: 22948145 DOI: 10.1074/jbc.M112.386334 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation