8DE8
 
 | | Cryo-EM structure of the zebrafish two pore domain K+ channel TREK1 (K2P2.1) in DDM/POPA mixed micelles | | 分子名称: | (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, POTASSIUM ION, Potassium channel, ... | | 著者 | Schmidpeter, P.A.M, Nimigean, C.M, Riegelhaupt, P.M. | | 登録日 | 2022-06-20 | | 公開日 | 2023-03-08 | | 実験手法 | ELECTRON MICROSCOPY (2.82 Å) | | 主引用文献 | Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1.
Nat Commun, 14, 2023
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8DE9
 | | Cryo-EM structure of the zebrafish two pore domain K+ channel TREK1 (K2P2.1) in DDM/POPE mixed micelles | | 分子名称: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, POTASSIUM ION, Potassium channel, ... | | 著者 | Schmidpeter, P.A.M, Nimigean, C.M, Riegelhaupt, P.M. | | 登録日 | 2022-06-20 | | 公開日 | 2023-03-08 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1.
Nat Commun, 14, 2023
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8FEC
 | | Structure of J-PKAc chimera complexed with Aplithianine derivative | | 分子名称: | 6-[(6P)-6-(4-bromo-1-methyl-1H-imidazol-5-yl)-2,3-dihydro-4H-1,4-thiazin-4-yl]-7H-purine, DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha | | 著者 | Du, L, Wilson, B.A.P, Li, N, Martinez Fiesco, J.A, Dalilian, M, Wang, D, Smith, E.A, Wamiru, A, Goncharova, E.I, Zhang, P, O'Keefe, B.R. | | 登録日 | 2022-12-06 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases.
J.Nat.Prod., 86, 2023
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7PBZ
 | | a1b3 GABA-A receptor + GABA + Zn2+ | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DECANE, ... | | 著者 | Miller, P.S, Kasaragod, V.B. | | 登録日 | 2021-08-03 | | 公開日 | 2022-02-09 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | | 主引用文献 | Mechanisms of inhibition and activation of extrasynaptic alpha beta GABA A receptors.
Nature, 602, 2022
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7PC0
 | | GABA-A receptor bound by a-Cobratoxin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-cobratoxin, ... | | 著者 | Kasaragod, V.B, Miller, P.S. | | 登録日 | 2021-08-03 | | 公開日 | 2022-02-09 | | 最終更新日 | 2022-03-02 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Mechanisms of inhibition and activation of extrasynaptic alpha beta GABA A receptors.
Nature, 602, 2022
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1AZQ
 | | HYPERTHERMOPHILE CHROMOSOMAL PROTEIN SAC7D BOUND WITH KINKED DNA DUPLEX | | 分子名称: | DNA (5'-D(*GP*TP*AP*AP*TP*TP*AP*C)-3'), PROTEIN (HYPERTHERMOPHILE CHROMOSOMAL PROTEIN SAC7D) | | 著者 | Robinson, H, Gao, Y.-G, Mccrary, B.S, Edmondson, S.P, Shriver, J.W, Wang, A.H.-J. | | 登録日 | 1997-11-20 | | 公開日 | 1999-01-13 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | The hyperthermophile chromosomal protein Sac7d sharply kinks DNA.
Nature, 392, 1998
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8FAT
 | | Crystal structure of Ky224 Fab in complex with circumsporozoite protein NPDP peptide | | 分子名称: | Circumsporozoite protein NPDP peptide, Ky224 Antibody, heavy chain, ... | | 著者 | Kassardjian, A, Thai, E, Julien, J.P. | | 登録日 | 2022-11-28 | | 公開日 | 2023-11-01 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein.
Cell Rep, 42, 2023
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7PBD
 | | a1b3 GABA-A receptor + GABA | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | | 著者 | Miller, P.S, Kasaragod, V.B. | | 登録日 | 2021-08-02 | | 公開日 | 2022-02-09 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Mechanisms of inhibition and activation of extrasynaptic alpha beta GABA A receptors.
Nature, 602, 2022
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8RKU
 | | Conformational Landscape of the Type V-K CRISPR-associated TransposonIntegration Assembly CAST V-K TnsC domain local-refinement map | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Non-target strand - LE, ... | | 著者 | Tenjo-Castano, F, Mesa, P, Montoya, G. | | 登録日 | 2023-12-30 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | Conformational landscape of the type V-K CRISPR-associated transposon integration assembly.
Mol.Cell, 84, 2024
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6ZBV
 | | Inward-open structure of human glycine transporter 1 in complex with a benzoylisoindoline inhibitor and sybody Sb_GlyT1#7 | | 分子名称: | Sodium- and chloride-dependent glycine transporter 1,Sodium- and chloride-dependent glycine transporter 1, Sybody Sb_GlyT1#7, [5-fluoranyl-6-(oxan-4-yloxy)-1,3-dihydroisoindol-2-yl]-[5-methylsulfonyl-2-[2,2,3,3,3-pentakis(fluoranyl)propoxy]phenyl]methanone | | 著者 | Shahsavar, A, Stohler, P, Bourenkov, G, Zimmermann, I, Siegrist, M, Guba, W, Pinard, E, Sinning, S, Seeger, M.A, Schneider, T.R, Dawson, R.J.P, Nissen, P. | | 登録日 | 2020-06-09 | | 公開日 | 2021-03-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structural insights into the inhibition of glycine reuptake.
Nature, 591, 2021
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8FB5
 | | Crystal structure of Ky15.11-S100IK Fab in complex with circumsporozoite protein KQPA peptide | | 分子名称: | Circumsporozoite protein KQPA peptide, Ky15.11-SK Antibody, heavy chain, ... | | 著者 | Kang, R.W, Thai, E, Julien, J.P. | | 登録日 | 2022-11-29 | | 公開日 | 2023-11-01 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein.
Cell Rep, 42, 2023
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7OQH
 | | CryoEM structure of the transcription termination factor Rho from Mycobacterium tuberculosis | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Transcription termination factor Rho | | 著者 | Saridakis, E, Vishwakarma, R, Lai Kee Him, J, Martin, K, Simon, I, Cohen-Gonsaud, M, Coste, F, Bron, P, Margeat, E, Boudvillain, M. | | 登録日 | 2021-06-03 | | 公開日 | 2022-02-09 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | | 主引用文献 | Cryo-EM structure of transcription termination factor Rho from Mycobacterium tuberculosis reveals bicyclomycin resistance mechanism.
Commun Biol, 5, 2022
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7OON
 | | The X-ray structure of heme-bound murine HEBP1 | | 分子名称: | Heme-binding protein 1, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | | 著者 | McEwen, A.G, Poussin-Courmontagne, P, Birck, C, Goodfellow, B.J. | | 登録日 | 2021-05-28 | | 公開日 | 2022-01-26 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The SOUL family of heme-binding proteins: Structure and function 15 years later
Coord. Chem. Rev, 448, 2021
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8RKT
 | | Conformational Landscape of the Type V-K CRISPR-associated TransposonIntegration Assembly CAST V-K Cas12k domain local-refinement map | | 分子名称: | MAGNESIUM ION, Non-target strand - LE, ShCas12k, ... | | 著者 | Tenjo-Castano, F, Mesa, P, Montoya, G. | | 登録日 | 2023-12-30 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.35 Å) | | 主引用文献 | Conformational landscape of the type V-K CRISPR-associated transposon integration assembly.
Mol.Cell, 84, 2024
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8FA9
 | | Crystal structure of Ky15.5 Fab in complex with circumsporozoite protein NPDP peptide | | 分子名称: | Circumsporozoite protein NPDP peptide, Ky15.5 Antibody, heavy chain, ... | | 著者 | Thai, E, Prieto, K, Julien, J.P. | | 登録日 | 2022-11-25 | | 公開日 | 2023-11-01 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein.
Cell Rep, 42, 2023
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7OPO
 | | RSK2 N-terminal kinase domain in complex with ORF45 | | 分子名称: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Protein ORF45, Ribosomal protein S6 kinase alpha-3 | | 著者 | Sok, P, Remenyi, A, Alexa, A, Poti, A. | | 登録日 | 2021-06-01 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host.
Nat Commun, 13, 2022
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8FAS
 | | Crystal structure of Ky230 Fab in complex with circumsporozoite protein NANP5 peptide | | 分子名称: | 1,2-ETHANEDIOL, Circumsporozoite protein NANP5 peptide, Ky230 Antibody, ... | | 著者 | Kassardjian, A, Thai, E, Julien, J.P. | | 登録日 | 2022-11-28 | | 公開日 | 2023-11-01 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein.
Cell Rep, 42, 2023
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8FDC
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8J9G
 | | CrtSPARTA hetero-dimer bound with guide-target, state 1 | | 分子名称: | DNA (25-MER), MAGNESIUM ION, Piwi domain-containing protein, ... | | 著者 | Li, Z.X, Guo, L.J, Huang, P.P, Xiao, Y.B, Chen, M.R. | | 登録日 | 2023-05-03 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system.
Nat.Chem.Biol., 20, 2024
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7QTV
 | | Beryllium fluoride form of the Na+,K+-ATPase (E2-BeFx) | | 分子名称: | 1-O-decanoyl-beta-D-tagatofuranosyl beta-D-allopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Fruergaard, M.U, Dach, I, Andersen, J.L, Ozol, M, Shahsavar, A, Quistgaard, E.M, Poulsen, H, Fedosova, N.U, Nissen, P. | | 登録日 | 2022-01-16 | | 公開日 | 2022-11-23 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (4.05 Å) | | 主引用文献 | The Na + ,K + -ATPase in complex with beryllium fluoride mimics an ATPase phosphorylated state.
J.Biol.Chem., 298, 2022
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8J8H
 | | SPARTA monomer bound with guide-target, state 2 | | 分子名称: | DNA (25-MER), MAGNESIUM ION, Piwi domain-containing protein, ... | | 著者 | Li, Z.X, Guo, L.J, Huang, P.P, Xiao, Y.B, Chen, M.R. | | 登録日 | 2023-05-01 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system.
Nat.Chem.Biol., 20, 2024
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4TU6
 | | Crystal structure of apo ATAD2A bromodomain with N1064 alternate conformation | | 分子名称: | ATPase family AAA domain-containing protein 2, SULFATE ION | | 著者 | Poncet-Montange, G, Zhan, Y, Bardenhagen, J, Petrocchi, A, Leo, E, Shi, X, Lee, G, Leonard, P, Geck Do, M, Cardozo, M, Palmer, W, Andersen, J, Jones, P, Ladbury, J. | | 登録日 | 2014-06-23 | | 公開日 | 2014-12-24 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
Biochem.J., 466, 2015
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5KT4
 | | Teranry complex of human DNA polymerase iota R96G inserting dCMPNPP opposite template G in the presence of Mg2+ | | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*CP*TP*GP*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), ... | | 著者 | Choi, J.Y, Patra, A, Yeom, M, Lee, Y.S, Zhang, Q, Egli, M, Guengerich, F.P. | | 登録日 | 2016-07-11 | | 公開日 | 2016-08-31 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | | 主引用文献 | Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota.
J.Biol.Chem., 291, 2016
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7QCA
 | | Spraguea lophii ribosome | | 分子名称: | 40S Ribosomal protein S19, 40S ribosomal protein S0, 40S ribosomal protein S10, ... | | 著者 | Gil Diez, P, McLaren, M, Isupov, M.N, Daum, B, Conners, R, Williams, B. | | 登録日 | 2021-11-22 | | 公開日 | 2022-11-30 | | 最終更新日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | | 主引用文献 | CryoEM reveals that ribosomes in microsporidian spores are locked in a dimeric hibernating state
Nat Microbiol, 2023
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1AE5
 | | HUMAN HEPARIN BINDING PROTEIN | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HEPARIN BINDING PROTEIN | | 著者 | Iversen, L.F, Kastrup, J.S, Bjorn, S.E, Rasmussen, P.B, Wiberg, F.C, Flodgaard, H.J, Larsen, I.K. | | 登録日 | 1997-03-05 | | 公開日 | 1998-03-11 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure of HBP, a multifunctional protein with a serine proteinase fold.
Nat.Struct.Biol., 4, 1997
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