6R6A
 
 | | Major aspartyl peptidase 1 from C. neoformans | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, Endopeptidase, ... | | 著者 | Krystufek, R, Sacha, P, Brynda, J, Konvalinka, J. | | 登録日 | 2019-03-26 | | 公開日 | 2021-04-07 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery.
J.Med.Chem., 64, 2021
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6I6K
 | | Papaver somniferum O-methyltransferase 1 | | 分子名称: | (13aS)-3,10-dimethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline-2,9-diol, O-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Cabry, M.P, Offen, W.A, Winzer, T, Li, Y, Graham, I.A, Davies, G.J, Saleh, P. | | 登録日 | 2018-11-15 | | 公開日 | 2019-03-27 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Structure of Papaver somniferum O-Methyltransferase 1 Reveals Initiation of Noscapine Biosynthesis with Implications for Plant Natural Product Methylation
Acs Catalysis, 2019
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5NFE
 | | Neutron structure of human transthyretin (TTR) T119M mutant at room temperature to 1.85A resolution | | 分子名称: | Transthyretin | | 著者 | Yee, A.W, Moulin, M, Blakeley, M.P, Ostermann, A, Cooper, J.B, Haertlein, M, Mitchell, E.P, Forsyth, V.T. | | 登録日 | 2017-03-14 | | 公開日 | 2019-01-02 | | 最終更新日 | 2024-05-01 | | 実験手法 | NEUTRON DIFFRACTION (1.853 Å), X-RAY DIFFRACTION | | 主引用文献 | A molecular mechanism for transthyretin amyloidogenesis.
Nat Commun, 10, 2019
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7UMK
 | | Structure of vesicular stomatitis virus (helical reconstruction, 4.1 A resolution) | | 分子名称: | Matrix protein, Nucleoprotein, RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') | | 著者 | Jenni, S, Horwitz, J.A, Bloyet, L.-M, Whelan, S.P.J, Harrison, S.C. | | 登録日 | 2022-04-07 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Visualizing molecular interactions that determine assembly of a bullet-shaped vesicular stomatitis virus particle.
Nat Commun, 13, 2022
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7UML
 | | Structure of vesicular stomatitis virus (local reconstruction, 3.5 A resolution) | | 分子名称: | Matrix protein, Nucleoprotein, RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') | | 著者 | Jenni, S, Horwitz, J.A, Bloyet, L.-M, Whelan, S.P.J, Harrison, S.C. | | 登録日 | 2022-04-07 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Visualizing molecular interactions that determine assembly of a bullet-shaped vesicular stomatitis virus particle.
Nat Commun, 13, 2022
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6I9C
 | | Structure of the OTU domain of OTULIN G281R mutant | | 分子名称: | CHLORIDE ION, GLYCEROL, Ubiquitin thioesterase otulin | | 著者 | Damgaard, R.B, Elliott, P.R, Swatek, K.N, Maher, E.R, Stepensky, P, Elpeleg, O, Komander, D, Berkun, Y. | | 登録日 | 2018-11-22 | | 公開日 | 2019-03-06 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | OTULIN deficiency in ORAS causes cell type-specific LUBAC degradation, dysregulated TNF signalling and cell death.
Embo Mol Med, 11, 2019
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6IBS
 | | Crystal structure of NDM-1 beta-lactamase in complex with boronic inhibitor cpd 6 | | 分子名称: | CALCIUM ION, Metallo-beta-lactamase type 2, ZINC ION, ... | | 著者 | Maso, L, Quotadamo, A, Bellio, P, Montanari, M, Venturelli, A, Celenza, G, Costi, M.P, Tondi, D, Cendron, L. | | 登録日 | 2018-11-30 | | 公開日 | 2019-04-24 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | | 主引用文献 | X-ray Crystallography Deciphers the Activity of Broad-Spectrum Boronic Acid beta-Lactamase Inhibitors.
Acs Med.Chem.Lett., 10, 2019
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6I5Q
 | | Papaver somniferum O-methyltransferase 1 | | 分子名称: | O-methyltransferase 1 | | 著者 | Cabry, M.P, Offen, W.A, Winzer, T, Li, Y, Graham, I.A, Davies, G.J, Saleh, P. | | 登録日 | 2018-11-14 | | 公開日 | 2019-03-27 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | Structure of Papaver somniferum O-Methyltransferase 1 Reveals Initiation of Noscapine Biosynthesis with Implications for Plant Natural Product Methylation
Acs Catalysis, 2019
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5I32
 | | Ammonia permeable aquaporin AtTIP2;1 | | 分子名称: | Aquaporin TIP2-1 | | 著者 | Kirscht, A, Nissen, P, Kjellbom, P, Gourdon, P, Johanson, U. | | 登録日 | 2016-02-09 | | 公開日 | 2016-04-06 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | | 主引用文献 | Crystal Structure of an Ammonia-Permeable Aquaporin.
Plos Biol., 14, 2016
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1K57
 | | OXA 10 class D beta-lactamase at pH 6.0 | | 分子名称: | BETA LACTAMASE OXA-10, SULFATE ION | | 著者 | Golemi, D, Maveyraud, L, Vakulenko, S, Samama, J.P, Mobashery, S. | | 登録日 | 2001-10-10 | | 公開日 | 2001-11-07 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Critical involvement of a carbamylated lysine in catalytic function of class D beta-lactamases.
Proc.Natl.Acad.Sci.USA, 98, 2001
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6I6L
 | | Papaver somniferum O-methyltransferase 1 | | 分子名称: | O-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, Tetrahydrocolumbamine | | 著者 | Cabry, M.P, Offen, W.A, Winzer, T, Li, Y, Graham, I.A, Davies, G.J, Saleh, P. | | 登録日 | 2018-11-15 | | 公開日 | 2019-03-27 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | | 主引用文献 | Structure of Papaver somniferum O-Methyltransferase 1 Reveals Initiation of Noscapine Biosynthesis with Implications for Plant Natural Product Methylation
Acs Catalysis, 2019
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5NJK
 | | PTB domain of human Numb isoform-1 | | 分子名称: | ALA-TYR-ILE-GLY-PRO-PTR-LEU, Protein numb homolog, SULFATE ION | | 著者 | Mapelli, M, Di Fiore, P.P. | | 登録日 | 2017-03-29 | | 公開日 | 2017-12-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.13 Å) | | 主引用文献 | A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer.
J. Cell Biol., 217, 2018
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8AFJ
 | | tRNA modifying enzyme MiaE soaked in Na-dithionite in a glovebox and flash-cooled using a miniature-airlock | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, CHLORIDE ION, ... | | 著者 | van der Linden, P, Engilberge, S, Atta, M, Carpentier, P. | | 登録日 | 2022-07-18 | | 公開日 | 2023-03-29 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | tRNA modifying enzyme MiaE soaked in Na-dithionite in a glovebox and flash-cooled using a miniature-airlock
To Be Published
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3E8C
 | | Crystal structures of the kinase domain of PKA in complex with ATP-competitive inhibitors | | 分子名称: | 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-6-{[(2R)-2-amino-3-phenylpropyl]oxy}-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor peptide | | 著者 | Concha, N.O, Elkins, P.A, Smallwood, A, Ward, P. | | 登録日 | 2008-08-19 | | 公開日 | 2008-11-18 | | 最終更新日 | 2017-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Aminofurazans as potent inhibitors of AKT kinase
Bioorg.Med.Chem.Lett., 19, 2009
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8I0Q
 | | Structure of beta-arrestin1 in complex with a phosphopeptide corresponding to the human C-X-C chemokine receptor type 4, CXCR4 (Local refine) | | 分子名称: | Beta-arrestin-1, C-X-C chemokine receptor type 4, Fab30 Heavy Chain, ... | | 著者 | Maharana, J, Sarma, P, Yadav, M.K, Banerjee, R, Shukla, A.K. | | 登録日 | 2023-01-11 | | 公開日 | 2023-05-17 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (4.45 Å) | | 主引用文献 | Structural snapshots uncover a key phosphorylation motif in GPCRs driving beta-arrestin activation.
Mol.Cell, 83, 2023
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8I10
 | | Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human Vasopressin V2 receptor, V2R (Local refine) | | 分子名称: | Beta-arrestin-2, Fab30 Heavy Chain, Fab30 Light Chain, ... | | 著者 | Maharana, J, Sarma, P, Yadav, M.K, Banerjee, R, Shukla, A.K. | | 登録日 | 2023-01-12 | | 公開日 | 2023-05-17 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.96 Å) | | 主引用文献 | Structural snapshots uncover a key phosphorylation motif in GPCRs driving beta-arrestin activation.
Mol.Cell, 83, 2023
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6I20
 | | Flavin Analogue Sheds Light on Light-Oxygen-Voltage Domain Mechanism | | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETATE ION, ... | | 著者 | Rizkallah, P.J, Kalvaitis, M.E, Allemann, R.K, Mart, R.J, Johnson, L.A. | | 登録日 | 2018-10-31 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | | 主引用文献 | A Noncanonical Chromophore Reveals Structural Rearrangements of the Light-Oxygen-Voltage Domain upon Photoactivation.
Biochemistry, 58, 2019
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1BZG
 | | THE SOLUTION STRUCTURE OF HUMAN PARATHYROID HORMONE-RELATED PROTEIN (1-34) IN NEAR-PHYSIOLOGICAL SOLUTION, NMR, 30 STRUCTURES | | 分子名称: | PARATHYROID HORMONE-RELATED PROTEIN | | 著者 | Weidler, M, Marx, U.C, Seidel, G, Roesch, P. | | 登録日 | 1998-10-28 | | 公開日 | 1999-05-18 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The structure of human parathyroid hormone-related protein(1-34) in near-physiological solution.
FEBS Lett., 444, 1999
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5MLB
 | | Crystal structure of human RAS in complex with darpin K27 | | 分子名称: | DARPin K27, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Debreczeni, J.E, Guillard, S, Kolasinska-Zwierz, P, Breed, J, Zhang, J, Bery, N, Marwood, R, Tart, J, Overman, R, Stocki, P, Mistry, B, Phillips, C, Rabbitts, T, Jackson, R, Minter, R. | | 登録日 | 2016-12-06 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | | 主引用文献 | INhibition of RAS nucleotide exchange by a DARPin: structural characterisation and effects on downstream signalling by active RAS
To Be Published
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5MMM
 | | Structure of the 70S chloroplast ribosome | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein 2, ... | | 著者 | Bieri, P, Leibundgut, M, Saurer, M, Boehringer, D, Ban, N. | | 登録日 | 2016-12-11 | | 公開日 | 2017-01-11 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | The complete structure of the chloroplast 70S ribosome in complex with translation factor pY.
EMBO J., 36, 2017
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6Y3O
 | | 14-3-3 Sigma in complex with phosphorylated CAMKK2 peptide | | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, CAMKK2, ... | | 著者 | Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. | | 登録日 | 2020-02-18 | | 公開日 | 2020-10-14 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | A new soaking procedure for X-ray crystallographic structural determination of protein-peptide complexes.
Acta Crystallogr.,Sect.F, 76, 2020
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8T6E
 | | Crystal structure of T33-28.3: Deep-learning sequence design of co-assembling tetrahedron protein nanoparticles | | 分子名称: | T33-28.3: A, T33-28.3: B | | 著者 | Bera, A.K, de Haas, R.J, Kang, A, Sankaran, B, King, N.P. | | 登録日 | 2023-06-15 | | 公開日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Rapid and automated design of two-component protein nanomaterials using ProteinMPNN.
Proc.Natl.Acad.Sci.USA, 121, 2024
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6HAU
 | | KSHV PAN RNA Mta-response element fragment complexed with the globular domain of herpesvirus saimiri ORF57 | | 分子名称: | ACETATE ION, MRE fragment of PAN RNA, ZINC ION, ... | | 著者 | Tunnicliffe, R.B, Levy, C, Ruiz Nivia, H.D, Sandri-Goldin, R.M, Golovanov, A.P. | | 登録日 | 2018-08-08 | | 公開日 | 2018-11-21 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Structural identification of conserved RNA binding sites in herpesvirus ORF57 homologs: implications for PAN RNA recognition.
Nucleic Acids Res., 47, 2019
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8G4Y
 | | Structure of ZNRF3 ECD bound to peptide MK1-3.6.10 | | 分子名称: | E3 ubiquitin-protein ligase ZNRF3, MK1-3.6.10 | | 著者 | Harris, S.F, Wu, P. | | 登録日 | 2023-02-10 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-07-03 | | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | | 主引用文献 | Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth.
Cell Chem Biol, 31, 2024
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8GO9
 | | Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human Atypical chemokine receptor 2, ACKR2 (D6R) | | 分子名称: | Atypical chemokine receptor 2, Beta-arrestin-2, Fab30 Heavy Chain, ... | | 著者 | Maharana, J, Sarma, P, Yadav, M.K, Banerjee, R, Shukla, A.K. | | 登録日 | 2022-08-24 | | 公開日 | 2023-12-27 | | 最終更新日 | 2024-01-17 | | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | | 主引用文献 | Molecular insights into atypical modes of beta-arrestin interaction with seven transmembrane receptors.
Science, 383, 2024
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