8G4Y

Structure of ZNRF3 ECD bound to peptide MK1-3.6.10

Summary for 8G4Y

• Entry DOI: 10.2210/pdb8g4y/pdb
• Descriptor: E3 ubiquitin-protein ligase ZNRF3, MK1-3.6.10 (3 entities in total)
• Functional Keywords: ubiquitin ligase, wnt signal, cell surface, ckp, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 24162.19

Authors

Harris, S.F.,Wu, P. (deposition date: 2023-02-10, release date: 2023-12-20)

• Primary citation: Kschonsak, Y.T.,Gao, X.,Miller, S.E.,Hwang, S.,Marei, H.,Wu, P.,Li, Y.,Ruiz, K.,Dorighi, K.,Holokai, L.,Perampalam, P.,Tsai, W.K.,Kee, Y.S.,Agard, N.J.,Harris, S.F.,Hannoush, R.N.,de Sousa E Melo, F.; Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth.; Cell Chem Biol, 2023; PubMed: 38056465; DOI: 10.1016/j.chembiol.2023.11.006

Experimental method

X-RAY DIFFRACTION (1.41 Å)