6HLO
Crystal structure of the Neurokinin 1 receptor in complex with the small molecule antagonist Aprepitant
Summary for 6HLO
Entry DOI | 10.2210/pdb6hlo/pdb |
Descriptor | Substance-P receptor,GlgA glycogen synthase,Substance-P receptor, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one, CITRIC ACID, ... (6 entities in total) |
Functional Keywords | 7-tm; gpcr; signalling protein, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 65746.17 |
Authors | Schoppe, J.,Ehrenmann, J.,Klenk, C.,Rucktooa, P.,Schutz, M.,Dore, A.S.,Pluckthun, A. (deposition date: 2018-09-11, release date: 2019-01-16, Last modification date: 2024-01-24) |
Primary citation | Schoppe, J.,Ehrenmann, J.,Klenk, C.,Rucktooa, P.,Schutz, M.,Dore, A.S.,Pluckthun, A. Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists. Nat Commun, 10:17-17, 2019 Cited by PubMed: 30604743DOI: 10.1038/s41467-018-07939-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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