6I9C

Structure of the OTU domain of OTULIN G281R mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	1990108	biological_process	protein linear deubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue GOL A 401

Chain	Residue
A	ASP268
A	GLY270
A	ARG274
A	GOL402
A	HOH533

---

site_id	AC2
Number of Residues	5
Details	binding site for residue GOL A 402

Chain	Residue
A	HOH606
A	TYR165
A	TRP167
A	ASN245
A	GOL401

---

site_id	AC3
Number of Residues	6
Details	binding site for residue GOL A 403

Chain	Residue
A	GLU95
A	TRP96
A	ARG97
A	LYS116
A	GLN303
A	THR331

---

site_id	AC4
Number of Residues	6
Details	binding site for residue GOL A 404

Chain	Residue
A	ASN127
A	LYS233
A	HIS276
A	LEU277
A	GLN279
A	HOH605

---

site_id	AC5
Number of Residues	3
Details	binding site for residue CL A 405

Chain	Residue
A	LYS94
A	VAL318
A	HOH565

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Region: {"description":"Linear diubiquitin binding","evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Region: {"description":"Linear diubiquitin binding","evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24726327","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Site: {"description":"Linear diubiquitin binding","evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---