4RP0
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8FK9
| Crystal Structure of the Tick Evasin EVA-ACA1001 Complexed to Human Chemokine CCL16 | 分子名称: | C-C motif chemokine 16, Evasin P991 | 著者 | Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J. | 登録日 | 2022-12-21 | 公開日 | 2024-01-17 | 最終更新日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis of chemokine recognition by the class A3 tick evasin EVA-ACA1001. Protein Sci., 33, 2024
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6NNZ
| Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 4 | 分子名称: | ATP-dependent dethiobiotin synthetase BioD, SULFATE ION, [(1R,2S)-2-(benzenecarbonyl)cyclopentyl]acetic acid, ... | 著者 | Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B. | 登録日 | 2019-01-15 | 公開日 | 2020-01-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 4 To Be Published
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8WUL
| Crystal structure of affinity enhanced TCR in complex with HLA-A*11:01 bound to KRAS-G12V peptide (VVGAVGVGK) | 分子名称: | Beta-2-microglobulin, KRAS-G12V nonamer peptide, MHC class I antigen, ... | 著者 | Zhang, M.Y, Luo, L.J, Xu, W, Guan, F.H, Wang, X.Y, Zhu, P, Zhang, J.H, Zhou, X.Y, Wang, F, Ye, S. | 登録日 | 2023-10-20 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | 主引用文献 | Identification and affinity enhancement of T-cell receptor targeting a KRAS G12V cancer neoantigen. Commun Biol, 7, 2024
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6NTJ
| Neutron/X-ray crystal structure of AAC-VIa bound to gentamicin C1A | 分子名称: | (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, Aminoglycoside N(3)-acetyltransferase, MAGNESIUM ION | 著者 | Cuneo, M.J, Kumar, P. | 登録日 | 2019-01-29 | 公開日 | 2019-09-25 | 最終更新日 | 2024-04-03 | 実験手法 | NEUTRON DIFFRACTION (1.9 Å), X-RAY DIFFRACTION | 主引用文献 | Low-Barrier and Canonical Hydrogen Bonds Modulate Activity and Specificity of a Catalytic Triad. Angew.Chem.Int.Ed.Engl., 58, 2019
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6YV5
| Crystal Structure of Serine protease SplB N3Q/S154R from Staphylococcus aureus | 分子名称: | SODIUM ION, Serine protease | 著者 | Rangel Pereira, M.R, Brear, P, Knyphausen, P, Jermutus, L, Hollfelder, F. | 登録日 | 2020-04-27 | 公開日 | 2021-05-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Crystal Structure of Serine protease SplB N3Q/S154R from Staphylococcus aureus To Be Published
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8JFV
| Crystal structure of Catabolite repressor acivator from E. coli in complex with sulisobenzone | 分子名称: | 1,2-ETHANEDIOL, 2-methoxy-4-oxidanyl-5-(phenylcarbonyl)benzenesulfonic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Neetu, N, Sharma, M, Mahto, J.K, Kumar, P. | 登録日 | 2023-05-19 | 公開日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Sulisobenzone is a potent inhibitor of the global transcription factor Cra. J.Struct.Biol., 215, 2023
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8AS2
| Structure of arrestin2 in complex with 4P CCR5 phosphopeptide and Fab30 | 分子名称: | Beta-arrestin-1, C-C chemokine receptor type 5, Fab30 heavy chain, ... | 著者 | Isaikina, P, Jakob, R.P, Maier, T, Grzesiek, S. | 登録日 | 2022-08-18 | 公開日 | 2023-06-07 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | A key GPCR phosphorylation motif discovered in arrestin2⋅CCR5 phosphopeptide complexes. Mol.Cell, 83, 2023
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3D5H
| Crystal structure of haementhin from Haemanthus multiflorus at 2.0A resolution: Formation of a novel loop on a TIM barrel fold and its functional significance | 分子名称: | ACETATE ION, Haementhin, PHOSPHATE ION | 著者 | Kumar, S, Singh, N, Sinha, M, Singh, S.B, Bhushan, A, Kaur, P, Srinivasan, A, Sharma, S, Singh, T.P. | 登録日 | 2008-05-16 | 公開日 | 2009-03-31 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of haementhin from Haemanthus multiflorus at 2.0A resolution: Formation of a novel loop on a TIM barrel fold and its functional significance To be Published
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8FOP
| Structure of Agrobacterium tumefaciens bacteriophage Milano curved tail | 分子名称: | Tail sheath protein, Virion-associated protein | 著者 | Sonani, R.R, Leiman, P.G, Wang, F, Kreutzberger, M.A.B, Sebastian, A, Esteves, N.C, Kelly, R.J, Scharf, B, Egelman, E.H. | 登録日 | 2023-01-03 | 公開日 | 2024-01-17 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | An extensive disulfide bond network prevents tail contraction in Agrobacterium tumefaciens phage Milano. Nat Commun, 15, 2024
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6HLO
| Crystal structure of the Neurokinin 1 receptor in complex with the small molecule antagonist Aprepitant | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one, CITRIC ACID, ... | 著者 | Schoppe, J, Ehrenmann, J, Klenk, C, Rucktooa, P, Schutz, M, Dore, A.S, Pluckthun, A. | 登録日 | 2018-09-11 | 公開日 | 2019-01-16 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists. Nat Commun, 10, 2019
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6NP2
| AAC-VIa bound to Sisomicin | 分子名称: | (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, Aminoglycoside N(3)-acetyltransferase, MAGNESIUM ION | 著者 | Kumar, P, Cuneo, M.J. | 登録日 | 2019-01-17 | 公開日 | 2019-09-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Low-Barrier and Canonical Hydrogen Bonds Modulate Activity and Specificity of a Catalytic Triad. Angew.Chem.Int.Ed.Engl., 58, 2019
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6NU6
| Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 5 | 分子名称: | 4-[(1R,2S)-2-(carboxymethyl)cyclopentane-1-carbonyl]benzoic acid, 4-[(1S,2R)-2-(carboxymethyl)cyclopentane-1-carbonyl]benzoic acid, ATP-dependent dethiobiotin synthetase BioD, ... | 著者 | Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B. | 登録日 | 2019-01-31 | 公開日 | 2020-02-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.437 Å) | 主引用文献 | Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 5 To Be Published
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6NVE
| Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 7 | 分子名称: | 4-{[(1S,2S)-2-(carboxymethyl)cyclopentyl]methyl}benzoic acid, ATP-dependent dethiobiotin synthetase BioD, SULFATE ION | 著者 | Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B. | 登録日 | 2019-02-05 | 公開日 | 2020-02-12 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 7 To Be Published
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6ZHF
| Calcium ATPase-1 from Listeria monocytogenes in complex with BeF | 分子名称: | BERYLLIUM TRIFLUORIDE ION, Calcium-transporting ATPase, MAGNESIUM ION | 著者 | Basse Hansen, S, Dyla, M, Neumann, C, Quistgaard, E.M.H, Lauwring Andersen, J, Kjaergaard, M, Nissen, P. | 登録日 | 2020-06-23 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | The Crystal Structure of the Ca 2+ -ATPase 1 from Listeria monocytogenes reveals a Pump Primed for Dephosphorylation. J.Mol.Biol., 433, 2021
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6U6C
| Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK2-bound form | 分子名称: | 1,2-ETHANEDIOL, 1-(2-fluorobenzene-1-carbonyl)-N-methyl-2,3-dihydro-1H-indole-5-sulfonamide, 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, ... | 著者 | Chang, C, Michalska, K, Maltseva, N.I, Jedrzejczak, R, McCarren, P, Nag, P.P, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2019-08-29 | 公開日 | 2020-09-02 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.402 Å) | 主引用文献 | Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase. Protein Sci., 29, 2020
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5KMI
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6NVC
| Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 6 | 分子名称: | ATP-dependent dethiobiotin synthetase BioD, SULFATE ION, {(1S,2R)-2-[4-(carboxymethyl)benzene-1-carbonyl]cyclopentyl}acetic acid | 著者 | Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B. | 登録日 | 2019-02-04 | 公開日 | 2020-02-12 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 6 To Be Published
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7UPG
| Tau Paired Helical Filament from Alzheimer's Disease incubated with EGCG for 3 hours | 分子名称: | (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, Isoform Tau-F of Microtubule-associated protein tau | 著者 | Seidler, P.M, Murray, K.A, Boyer, D.R, Ge, P, Sawaya, M.R, Eisenberg, D.S. | 登録日 | 2022-04-15 | 公開日 | 2022-09-28 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro. Nat Commun, 13, 2022
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6O28
| Crystal structure of 4493 Fab in complex with circumsporozoite protein KQPA and anti-kappa VHH domain | 分子名称: | 1,2-ETHANEDIOL, 4493 Fab heavy chain, 4493 Kappa light chain, ... | 著者 | Scally, S.W, Bosch, A, Prieto, K, Murugan, R, Wardemann, H, Julien, J.P. | 登録日 | 2019-02-22 | 公開日 | 2020-07-01 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs. Nat. Med., 26, 2020
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8AVT
| Racemic protein crystal structure of aureocin A53 from Staphylococcus aureus in the presence of glycerol 3-phosphate | 分子名称: | 1,2-ETHANEDIOL, Bacteriocin aureocin A53, D-Aureocin A53, ... | 著者 | Lander, A.J, Baumann, P, Rizkallah, P, Jin, Y, Luk, L.Y.P. | 登録日 | 2022-08-26 | 公開日 | 2023-07-26 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Roles of inter- and intramolecular tryptophan interactions in membrane-active proteins revealed by racemic protein crystallography. Commun Chem, 6, 2023
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5HPW
| Mode of binding of antithyroid drug, propylthiouracil to lactoperoxidase: Binding studies and structure determination | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Singh, R.P, Singh, A, Sharma, P, Kaur, P, Sharma, S, Singh, T.P. | 登録日 | 2016-01-21 | 公開日 | 2016-04-20 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Mode of binding of antithyroid drug, propylthiouracil to lactoperoxidase: Binding studies and structure determination To Be Published
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6H03
| OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5,Complement C5, ... | 著者 | Menny, A, Serna, M, Boyd, C.M, Gardner, S, Joseph, A.P, Topf, M, Bubeck, D. | 登録日 | 2018-07-06 | 公開日 | 2018-12-19 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (5.6 Å) | 主引用文献 | CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers. Nat Commun, 9, 2018
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6O29
| Crystal structure of 4493 Fab in complex with circumsporozoite protein NPDP and anti-kappa VHH domain | 分子名称: | 1,2-ETHANEDIOL, 4493 Fab heavy chain, 4493 Kappa light chain, ... | 著者 | Scally, S.W, Bosch, A, Prieto, K, Murugan, R, Wardemann, H, Julien, J.P. | 登録日 | 2019-02-22 | 公開日 | 2020-07-01 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs. Nat. Med., 26, 2020
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7UJL
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