8BPE
 
 | | 8:1 binding of FcMR on IgM pentameric core | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, ... | | 著者 | Chen, Q, Rosenthal, P, Tolar, P. | | 登録日 | 2022-11-16 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | | 主引用文献 | Structural basis for Fc receptor recognition of immunoglobulin M.
Nat.Struct.Mol.Biol., 30, 2023
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5MMA
 | | Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ379 (compound 5'g) | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... | | 著者 | Maskell, D.P, Pye, V.E, Cherepanov, P. | | 登録日 | 2016-12-09 | | 公開日 | 2017-08-02 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors.
J. Med. Chem., 60, 2017
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7PWY
 | | Structure of human dimeric ACMSD in complex with the inhibitor TES-1025 | | 分子名称: | 2-[3-[(5-cyano-6-oxidanylidene-4-thiophen-2-yl-1H-pyrimidin-2-yl)sulfanylmethyl]phenyl]ethanoic acid, 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase, POTASSIUM ION, ... | | 著者 | Cianci, M, Giacche, N, Carotti, A, Liscio, P, Amici, A, Cialabrini, L, De Franco, F, Pellicciari, R, Raffaelli, N. | | 登録日 | 2021-10-07 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural Basis of Human Dimeric alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase Inhibition With TES-1025.
Front Mol Biosci, 9, 2022
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6W6L
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6VOM
 | | Chloroplast ATP synthase (R2, CF1) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase delta chain, ... | | 著者 | Yang, J.-H, Williams, D, Kandiah, E, Fromme, P, Chiu, P.-L. | | 登録日 | 2020-01-30 | | 公開日 | 2020-09-09 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural basis of redox modulation on chloroplast ATP synthase.
Commun Biol, 3, 2020
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6YI7
 | | Structure of cathepsin B1 from Schistosoma mansoni (SmCB1) in complex with an azanitrile inhibitor | | 分子名称: | 1-[(2~{S})-1-[[iminomethyl(methyl)amino]-methyl-amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-3-(phenylmethyl)urea, ACETATE ION, Cathepsin B-like peptidase (C01 family) | | 著者 | Jilkova, A, Rezacova, P, Pachl, P, Fanfrlik, J, Rubesova, P, Guetschow, M, Mares, M. | | 登録日 | 2020-04-01 | | 公開日 | 2020-12-16 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | | 主引用文献 | Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni : Structural and Mechanistic Insights into Chemotype Reactivity.
Acs Infect Dis., 7, 2021
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5MQ0
 | | Structure of a spliceosome remodeled for exon ligation | | 分子名称: | 3'-EXON OF UBC4 PRE-MRNA, BOUND BY PRP22 HELICASE, 5'-EXON OF UBC4 PRE-MRNA, ... | | 著者 | Fica, S.M, Oubridge, C, Galej, W.P, Wilkinson, M.E, Newman, A.J, Bai, X.-C, Nagai, K. | | 登録日 | 2016-12-19 | | 公開日 | 2017-01-18 | | 最終更新日 | 2020-10-07 | | 実験手法 | ELECTRON MICROSCOPY (4.17 Å) | | 主引用文献 | Structure of a spliceosome remodelled for exon ligation.
Nature, 542, 2017
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7NEE
 | | Inhibitor Complex with Thrombin Activatable Fibrinolysis inhibitor (TAFIa) | | 分子名称: | (1R,3S)-3-(4-ammoniobutyl)-1-benzyl-1,4-azaphosphinan-1-ium-3-carboxylate 4,4-dioxide, Carboxypeptidase B2, ZINC ION | | 著者 | Brown, D.G, Schaffner, A.P, Gloanec, P, Raimbaud, E, Vuillard, L.M. | | 登録日 | 2021-02-03 | | 公開日 | 2021-04-07 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Phosphinanes and Azaphosphinanes as Potent and Selective Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor (TAFIa).
J.Med.Chem., 64, 2021
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7PUS
 | | ERK5 in complex with Pyrrole Carboxamide scaffold | | 分子名称: | 4-[3,6-bis(chloranyl)-2-fluoranyl-phenyl]carbonyl-~{N}-(1-methylpyrazol-4-yl)-1~{H}-pyrrole-2-carboxamide, Mitogen-activated protein kinase 7 | | 著者 | Tucker, J.A, Martin, M.P, Endicott, J.A, Noble, M.E.N. | | 登録日 | 2021-09-30 | | 公開日 | 2022-05-11 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor.
J.Med.Chem., 65, 2022
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7NEU
 | | Inhibitor Complex with Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) | | 分子名称: | (1R,3S)-3-(4-ammoniobutyl)-1-(4-fluoro-2-(1-methyl-1H-imidazol-5-yl)benzyl)-1,4-azaphosphinan-1-ium-3-carboxylate 4,4-dioxide, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Brown, D.G, Schaffner, A.P, Vuillard, L.M, Gloanec, P, Raimbauld, E. | | 登録日 | 2021-02-04 | | 公開日 | 2021-04-07 | | 最終更新日 | 2021-04-21 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Phosphinanes and Azaphosphinanes as Potent and Selective Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor (TAFIa).
J.Med.Chem., 64, 2021
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6PX0
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8JTJ
 | | Cryo-EM structure of GeoCas9-sgRNA-dsDNA ternary complex | | 分子名称: | CRISPR-associated endonuclease Cas9, DNA (29-MER), DNA (5'-D(P*GP*GP*GP*CP*GP*CP*GP*AP*A)-3'), ... | | 著者 | Shen, P.P, Liu, B.B, Li, X, Zhang, L.L, Chen, C.-C, Guo, R.-T. | | 登録日 | 2023-06-21 | | 公開日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | Cryo-EM structure of GeoCas9-sgRNA-DNA ternary complex
To Be Published
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5MZK
 | | Pseudomonas fluorescens kynurenine 3-monooxygenase (KMO) in complex with 3-[5-chloro-6-(cyclobutylmethoxy)-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid | | 分子名称: | 3-[5-chloro-6-(cyclobutylmethoxy)-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Rowland, P. | | 登録日 | 2017-01-31 | | 公開日 | 2017-04-19 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.
J. Med. Chem., 60, 2017
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5YI3
 | | Structure of Lactococcus lactis ZitR, C30S mutant in complex with DNA | | 分子名称: | DNA (5'-D(*TP*GP*TP*TP*AP*AP*CP*TP*AP*GP*TP*TP*AP*AP*CP*A)-3'), ZINC ION, Zinc transport transcriptional regulator | | 著者 | Song, Y, Liu, H, Zhu, R, Yi, C, Chen, P. | | 登録日 | 2017-10-01 | | 公開日 | 2017-12-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation.
Proc.Natl.Acad.Sci.USA, 114, 2017
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8S8G
 | | Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-2.1) | | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein L41-A, 40S ribosomal protein S12, ... | | 著者 | Villamayor-Belinchon, L, Sharma, P, Llacer, J.L, Hussain, T. | | 登録日 | 2024-03-06 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural basis of AUC codon discrimination during translation initiation in yeast.
Nucleic Acids Res., 2024
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8RW1
 | | Structure of a yeast 48S-AUC preinitiation complex in closed conformation | | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein L41-A, 40S ribosomal protein S12, ... | | 著者 | Villamayor-Belinchon, L, Sharma, P, Llacer, J.L, Hussain, T. | | 登録日 | 2024-02-02 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | | 主引用文献 | Structural basis of AUC codon discrimination during translation initiation in yeast.
Nucleic Acids Res., 2024
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7PKK
 | | LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria | | 分子名称: | (2R,4R)-1-cyclopropylcarbonyl-4-[[(2S,4S)-4-fluoranylpyrrolidin-2-yl]carbonylamino]-N-[[4-[2-[4-(morpholin-4-ylmethyl)phenyl]ethynyl]phenyl]methyl]pyrrolidine-2-carboxamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION | | 著者 | Ryan, M.D, Pallin, T.D, Lamers, M.B.A.C, Leonard, P.M. | | 登録日 | 2021-08-25 | | 公開日 | 2022-09-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria
To Be Published
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8S8E
 | | Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-3.1) | | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein L41-A, 40S ribosomal protein S12, ... | | 著者 | Villamayor-Belinchon, L, Sharma, P, Llacer, J.L, Hussain, T. | | 登録日 | 2024-03-06 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (3.85 Å) | | 主引用文献 | Structural basis of AUC codon discrimination during translation initiation in yeast.
Nucleic Acids Res., 2024
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8S8J
 | | Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-eIF5) | | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein L41-A, 40S ribosomal protein S12, ... | | 著者 | Villamayor-Belinchon, L, Sharma, P, Llacer, J.L, Hussain, T. | | 登録日 | 2024-03-06 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | Structural basis of AUC codon discrimination during translation initiation in yeast.
Nucleic Acids Res., 2024
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8S8D
 | | Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-2) | | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein L41-A, 40S ribosomal protein S12, ... | | 著者 | Villamayor-Belinchon, L, Sharma, P, Llacer, J.L, Hussain, T. | | 登録日 | 2024-03-06 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | | 主引用文献 | Structural basis of AUC codon discrimination during translation initiation in yeast.
Nucleic Acids Res., 2024
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8S8H
 | | Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-2.2) | | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein L41-A, 40S ribosomal protein S12, ... | | 著者 | Villamayor-Belinchon, L, Sharma, P, Llacer, J.L, Hussain, T. | | 登録日 | 2024-03-06 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural basis of AUC codon discrimination during translation initiation in yeast.
Nucleic Acids Res., 2024
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7PK8
 | | LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria | | 分子名称: | (2S,4S)-4-fluoranyl-N-[(3R,5R)-5-[[[4-[2-(4-methylphenyl)ethynyl]phenyl]carbonylamino]methyl]-1-(2-methylpropanoyl)pyrrolidin-3-yl]pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ... | | 著者 | Ryan, M.D, Pallin, T.D, Lamers, M.B.A.C, Leonard, P.M. | | 登録日 | 2021-08-25 | | 公開日 | 2022-09-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria
To Be Published
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7PHN
 | | LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria | | 分子名称: | (2~{R},4~{R})-4-[[(2~{S},4~{S})-4-fluoranylpyrrolidin-2-yl]carbonylamino]-1-(2-methylpropanoyl)-~{N}-[[4-(2-phenylethynyl)phenyl]methyl]pyrrolidine-2-carboxamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION | | 著者 | Ryan, M.D, Pallin, T.D, Lamers, M.B.A.C, Leonard, P.M. | | 登録日 | 2021-08-17 | | 公開日 | 2022-09-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria
To Be Published
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7PJG
 | | LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria | | 分子名称: | (2R,4R)-N-[[4-(4-cyclopropylbuta-1,3-diynyl)phenyl]methyl]-1-(2-methylpropanoyl)-4-[[(2S,4R)-4-oxidanylpyrrolidin-2-yl]carbonylamino]pyrrolidine-2-carboxamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION | | 著者 | Ryan, M.D, Pallin, T.D, Lamers, M.B.A.C, Leonard, P.M. | | 登録日 | 2021-08-24 | | 公開日 | 2022-09-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria
To Be Published
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5NAH
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