6R6A

Major aspartyl peptidase 1 from C. neoformans

Summary for 6R6A

Entry DOI	10.2210/pdb6r6a/pdb
Related	6R5H 6R61
Descriptor	Endopeptidase, Pepstatin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywords	aspartyl protease, secreted, cryptococcus neoformans, hydrolase
Biological source	Cryptococcus neoformans var. grubii More
Total number of polymer chains	2
Total formula weight	39448.03
Authors	Krystufek, R.,Sacha, P.,Brynda, J.,Konvalinka, J. (deposition date: 2019-03-26, release date: 2021-04-07, Last modification date: 2024-01-24)
Primary citation	Krystufek, R.,Sacha, P.,Starkova, J.,Brynda, J.,Hradilek, M.,Tloust'ova, E.,Grzymska, J.,Rut, W.,Boucher, M.J.,Drag, M.,Majer, P.,Hajek, M.,Rezacova, P.,Madhani, H.D.,Craik, C.S.,Konvalinka, J. Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery. J.Med.Chem., 64:6706-6719, 2021 Cited by PubMed: 34006103 DOI: 10.1021/acs.jmedchem.0c02177 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation