8G4Y
Structure of ZNRF3 ECD bound to peptide MK1-3.6.10
Summary for 8G4Y
Entry DOI | 10.2210/pdb8g4y/pdb |
Descriptor | E3 ubiquitin-protein ligase ZNRF3, MK1-3.6.10 (3 entities in total) |
Functional Keywords | ubiquitin ligase, wnt signal, cell surface, ckp, ligase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 24162.19 |
Authors | Harris, S.F.,Wu, P. (deposition date: 2023-02-10, release date: 2023-12-20, Last modification date: 2024-07-03) |
Primary citation | Kschonsak, Y.T.,Gao, X.,Miller, S.E.,Hwang, S.,Marei, H.,Wu, P.,Li, Y.,Ruiz, K.,Dorighi, K.,Holokai, L.,Perampalam, P.,Tsai, W.K.,Kee, Y.S.,Agard, N.J.,Harris, S.F.,Hannoush, R.N.,de Sousa E Melo, F. Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth. Cell Chem Biol, 31:1176-, 2024 Cited by PubMed: 38056465DOI: 10.1016/j.chembiol.2023.11.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.41 Å) |
Structure validation
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