6I9C
Structure of the OTU domain of OTULIN G281R mutant
Summary for 6I9C
Entry DOI | 10.2210/pdb6i9c/pdb |
Descriptor | Ubiquitin thioesterase otulin, GLYCEROL, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | met1-specific deubiquitinase, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 31668.79 |
Authors | Damgaard, R.B.,Elliott, P.R.,Swatek, K.N.,Maher, E.R.,Stepensky, P.,Elpeleg, O.,Komander, D.,Berkun, Y. (deposition date: 2018-11-22, release date: 2019-03-06, Last modification date: 2024-05-15) |
Primary citation | Damgaard, R.B.,Elliott, P.R.,Swatek, K.N.,Maher, E.R.,Stepensky, P.,Elpeleg, O.,Komander, D.,Berkun, Y. OTULIN deficiency in ORAS causes cell type-specific LUBAC degradation, dysregulated TNF signalling and cell death. Embo Mol Med, 11:-, 2019 Cited by PubMed: 30804083DOI: 10.15252/emmm.201809324 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.77 Å) |
Structure validation
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